Decades before Michelangelo climbed up on the nearly 70 feet of scaffolding to adorn the ceiling of the Sistine Chapel, a veritable "All-Star Team" of late-15th- century artists had already decorated its walls. Artists such as Sandro Botticelli, Domenico Ghirlandaio, Pietro Perugino, and Luca Signorelli were sent to Rome by Lorenzo "il Magnifico" de' Medici to pay homage to the original patron and namesake of the chapel – Pope Sixtus IV. This episode will examine the pre-history of the Sistine Chapel and the early Renaissance frescoes that had already transformed the chapel into an extraordinary decorative complex.