From First Principles

Hosted by Lester Nare and Krishna Choudhary, this story dives into Microsoft’s analog optical AI computer — a breakthrough published in Nature that runs on light instead of transistors. The system cracks two fundamental AI bottlenecks, achieving 100× energy efficiency compared to GPUs. Beyond cutting costs and power demand for data centers, the same architecture could reduce MRI scans from an hour to just five minutes, showing how fundamental physics can transform both tech and healthcare.

Summary

• Microsoft unveils an analog optical AI computer, published in Nature

• Why Moore’s Law slowdown and the von Neumann bottleneck strain AI computing

• AI’s energy demand projected to hit 20% of global electricity by 2030

• Analog design uses LEDs, filters, and CCDs instead of GPUs

• Solves matrix multiplication and nonlinearities directly in hardware

• Delivers 100× energy efficiency over GPUs

• Works for inference, not training — but that’s most AI usage

• Bonus: excels at combinatorial optimization like MRI reconstruction

• Medical impact: MRI scans reduced from 30–60 minutes to ~5 minutes

Show Notes

• Nature — Analog AI Research
• Microsoft Research Blog

Hosted by Lester Nare and Krishna Choudhary, this story explores a breakthrough from Northwestern University: a nickel-based catalyst that could transform plastic recycling. Instead of requiring costly sorting or producing low-value waste, this method selectively breaks down polypropylene while leaving polyethylene intact — even turning common contaminants like PVC into a benefit. The result is a scalable approach that could finally make large-scale plastic recycling practical.

Summary

• Plastic is cheap and convenient — but environmentally devastating

• Current recycling methods (mechanical, pyrolysis) are inefficient or polluting

• Breakthrough: nickel-based catalyst for hydrogenolysis

• Selectively targets polypropylene while ignoring polyethylene

• Works even in the presence of PVC, improving outcomes

• Achieved 99.5% polypropylene conversion in 20 minutes

• Industrial promise: chemical sorting replaces costly manual sorting

Show Notes

• Nature Chemistry — No-Sort Plastic Catalyst

Hosted by Lester Nare and Krishna Choudhary, this story examines a major international study published in PNAS suggesting human life expectancy may have plateaued for cohorts born after 1939. We trace the “longevity revolution” driven by vaccines, antibiotics, and sanitation, then unpack why new data indicates we may be hitting biological and societal limits.

Summary

• Headline: generations born after 1939 unlikely to reach 100

• Collaboration: Max Planck Institute, INED (France), UW–Madison

• How we measure life expectancy: period vs. cohort

• Six independent models + historical validation show a plateau

• Low-hanging fruit solved; remaining hurdles: cancer, neurodegeneration

• Policy ripple effects: pensions, retirement age, social security

• Equity concerns: impacts fall hardest on lower-income workers

Show Notes

• PNAS — Longevity Plateau Study

• The Independent — Coverage

Hosted by Lester Nare and Krishna Choudhary, this story unpacks the discovery of 3I/Atlas — the third confirmed interstellar object to pass through our solar system. Captured by Hubble, JWST, TESS, and ESA orbiters, Atlas is moving at 61 km/s and may be older than our Sun. We explore why its bizarre composition excites astronomers, how Mars orbiters and future missions will gather data, and what it means for understanding the diversity of planetary systems beyond our own.

Summary

• 3I Atlas confirmed as only the third interstellar object observed

• Discovered by the ATLAS program in Chile on July 1, 2025

• Speed: 61 km/s, ensuring it won’t remain in the solar system

• Unique CO₂-to-water ratio (8:1) unlike solar system comets

• What this reveals about its birth environment and possible age (~7B years)

• Why orbiters at Mars and ESA probes will be critical for further study

• Broader significance: sampling galactic diversity one visitor at a time

Show Notes

• Space.com — 3I Atlas Coverage

Hosted by Lester Nare and Krishna Choudhary, Episode 7 of From First Principles covers four stories at the frontier of science and technology. This week, we dive into new telescope data on the interstellar visitor 3i Atlas, explore a major longevity study that suggests life expectancy may have plateaued, unpack a breakthrough nickel catalyst that could enable no-sort plastic recycling, and look at Microsoft’s analog AI computer — a potential game-changer for energy efficiency and medical applications.

Summary

• Interstellar comet 3i Atlas imaged by Hubble, JWST, TESS, and ESA orbiters

• Longevity study shows human life expectancy may have plateaued post-1939 births

• Northwestern researchers develop a nickel catalyst for no-sort plastic recycling

• Microsoft unveils an analog optical AI computer with 100x GPU efficiency

Show Notes

• Space.com — 3I/Atlas Coverage
• PNAS — Longevity Plateau Study
• Nature Chemistry — No-Sort Plastic Catalyst
• Nature — Analog AI

Hosted by Lester Nare and Krishna Choudhary, this story spotlights an Oxford-led breakthrough: a CRISPR-engineered “superfood” for honeybees. By bioengineering yeast to produce essential sterols, lipids, and vitamins that typical feeds lack, researchers achieved dramatic improvements in colony health—reporting up to a 15× increase in viable pupae—offering a potential lifeline for pollinators and global food security.

Summary

• Why bees matter: ~1 in 3 bites of human food relies on pollinators

• Economic impact: hundreds of billions globally; tens of billions in the U.S.

• The problem: climate stress, habitat loss, and a critical nutritional gap

• The solution: CRISPR-edited yeast producing essential sterols for bee diets

• Results: up to 15× more viable pupae and sustained brood rearing

• Bonus: reduces resource competition between farmed and wild pollinators

If you want to watch the full episode 6, you can view it here:

⁠Full Episode

Show Notes

• BBC Coverage

• Nature Paper

Hosted by Lester Nare and Krishna Choudhary, this story explores how scientists in Korea are harnessing the overlooked property of electrons — their spin — to build ultra–low-power devices. By flipping the script and treating energy loss as a feature rather than a flaw, researchers are pushing the frontier of spintronics and opening new doors for AI, data, and computing efficiency.

Summary

• Politicians spin news, scientists spin electrons
• Korea’s breakthrough: turning spin loss into usable energy
• Spintronics explained: using both electron charge and spin
• Moore’s Law slowdown and the Von Neumann bottleneck
• Early success: giant magnetoresistance and Nobel-winning hard disks
• New approach: using dissipation as a functional component
• Why this could reshape computing and AI’s energy demands
• Commercial viability: compatible with existing chip infrastructure
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If you want to watch the full episode, you can view it here: Full Episode

Show Notes

• Phys.org Coverage
• Nature Communications Paper

Hosted by Lester Nare and Krishna Choudhary, this story explores a groundbreaking cancer therapy from Columbia Engineering that uses bacteria to smuggle viruses directly into tumors. The result? A synergistic “buddy cop” approach where pathogens team up against cancer, showing 100% survival in early mouse studies and pointing toward a new frontier in adaptive biotherapy.

Summary

• Marvel-style intro: viruses + bacteria as the ultimate team-up
• Columbia Engineering’s CAPSID therapy published in Nature Biomedical Engineering
• Trojan horse design: bacteria smuggle viruses into tumors
• Why current treatments (chemo, radiation, CAR-T) struggle with specificity
• Experimental results in mice: tumors eliminated in both injected and distant sites
• Adaptive, modular potential for future cancer therapies
• 
  

If you want to watch the full episode, you can view it here: Full Episode

Show Notes

• Columbia Engineering Coverage
• Nature Biomedical Engineering Paper

Hosted by Lester Nare and Krishna Choudhary, this story dives into the groundbreaking discovery of a new type of supernova — a cosmic explosion so rare it occurs only ~300,000 times per year across the entire observable universe. We explore what makes this event unique, how it confirms long-standing models of stellar evolution, and why global collaboration was key to capturing it.

Summary

• Astronomers observe a never-before-seen type of supernova in 2021
• The event confirms the “onion skin” model of stellar interiors
• Supernovas as crucibles for elements beyond iron — gold, zinc, uranium
• Global telescopes team up to monitor the rare explosion for 120 days
• Why timing, technology, and collaboration matter for catching cosmic phenomena

If you want to watch the full episode 6, you can view it here:

Full Episode

Show Notes

• CNN Coverage
• Nature Paper

Hosted by Lester Nare and Krishna Choudhary, Episode 6 of From First Principles covers four groundbreaking stories in science—from rare cosmic explosions to synthetic biology breakthroughs that could save our food supply. This week, we dive into a never-before-seen type of supernova, explore a surprising alliance of viruses and bacteria against cancer, unpack how scientists are turning electron spin into power, and highlight Oxford’s CRISPR-based superfood for honeybees.

Summary

• A naked supernova reveals the inner layers of a dying star
• Viruses and bacteria team up to fight cancer with Trojan-horse biology
• Harnessing electron spin for ultra-efficient future tech
• Scientists engineer bee superfood to save pollinators and agriculture

Show Notes

• CNN — New Supernova Discovery
• Nature — Virus+Bacteria Therapy
• Phys.org — Spintronics Study
• BBC — Bee Superfood