Dan McCollum MD
Assistant Program Residency Director at Georgia Regents University
Augusta, Georgia
Academic Medical center, Level 1 Trauma Center: census >90,000/yr
“If someone is doing an effective therapy out of the back of a truck successfully, and you can’t make it work in your hospital, then you suck and should feel bad.”
Case: 38 y/o female multi-drug OD on (possibly):
Montelukast 10 mg (Singulair) – leukotriene receptor antagonist. mild tox profile (3698 pediatric ingestions from Texas Poison Control: 95% asymptomatic)Promethazine 25 mg (Phenergan) – Anticholinergic (56% tachycardia, 42% delirium, 2% mechanical ventilation, 1% hypotension)Cyproheptadine 4 mg – Anticholinergic; mild tox profile (892% of OD in one case series had no or mild symptoms)Clonazepam 1 mg (Klonipin) – Common: respiratory depression and hypotension; Rare: heart block/dysrythmiaAmitriptyline 25 mg – TCA – Hypotension. QRS widening with R wave in AVRTreatment:antidote = sodium bicarbonatecrystalloid for hypotensionPressors for refractory hypotensionAmlodipine 5 mg – Calcium Channel Blocker – Common: Bradycardia, hypotension, heart block; Rare: apnea, pulmonary edema, ARDS, coma, Lactica acidosis, hypoerglycemia, bowel infarctionTreatment:IVFHigh Dose Calcium (inotrope)Pressors – IsoproterenolGlucagonAtropineHigh Dose Insulin – 1-10 unit/kg/hr infusion (consider simultaneous glucose infusion)02:00-17:00 Estimated time of ingestion: (2-15 hours PTA).19:00 Presentation to ED19:30 BP 55/33; sats 93% on 60% FiO219:41 PEA ARREST #1Epinephrine, Atropine, Sodium Bicarbonate, Calcium Gluconate, D50Narcan > No response19:54 Bradycardia with pulse20:10 Bicarbonate gtt20:15 Epinephrine gtt20:18 High Dose Insulin bolus, then gtt20:31 TC pacing20:40 Norepi gtt, Charcoal20:46 CXR = pulmonary edema21:07 Bivent initiation21:14 Intralipid bolus21:16 Glucagon21:21 43/29 with sats 69% and pulse 7021:31 pRBC transfusion initiatedTotal Meds used in resuscitation:
Calcium Gluconate: 21 AmpsSodium Bicarbonate: 19 AmsEpinephrine: 9.5 mg + dripsInsulin: ~150 unitsComplications during hospitalization (but the patient is alive!):
AF with RVRDVTipsilateral limb ischemia > Necrotizing fasciitis > AKAPleural Effusion > chest tubeBowel perforation (due to ischemia) > laparotomyTrach/PEGAbdominal Wall Abscess > I&DRUSH exam early for undifferentiated shockRestrictive lung strategy to avoid ARDSMulti-agent OD: contact Poison Control – they can actually help! 1-800-411-8080ECMO is a bridge to metabolism/recovery.“If someone is doing an effective therapy out of the back of a truck successfully, and you can’t make it work in your hospital, then you suck and should feel bad.” – Dan
*and special thanks to Dan McCollum for creating and sharing the Napoleon Dynomite memes.