Obesity and Cancer- Your Fault or Your Genetics
intro conversation
Does genetics impact you getting obese.
Maybe;
Genetics minor role
Your choices and circumstances can increase or decrease your genetic risk
This means we can somewhat control it
A few hundred years ago we werent eating and very active to survive
hence why we have fat to store
Society allows easy access- and we eat excess
Good news is that you have the control this
Anyone can lose weight
Calories in vs out
Decreased metabolism, diabetes, complicate
But unhealthy life style caused it
Changing to a healthy one early enough reverses it and many others.
Genetics and obesity FTO
Cant deny environments part on making us obese, but how much does genetics matter?
“Runs in the family” - habits, not genetics
Italian pasta sedentary family- kids become?
Our genes didn’t suddenly change 100 years ago.(obesity)
however 100-ish genetic markers linked to obesity.
all of them together account for less than 3% difference in BMI between people
. The “fat gene” (called FTO, “FaT mass and Obesity associated’’) most linked
less than 1 percent difference between people- 0.34 percent.
Do you have FTO?
Who cares- results in a few hundred extra calories per year
In other words, no; those genes don’t make you look fat.
FTO gene has appears weaker among physically active,
may be abolished in those eating healthier diets.
FTO only appears to affect certian high sat/tran fats and sugar
Thos active and healthy eating, no increased weight gain risk even with fto from both parents
FTO gene status does not appear to affect your ability to lose weight.
We were designed for food to be addicting
Obesity does usually become lack of willpower
Eat right, workout right, live well)drink smoke)
Our environment makes us use self control for food
Id love to eat a bunch of junk too, some of it is delicious!- moderate
We are designed to eat everything, and move to survive- not required anymore
its why we crave sugar and fat- fast and high cal
Since food wasnt always available, those that could eat the most survived the longest.,
We no longer need to be active to be alive, so we have to do it voluntarily a lot- exercise
Cancer and genetics
Cancer= mutations, then uncontrolled growth
External- tobacco, alcohol, standing in radioactive sludge, south park microwave etc
Internal- “random cellular changes
Inherited mutations-
Different; in the dna of every cell
Genetics affect cancer, but so does environment
Inherited genetic mutations plays role in 5 to 10 percent of all cancers
Slightly more with hormonal cancers in generl
Colon CA- has been increasing 1% to 3% annually- not solely genetic
Our environment will activate those susceptible to cancer
Cancer growers- like kidney stone growers
.Genetic testing for cancers-
can, but may not want to, depends.
Suggested if
several close relatives have had it,
if youve had it or another cancer before,
Just want to be proactive
Have a physical trait suggesting CA- Café-au-lait spots
Neurofibromatosis-
Genetic, changes nerve growth, causes nerve tumors
10% to 25% have café-au-lait spots; NF
is suspected when a person has 6 or more
Cancer and Enviroment-
“Everything causes cancer now”
Cleaners, tobacco, alcohol, standing in radioactive goo, cooking with foil
Cancer percentage has increased
Especially younger adults, 20-50yrs
heavily correlated with youth obesity
Excess body fat increases
Colorectal, uterine, kidney, pancreatic and more
constantly from inflammation
Visceral fat releases estrogens
higher estrogen levels increase cell production, could result in tumor growth,”
Fat cells release proinflammatides
Ending thoughts?
Healthy lifestyle = diet AND exercise people.
healthy lifestyle can help prevent and treat diseases more than genetics
Not excuses for why youre unhealthy, find reasons and ways to change it
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