Trial Publication on the JAMA

BaSICS Trial (Fluid Rate)

BaSICS Trial (Fluid Choice)

Zampieri et al.

~11,000 patient trial

90 Day Mortality was the primary

The mean (SD) volume infused as boluses on day 1 was 1162 mL (916 mL) for slower infusion vs 1252 mL (1009 mL) for control infusion rate.

did not randomize fluid received before ICU

 

Take Home Message

There was no statistically significant difference between the 2 groups with respect to fluid choice (NS vs. Plyte 148) or infusion rate (333 mL/h vs. 999 mL/h). Patients were also randomized to receive balanced solution or 0.9% saline using a factorial design.

Now on to the Wee...