DrBeen#30 Antinuclear Antibodies as Predictors of Long COVID

In this discussion we will go over a Canadian study about the persistence of the ANA and inflammatory mediators that predict long COVID symptoms. There's good news as well that these mediators and antibodies reduce over time.

URL list from Thursday, Oct. 29 2022

Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms | European Respiratory Society
https://erj.ersjournals.com/content/early/2022/08/04/13993003.00970-2022

Anti-SSB/La is one of the antineutrophil autoantibodies responsible for neutropenia and functional impairment of polymorphonuclear neutrophils in patients with systemic lupus erythematosus - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808654/

U1 spliceosomal RNA - Wikipedia
https://en.wikipedia.org/wiki/U1_spliceosomal_RNA

Antinuclear antibodies: cause of disease or caused by disease? | Rheumatology | Oxford Academic
https://academic.oup.com/rheumatology/article/39/6/581/1783869

Histones - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/histones

Antinuclear Antibodies (ANA)
https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antinuclear-Antibodies-ANA

Linker DNA - Wikipedia
https://en.wikipedia.org/wiki/Linker_DNA

Biochemistry, Antinuclear Antibodies (ANA) - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK537071/

Rheumatic Diseases - Mayo Clinic Health System
https://www.mayoclinichealthsystem.org/locations/mankato/services-and-treatments/rheumatology/rheumatic-diseases

Antinuclear antibody - Wikipedia
https://en.wikipedia.org/wiki/Antinuclear_antibody

Patient education: Antinuclear antibodies (ANA) (Beyond the Basics) - UpToDate
https://www.uptodate.com/contents/antinuclear-antibodies-ana-beyond-the-basics/print

Nuclear localizing anti-DNA antibodies enter cells via caveoli and modulate expression of caveolin and p53 - PubMed
https://pubmed.ncbi.nlm.nih.gov/15829407/

In vivo cell penetration and intracellular transport of anti-Sm and anti-La autoantibodies | International Immunology | Oxford Academic
https://academic.oup.com/intimm/article/12/4/415/693650

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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.