During the Sack of Rome in 1527, thousands of citizens were killed or raped. The city's treasures were pillaged. Beyond the trauma and loss, the sack also crippled the Italian Renaissance for good.

When Hurricane Katrina hit New Orleans in 2005, over 1500 people died and thousands lost everything they had. A huge percentage of the displaced population never returned. Those who stayed were forever changed. Many locals mark time in NOLA as life "before Katrina" and life after.

Hosts Tiffany Parks (in Rome) and Katy Sewall (in New Orleans) explore how cities are forever altered by the natural and man-made disasters that strike.

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