Brandon D. Ayres, MD, continues this series exploring the best practices in keratoconus management with the discussion of the recent FDA approval of Epioxa, an advancement in corneal cross-linking for the treatment of keratoconus. Kenneth Beckman, MD, explains what excites him about Epioxa and how it can improve patient comfort and minimize recovery time. The two surgeons also review the role of supplemental oxygen during the procedure and review the Phase 3 pivotal trial data behind Epioxa.