A speck of bicycle paint and a speck nickel tie a suspect to the murder of a 9-year-old.

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While Earl Morris was vacationing in California, he learned that his wife had gone missing from their home in Arizona. The search for Ruby Morris involved dozens of investigators, scientists, and even the coast guard.

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A woman was reported missing, presumed dead. A clue inside the suspect's watchband and a popular television show helped solve the case.

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A 1986 case of sexual assault and serial murder marked the first time DNA was used as evidence in a court of law.

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Three seemingly unrelated deaths proved to be serial murders. The killer had been careful; he'd used poison which has no taste or odor. Fortunately for investigators, it also had a unique chemical signature.

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A twelve-year-old girl claimed she had been abducted and sexually assaulted. She recounted what happened in such a flat, unemotional voice that police found it difficult to believe her. Fibers on her clothing would prove she was telling the truth, and help police find her attacker.

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Two suspects living in the same apartment were linked to a murder by a gun and a pair of bloodstained boots - items that belonged to the one who claimed he'd never even met the victim. Investigators hoped the manufacturing code stamped on the six beer bottles would be distinctive enough to prove who was telling the truth, and who was a cold-blooded killer.

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It's usually easy to determine how a criminal entered a crime scene. But in this case, it was far from clear. It looked like the killer vanished into thin air... and perhaps he had.

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Twenty-four years after the death of a 15-year old in California, forensic scientists discover enough microscopic evidence to finally bring the killer to justice.

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The media dubbed him the "Last Call Killer" because he targeted men in gay bars who were obviously intoxicated. His MO involved dismembering the bodies and wrapping the parts in plastic bags, which he then carefully washed to remove all incriminating evidence. He eluded capture for almost ten years... and then new technology revealed fingerprints no one knew were there.

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