In this quick literature update we review the new recommendations from the CDC for the treatment of gonococcal infections which include:

• Higher dose ceftriaxone (500 mg IM) or 1 gm IM if ≥150 kg patient
• No routine azithromycin
• Preference for doxycycline for co-treatment of presumed chlamydial infection

Show notes and references: FOAMcast.org

Thanks for listening! Lauren Westafer and Jeremy Faust

For years studies have questioned whether pulse oximeters perform as well in non-White patients as in White patients. This is particularly important now as disposition decisions in patients with COVID-19 are often made based on pulse oximetry readings.

We discussed an article by Sjoding et al in NEJM 

Show notes at FOAMcast.org

Thanks for listening! Lauren Westafer and Jeremy Faust

Despite multiple Phase II/III vaccine trials of >30,000 participants, pregnant patients or those who are lactating have been largely excluded. In this podcast, we cover what we know (and what we don't know thus far).

The Pfizer BNT162b2 trial data submitted for FDA Emergency Use Authorization does include information on a minuscule number of patients who were immunized and became pregnant.

The Society for Maternal and Fetal Medicine has released statements on vaccines in SARS-CoV-2.

In the United Kingdom, Public Health England has released guidance for their population on vaccination in pregnancy and breastfeeding which are rooted in the lack of data.

Shownotes: FOAMcast.org

Thanks for listening! Jeremy Faust and Lauren Westafer

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear*

Vaccines for SARS-CoV-2 have been in development for only a few months, but several have published early results from Phase III efficacy trials in press releases. In this episode, we review these vaccines and what we know about them, and what we know about  them

Show notes (references/graphics): FOAMcast.org

Thanks for listening, Lauren Westafer and Jeremy Faust

In this episode, we review cannabinoid hyperemesis syndrome and two recent randomized controlled trials on treatments

• Haloperidol - Ruberto et al  (Annals of Emergency Medicine, In Press)
• Capsaicin - Dean et al. Acad Emerg Med 2020.

Show notes (references, graphics) at FOAMcast.org

Thanks for listening!

Jeremy Faust and Lauren Westafer

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear*

Monoclonal antibodies have received significant attention over the past month and we previously podcasted on antibodies that target SARS-CoV-2. In this episode, we review several recent studies on a different "mab", tocilizumab,  which targets inflammation mediated by interleukin-6 that is overly ramped up. 

We review:

Stone et al  ( RCT)

Hermine et al (RCT)

Salvarani et al. (RCT)

STOP-COVID (observational)

Show notes (references/graphics): FOAMcast.org

Thanks for listening, Lauren Westafer and Jeremy Faust

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear*

Monoclonal antibodies have received significant attention over the past couple of weeks. In this episode, we review what we know, as of October 9, 2020, about monoclonal antibodies as a therapy for COVID-19. 

Show notes (references/graphics): FOAMcast.org

Thanks for listening, Lauren Westafer and Jeremy Faust

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear*

We review a retrospective evaluation of COVID-19 infections in employees after a protocol that increased the use of high flow nasal cannula (Westafer et al)

Show notes (references/graphics): FOAMcast.org

Thanks for listening, Lauren Westafer and Jeremy Faust

We spoonfeed you a new article on risk stratification of pulmonary embolism (with critical appraisal pearls!)

In this episode, we review a new trial by Barnes et al on antacids versus antacids with lidocaine for epigastric pain and dyspepsia

Show notes and references at FOAMcast.org

Thanks for listening,

Lauren Westafer and Jeremy Faust

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear*

We review a new meta-analysis from the WHO REACT group of steroids in critically ill patients with COVID-19 and 3 new randomized trials of steroids in COVID-19 published in JAMA on September 2:

• REMAP-CAP COVID-19 
• CoDEX
• CAPE Covid

Show notes (references/graphics): FOAMcast.org

Thanks for listening, Lauren Westafer and Jeremy Faust