Male and Female Reproductive Pharmacology Suffixes

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I hit some of the high points in reproductive male and female pharmacology regarding prefixes, suffixes, and infixes. If you want a more detailed review, you can check out the audiobook: https://www.audible.com/pd/Memorizing-Pharmacology-Audiobook/B09JVBHRXK?source_code=AUDFPWS0223189MWT-BK-ACX0-281667&ref=acx_bty_BK_ACX0_281667_rh_us

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Auto Generated Transcript:

Welcome to the Memorizing Pharmacology podcast. I'm Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Let's get started with the show.

Okay, I wanted to go over male and female reproductive pharmacology suffixes. I'm Tony Guerra, your host. Just wanted to make sure that I say suffixes, but we're going to see some things that are in between which are technically infixes versus prefixes and so forth. So let's just take a look here at what we're kind of dealing with.

So testosterone, a lot of people think the 'one' is what makes it a certain type of drug but really we're talking about these male hormones. We're really talking about the 'ster' for steroid and you'll notice that 'sterone' is also in progesterone but the male hormone is testosterone brand AndroGel which is a controlled substance. It can be, I guess addicting is the way to put it, and it's an anabolic steroid something that is going to build up muscle versus remember catabolism, anabolism. Catabolism breaks down or crushes, anabolism builds up.

Estrogen, the 'estr' is uh was Premarin and that came from pregnant mare's urine so the 'prma' and 'in' for prma Rin and then progesterone the progestin this is the other half of it. So when we look at these individually you know I always think of the Four A's with testosterone and we got this really brave guy here and this really anxious guy here but there is that addictive potential it is C3 it can cause anxiety okay can cause acne so kind of think about uh you know really what is it like to be a high school guy is what I was thinking is like well you've got to deal with um potential for you know addiction with uh you know whether it's video games to other stuff you've got anxiety being you know accepted by your peers you've got acne and then aggression as you kind of go through puberty and all those things so testosterone that's kind of testosterone in a nutshell.

We then go to kind of understanding okay well let me identify which one is the progestin and which one is the estrogen and the way again to do that is the 'gest' g-e-s-t is the progestin and the 'estr' is the estrogen so this is trisprintech which is a um one of our combined birth control pills slight risk of blood clots smokers really should just be using progestin only there can be significant cardiac effects and how long do you have to wait as a smoker well really you should be waiting almost a whole year before if you stop smoking to go on an estrogen type to avoid that increased cancer risk.

In terms of cancer risk, you're going to usually see breast and cervical go up endometrial ovarian and colorectal go down but the pictures here the breathe and the heart are specifically for that smoking to use progestin only versus a combination pill when we talk about alpha blockers and five Alpha reductase Inhibitors we're really talking about a kind of a one-two punch for BPH or benign prostatic hyperplasia where the immediate relief comes from tamsulosin or Flomax okay so this is an alpha one blocker.

The problem is it doesn't actually fix the problem it just allows you know easier urine flow so you're going to see some of those adverse effects which you'll see with any Alpha blocker first dose phenomenon or syncope where somebody gets kind of a fainting hypertension reflex tachycardia though these things are much less likely than their than tamsulosin's cousins like doxazosin and terazosin or terazosin however you pronounce however you want to pronounce it and those guys but still possibility because Alpha One really pregnant women foreign.

And you're going to see that this is kind of the first thing you give and you'll give them together but this is kind of providing relief during the months that it takes for The Other Drug to work so it works quickly it's going to eventually be removed you're not going to give both medications for the long term so what we're trying to do long term is we're trying to shrink the prostate and do testosteride or finasteride those are the two drugs that do it avidart is dutasteride finasteride.

Finasteride is one of those weird drugs that has two brand names for two different indications so the Propecia side of finasteride a much smaller dose is going to help with somebody's male pattern baldness or hair growth and then the Proscar is prostate care so caring for the prostate that has BPH. So the 5-alpha reductase inhibitor, it's really stopping DHT that's what it's doing. You've got to worry about ED, decreased ejaculate and libido, gynecomastia and hair growth and you can see that somebody who's dribbling or having this issue with BPH might say you know what those adverse effects are not worth it to me so compliance may be an issue. Contradicting pregnant women, you don't want them to handle it. You would have to double glove if you did and then it takes up to six months to work.

So again, Tamsulosin first and just think of the alpha as the first um you know Alpha One as the first and then the five Alpha as the one that comes a lot later and because five months is close to six months you can think of five Alphas about how long it's going to take for this to hit its full effect. Sildenafil versus Tadalafil so these are for rectal dysfunction, the stem is a fill afil and they increase nitric oxide to help with the erection so phosphodiesterase five Inhibitors now priapism or priapism however you decide to pronounce it is a four hour erection and an emergency.

There are some treatments for it I'm not going to go over them but the key is that um if it's a four hour erection you really don't want to um you need to go to the hospital. It's contraindicated with nitroglycerin and that's because it would create a tremendous drop in blood pressure and this is the big difference like well why would I take Viagra versus Tadalafil. And when Viagra first came out it was Sildenafil okay but once Tadalafil came out you saw the bathtubs or the two bathtub commercials and the reason for that is that it lasts up to 36 hours.

So Sildenafil if you think the time is right and the time is wrong well you're out of luck but Tadalafil provides more forgiveness for the entire weekend and then that was the kind of big big difference between the two. Okay uh just a little bit about our story with the triplet pregnancy for those of you that don't know right now I have three 11 year old girls they'll be turning 12 in July but there are a couple of drugs that kind of came along uh on the ride with us and that allowed them to be uh how they are now.

But uh Metformin uh was the drug that we use not Clomiphene so Clomiphene is a drug that is often used for those that can't um conceive and Metformin just did the trick. And so there's only a one in ten thousand chance of having triplets uh it's very unlikely so that was great but what happened was we had the chance and we did not take it to abort one of the children um to increase the chances of the other two and we turned that down and that was what we thought was oh my God we've killed them all because they almost came out at 19 weeks.

One of the girls just kind of decided and she's is the alpha she's the one that's just like she's already moved to you know another room in the house you know basically uh you know on her way out at 11. But uh Magnesium what was needed to stop the contractions uh she my wife went mag toxic and Nifedipine, the calcium channel blocker, dihydropyridine suppresses contractions uh long enough for them to start getting Betamethasone which is that steroid injection that helps with their lungs.

And they were delivered at 27 weeks in three days so the magic number is 28 weeks we got almost there uh it was actually I think time for almost another shot coming up and unfortunately they didn't get it, that would have made it alot easier for them but uh you know uh just uh really really lucky and um you know this was our first, second and last and I have a whole blog at ankenytriplets.com. But just I just want to show you, I think I talk too much about the words and don't show you what the impact is but this is what happens when you when the medications go right and you discover these things and you can have someone that's as tiny as they are uh survive and thrive. So this is Brielle um, we thought she was praying but maybe she was just kind of relaxing and just kind of putting the you know the hands to the side.

Our entrepreneurial one uh this is Tegan and she's got her 20 bill right there but we're just trying to show how small they really were. So if you look at your you know billfold and take out a dollar, you can see they're just an inch or two bigger than the dollar bill or your iPhone really um. This is if you just want some perspective, this is my index finger and um this is Rhian who's wrapping her fingers around my finger so just tiny tiny and you can see just how how um thin that skin is as they're in the giraffe okay.

And they're they have their uh sun, I call them sunglasses on but they have their little visor on there because they're trying to avoid chronic Terrace and they're under the UV light. And then I think this picture really shows as I'm taking the temperature under the arm there just how tiny uh they were and how fragile they were and just uh what a real miracle it was. So just uh thankful for all the medications and how it all worked out.

Again, this information is provided for informational purposes only, not intended to provide or should not be relied upon for medical or any other advice. I urge watchers, listeners, and readers to consult with a medical professional with any medical condition. Again if you need me, Tony the pharmacist at gmail.com.

Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes, cheat sheets, and more at memorizingfarm.com. Again, you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Thanks again for listening.

Like to learn more?

Find my book here: https://geni.us/iA22iZ

or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

Here is the Link to my Pharmacy Residency Courses: residency.teachable.com