GeekWire

Chad Robins is a Cornell grad and Wharton School MBA who was working in real estate finance a decade ago when he was approached with a business idea by his brother, Harlan Robins, head of the Computational Biology Program at the Fred Hutchinson Cancer Research Center.

As Chad Robins recalled, "When he called me up in 2009 and said, 'Hey I want to start a business, I've figured out how to sequence T-cells at a high throughput,' I was like, 'Yes, I'm in!' and then I went to Wikipedia and I'm like, 'What the hell is he talking about?' I don't know the difference between a T-cell receptor and a T-bone steak."

A decade later, the company they created, Adaptive Biotechnologies, is using the genetic code of the immune system to change the diagnosis and treatment of disease. It’s valued at more than $1 billion. It has partnerships with industry giants Microsoft and Genentech, and this week it filed raise $230 million in an initial public offering. On this episode of the GeekWire podcast, we’ll get the inside story of Adaptive Biotechnologies and share what we learned in its IPO filing.

Correction 6/3: Chad Robins and Harlan Robins hold about the same amount of equity in the company, which wasn’t apparent from the IPO filing because some of the stock is held in trusts. We've update the audio to remove this portion of our discussion.

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Are we living in a simulation? Is there an afterlife? And if not, what would it take to create one? Drawing inspiration from Seattle's tech industry and the emerging field of virtual reality, best-selling science-fiction author Neal Stephenson knits together ideas as old as the Bible and as up-to-date as Elon Musk's musings in an epic 880-page novel titled "Fall; or, Dodge in Hell," due out June 4. GeekWire's Alan Boyle read the book and interviewed Stephenson, and joins us to share highlights.

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The peak home-buying season is upon us, but buyers and sellers taking a fresh look at the market will see a much different landscape for real estate technology than they did just a year or two ago -- and it's only the beginning of the changes to come. It's an exciting time in the real estate tech business, and anything can happen. On this special episode of the GeekWire Podcast, we assess the changes so far and debate what could happen next: Could Zillow end up buying Redfin or another brokerage to bolster its new model? Will the notion of one-click homebuying ever truly take hold? How will traditional brokerages play a role in the future? And will any of these changes actually address the fundamental problem of housing affordability? 

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Amazon's annual meeting has become a spectacle over the years, despite the company's best efforts to stick to business. Todd Bishop and Monica Nickelsburg explain what happened at this year's event, earlier this week in Seattle. Plus, the latest on T-Mobile and Sprint, why a former Facebook exec is floating Microsoft's Brad Smith as a replacement for Mark Zuckerberg, and how Rover capitalized on the Game of Thrones finale.

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John Rossman helped to launch and build the Amazon Marketplace business before leading the company's Enterprise Services business during his tenure at the company. In his new book, "Think Like Amazon: 50 1/2 Ideas to Become a Digital Leader," he helps other business leaders and managers understand, learn from and adopt elements of Amazon's approach. He sat down with us this week to talk about some of the ideas that define the company, and what they say about its future.

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Four years after acquiring Minecraft, Microsoft this week unveiled its most ambitious effort yet to take the popular franchise to the next level, and specifically into the real world. GeekWire went hands on with the game in a sneak preview, but with the release not expected until later this summer, why the heck is Microsoft touting this game before the rest of us can actually play it? 

Plus, Amazon is offering its employees an incentive to quit their jobs, if they start their own package delivery companies. This is the latest wrinkle in the company's Delivery Service Partners program, which we explored in depth last year. 

Finally, on the Random Channel, the latest twist in our quest to stream live audio at the ballpark, a commentary on the sequestering of tech execs, and the latest in the scooter saga, featuring Washington Gov. Jay Inslee.

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Listen in on our conversation with Melinda Gates, co-chair of the Bill and Melinda Gates Foundation, about her book, "The Moment of Lift: How Empowering Women Changes the World." The book has garnered national attention and further elevated Melinda's status as an influential public figure in her own right. GeekWire's Monica Nickelsburg and Todd Bishop spoke with Melinda at her office in Seattle, at the conclusion of her national book tour. Go to GeekWire.com for full coverage.

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How does Jeff Bezos plan to get to the moon, and what will he do after that? On this special bonus edition of the GeekWire Podcast, aerospace and science editor Alan Boyle calls in from Washington, D.C., where he covered the Amazon founder's unveiling of the new Blue Moon lunar lander from his Blue Origin space venture, aiming to put humans back on the moon by 2024 as part of a broader plan to colonize space. Plus, audio highlights from Bezos's talk.

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There's a common theme running through the spring season of developer conferences and tech events: trust and privacy.

With the tech industry faceing a backlash from consumers and regulators, tech giants including Facebook, Google, Apple and Microsoft are looking to assure everyone that they're listening. But each company is approaching the issue in a very different way, and with a very different track record on the topic.

On this episode of the GeekWire Podcast, we listen to the CEOs of these companies talk about privacy, and analyze the different approaches.

Other stories covered on this episode:

• Seattle will launch a scooter-share pilot — if providers agree to key safety and liability conditions
• On the other side of the state, Spokane’s tech scene capitalizes on Seattle squeeze
• ‘Game of Thrones’ gets roasted for leaving a Starbucks coffee cup in a shot during episode four

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The strength and success of the people and companies across the Pacific Northwest tech ecosystem was on full display Thursday night at the GeekWire Awards. GeekWire's Jonathan Sposato, John Cook and Todd Bishop share highlights and clips from the night on this episode of the GeekWire Podcast. More highlights here.

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