Studies show that neurons are metabolically protected when low dose Methylene Blue is administered systemically. Methylene Blue promotes energy metabolism and neuronal survival. A similar protective effect is observed with near infrared light. Let's review.

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References
URL list from Thursday, Nov. 10 2022

Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light
https://www.frontiersin.org/articles/10.3389/fncel.2015.00179/full

Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy | Molecular Medicine | Full Text
https://molmed.biomedcentral.com/articles/10.2119/molmed.2015.00038

Effect of Methylene Blue on White Matter Injury after Ischemic Stroke - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872771/

Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352658/

Frontiers | Methylene Blue Reduces Neuronal Apoptosis and Improves Blood-Brain Barrier Integrity After Traumatic Brain Injury
https://www.frontiersin.org/articles/10.3389/fneur.2019.01133/full

Addressing Personal Protective Equipment (PPE) Decontamination: Methylene Blue and Light Inactivates SARS-CoV-2 on N95 Respirators and Masks with Maintenance of Integrity and Fit | medRxiv
https://www.medrxiv.org/content/10.1101/2020.12.11.20236919v2.full

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00197-z

Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694374/

Shining light on the head: Photobiomodulation for brain disorders - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/

Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia | Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.ahajournals.org/doi/10.1161/ATVBAHA.108.181628

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)
https://www.spandidos-publications.com/10.3892/ijmm.2019.4188#:~:text=The%20sites%20of%20ROS%20production,peroxide%20(48%2C49).

Frontiers | Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
https://www.frontiersin.org/articles/10.3389/fphys.2021.627837/full#:~:text=Mitochondrial%20reactive%20oxygen%20species%20are,et%20al.%2C%202013).

Mitochondria—Fundamental to Life and Health - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684129/

After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning - PubMed
https://pubmed.ncbi.nlm.nih.gov/29151273/

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