Four Generations of Winemaking Excellence Today, the Los Angeles River is paved and the vineyards have been replaced with businesses and homes. San Antonio Winery remains the oldest and largest producing winery in Los Angeles with over 100 years of winemaking, making it an essential component of the city’s cultural and historical landscape. Still sitting on its original location on Lamar Street, the winery is the last vestige of the rich winemaking tradition of greater Los Angeles. In the early 1960’s, Los Angeles’ Cultural Heritage Board designated the San Antonio Winery Cultural Monument Number 42. Take a listen to what they have to offer.