Thinking About Ob/Gyn

Episode 11.8 MTHFR, Bed Rest, and More!


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We take on four stubborn myths in modern obstetrics and follow the evidence instead of the vibes, from thrombophilia testing to bed rest to seizure prophylaxis. We also spotlight a patient-empowering insulin strategy that may improve gestational diabetes outcomes faster than usual care. 
• distinguishing recurrent pregnancy loss evaluation from venous thromboembolism testing 
• focusing thrombophilia workups on antiphospholipid antibody syndrome when criteria are met 
• explaining why MTHFR variants and PAI-1 polymorphisms do not belong in routine panels 
• unpacking how social media and narrative fallacies keep low-value tests alive 
• reviewing the AWARE trial and why activity restriction lacks benefit and carries harms 
• clarifying reasonable pregnancy activity modifications versus false labor prevention claims 
• assessing late preterm antenatal corticosteroids for twins and the hypoglycemia signal 
• discussing inertia of practice and why weak evidence becomes hard to undo 
• breaking down patient-led insulin titration for gestational diabetes and why it may reduce macrosomia 
• evaluating laboring down and long-term pelvic floor outcomes plus statistical pitfalls 
• answering a listener question on Keppra alternatives to magnesium for preeclampsia seizures 
Be sure to check out thinking about obgyn.com for more information, and be sure to follow us on Instagram.

0:00 Welcome And What We’re Reviewing

0:28 Thrombophilia Testing After Miscarriage

3:51 What Belongs In A VTE Panel

5:55 MTHFR And PAI1 Myth Busting

13:36 Activity Restriction And The AWARE Trial

23:27 Practical Counseling Without False Promises

27:08 Late Preterm Steroids For Twins

32:53 Patient-Led Insulin Titration In GDM

38:38 Laboring Down And Pelvic Floor Outcomes

47:51 Keppra Versus Magnesium For Preeclampsia

1:00:25 Wrap Up And Where To Follow


Follow us on Instagram @thinkingaboutobgyn.

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Thinking About Ob/GynBy Antonia Roberts and Howard Herrell

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