When Leonardo began painting the portrait of Lisa Gherardini, wife of the wealthy cloth merchant Francesco del Giocondo, in 1503, little did he know just how much employment he would generate for future art historians. From theories concerning her enigmatic smile, to the painting being a self-portrait of Leonardo in drag, to her possibly being pregnant, just about everything that could possibly have been written about the Mona Lisa seems to have been written about her. In addition to analyzing the formal aspects of the painting, this episode also examines just why the painting is so famous.