Freakonomics Radio

How do so many ineffective and even dangerous drugs make it to market? One reason is that clinical trials are often run on "dream patients" who aren't representative of a larger population. On the other hand, sometimes the only thing worse than being excluded from a drug trial is being included.

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We tend to think of medicine as a science, but for most of human history it has been scientific-ish at best. In the first episode of a three-part series, we look at the grotesque mistakes produced by centuries of trial-and-error, and ask whether the new era of evidence-based medicine is the solution.

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Standing in line represents a particularly sloppy — and frustrating — way for supply and demand to meet. Why haven't we found a better way to get what we want? Is it possible that we secretly enjoy waiting in line? And might it even be (gulp) good for us?

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The bad news: roughly 70 percent of Americans are financially illiterate. The good news: all the important stuff can fit on one index card. Here's how to become your own financial superhero.

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It's hard enough to save for a house, tuition, or retirement. So why are we willing to pay big fees for subpar investment returns? Enter the low-cost index fund. The revolution will not be monetized.

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The human foot is an evolutionary masterpiece, far more functional than we give it credit for. So why do we encase it in "a coffin" (as one foot scholar calls it) that stymies so much of its ability — and may create more problems than it solves?

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Good intentions are nice, but with so many resources poured into social programs, wouldn't it be even nicer to know what actually works?

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Over 40 percent of U.S. births are to unmarried mothers, and the numbers are especially high among the less-educated. Why? One argument is that the decline in good manufacturing jobs led to a decline in "marriageable" men. Surely the fracking boom reversed that trend, right?

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How a pain-in-the-neck girl from rural Virginia came to run the most powerful university in the world.

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Charles Koch, the mega-billionaire CEO of Koch Industries and half of the infamous political machine, sees himself as a classical liberal. So why do most Democrats hate him so much? In a rare series of interviews, he explains his political awakening, his management philosophy, and why he supports legislation that goes against his self-interest.

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