This episode examines the extraordinary early Renaissance fresco cycle in the family chapel of Giovanni Tornabuoni, who was the uncle of Lorenzo the Magnificent de' Medici. It was while Ghirlandaio was working on these frescoes in Santa Maria Novella in the 1480s that a 13-year-old apprentice named Michelangelo Buonarroti entered his workshop, who may have left his mark in the paintings.