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This detailed podcast episode delves into the findings of a study on Chronic Fatigue Syndrome (CFS) using functional MRI and immune system analysis. The speaker explains the technology behind functional MRI and what it revealed about brain activity, specifically in the parietal temporal junction, which showed hypoactivity in CFS patients. The discussion extends to immune abnormalities, highlighting immune cell exhaustion, and hypothesizing links to persistent infections. The episode emphasizes the need for interdisciplinary, evidence-based approaches to treating these 'invisible' illnesses and calls for more integrated, patient-centric research. Other discussed topics include the limitations of current medical specialization and the need for generalist knowledge, the role of gut microbiome, and potential lessons from oncology on immune checkpoints.

00:00 Introduction to Functional MRI
01:48 Understanding Functional MRI Findings
04:08 Immune System Insights
04:54 Cancer Research and Immune Exhaustion
09:01 Genetic Susceptibility and Long COVID
10:33 Holistic Approach to Medicine
13:34 Challenges in Treating CFS and Fibromyalgia
15:38 Future Directions in Research
22:40 Gut Microbiome and Immune Response
25:41 Neurodivergence and Immune System
29:25 Conclusion and Final Thoughts

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When I started this podcast—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That’s why I created this space: to offer education, validation, and hope. If you’ve been told fibromyalgia “isn’t real” or that it’s “all in your head,” know this—I see you. I believe you. You’re not alone. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you’ll find trusted, evidence-based insights here, drawn from my 28+ years as an MD.

Please remember to talk with your doctor about your symptoms and care. This content doesn’t replace personal medical advice.*

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