Healio Minute

In this edition, radiation is a 'strong alternative' for surgery, FDA approves combination therapy for small cell lung cancer and more.

Read the full coverage here:

Radiation a 'strong alternative' to surgery for early-stage lung cancer

FDA approves lurbinectedin, atezolizumab combination for small cell lung cancer

Diagnostic yield high with robotic-assisted bronchoscopy in peripheral lung lesions

Machine learning model predicts urgent care visits during lung cancer treatment

Evidence is 'clear': Medicaid expansion significantly improves long-term cancer survival

References:

Gonzalez BD, et al. JCO Clin Cancer Inform. 2025;doi:10.1200/CCI-24-00315.

Kleber T, et al. Abstract 268. Presented at: ASTRO Annual Meeting; Sept. 27-Oct. 1, 2025; San Francisco.

Press Release

Schafer EJ, et al. Cancer Discov. 2025;doi:10.1158/2159-8290.CD-25-1244.

Steinack C, et al. OA1178: Robotic-assisted bronchoscopy with integrated cone-beam CT vs. conventional bronchoscopy for diagnosing peripheral pulmonary lesions: An open-label randomized controlled trial. Presented at: European Respiratory Society International Congress; Sept. 27-Oct. 1, 2025; Amsterdam.

In this edition, bioinductive implants for ACL reconstruction, osteochondral defects treatments and more.

Read the full coverage here:

ACL reconstruction with reinforced bioinductive implant may yield favorable outcomes

Multiplug, single-plug techniques had comparable outcomes for osteochondral defects

MRI-based clinical prediction model identified risk factors for patellar instability

New technology, cost strategies continue to move robotic-assisted surgery forward

Physician referral to physical therapy underutilized for patients with knee osteoarthritis

References:

Healio Interviews

Khoja SS, et al. Arthritis Care Res. 2025;doi:10.1002/acr.25630.

McMillan S, et al. Surg Technol Int. 2025;doi:10.52198/25.STI.45.OS1888.

Mufti YN, et al. Am J Sports Med. 2025;doi:10.1177/03635465251352172.

Nukala V, et al. Arthrosc Sports Med Rehabil. 2025;doi:10.1016/j.asmr.2025.101159.

In this edition, we look at AI bias, nonsurgical biologic therapies and more.

Read the full coverage here:

'Math, not magic': Identify and combat bias in AI

Orthobiologics: Commit to evidence-based practice, foster cautious optimism

TJR indications expand, making it a young man's game

Successful management of PJI occurred in about 50% of patients

Risks of anteromedial tibial tubercle transfer are minimal and the benefits great

References:

Expert Submission

Healio Interviews

Higuera Rueda C, et al. Paper 1409. Presented at: Musculoskeletal Infection Society Annual Meeting; Aug. 1-2, 2025; Jersey City, N.J.

Engagement Time: 18 minutes

In this edition, FDA approves subcutaneous chemotherapy for solid tumors, improvements to shared decision-making and more.

Read the full coverage here:

FDA approves Hernexeos as first oral therapy for NSCLC with HER2 mutations

Communication, knowledge critical to improve shared decision-making for lung cancer

Detection of ctDNA could help determine use of immunotherapy for small cell lung cancer

Subcutaneous amivantamab plus lazertinib produces similar results to IV regimen in NSCLC

Lung cancer screening guidance needed for certain never-smokers

References:

Bi N, et al. Abstract 2034. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona.

Press Release

Scott SC, et al. Abstract 1798. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona.

Shum E, et al. Abstract 2172. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona.

Villalon D, et al. Abstract 2368. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona.

In this edition, ultra-processed grains linked to elevated risk for IBD, CTA use for GI bleeds increase and more.

Read the full coverage here:

Ultra-processed grains linked to elevated risk for IBD, especially ulcerative colitis

'Double whammy:' CTA use for GI bleeds rise, but diagnostic yield drops

'Another layer of benefit': GLP-1s linked to lower risk for peptic ulcer disease

'Simplified care models' needed for chronic HBV care to meet 2030 global elimination goals

'Stay vigilant': Routine exposure to AI may reduce ADR in standard colonoscopy

References:

Budzyń K, et al. Lancet Gastroenterol Hepatol. 2025;doi:10.1016/S2468-1253 (25) 00133-5.

Narula N, et al. Am J Gastro. 2025;doi:10.14309/ajg.0000000000003700.

Prasad S, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.29746.

Seika P, et al. Clin Gastroenterol Hepatol. 2025;doi:10.1016/j.cgh.2025.08.015.

Stockdale AJ, et al. Lancet Gastroenterol Hepatol. 2025;doi:10.1016/S2468-1253(25)00163-3.

In this edition, we look at labral reconstruction in adolescents, the risk of skipping breakfast on osteoporotic fractures and more.

Read the full coverage here:

Labral reconstruction yielded favorable outcomes among adolescent patients

Skipping breakfast, eating late dinners may raise risk for major osteoporotic fractures

AI may personalize patient care, identify surgical risks

Surgical fixation for pickleball-related Achilles ruptures may improve quality of life

Screening for osteoporosis, preventing fractures essential in diabetes care

References:

Chen C, et al. Paper 17. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn

Domb BG, et al. Paper 50. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn.

Kemmis K. Presentation D27. Presented at: ADCES25; Aug. 8-11, 2025; Phoenix.

Nakajima H, et al. J Endocr Soc. 2025;doi:10.1210/jendso/bvaf127.

Weight C. AI in the OR: Personalizing care, lowering complications and automating surgery. Presented at: Cleveland Clinic's A.I. Summit for Healthcare Professionals; July 11, 2025; Cleveland.

In this edition, we look at the risk orthopedic surgeons face from insufficient malpractice coverage, the role of AI in osteoporosis and more.

Read the full coverage here:

AI-assisted diagnostic system may identify osteopenia, osteoporosis

Insufficient malpractice coverage may place surgeons caring for elite athletes at risk

Psychological readiness, stress improved 2 years after ACL reconstruction

Patella resurfacing reduced maltracking, had comparable outcomes as nonresurfacing

Patellofemoral osteochondral allograft transplantation may effectively treat lesions

References:

Jolissaint JE, et al. Paper 1538. Presented at: Musculoskeletal Infection Society Annual Meeting; Aug. 1-2, 2025; Jersey City, N.J.

Milewski MD, et al. Paper 57. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn.

Moro T, et al. J Orthop Res. 2025;doi:10.1002/jor.70000.

Ramkumar PN, et al. Paper 37. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-13, 2025; Nashville, Tenn.

Wang T, et al. Paper 28. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn.

In this edition, FDA approves first oral therapy for NSCLC, interstitial lung disease diagnosis raises risk for lung cancer and more.

Read the full coverage here:

FDA approves Hernexeos as first oral therapy for NSCLC with HER2 mutations

ILD diagnosis raises risk for lung cancer

Uninsured patients benefit less from immune checkpoint inhibitors than privately insured

Shared decision-making visit improves annual lung cancer screening adherence

Indoor tobacco, e-cigarette use more common in rural vs. urban homes

References:

Chung Y, et al. CHEST. 2025;doi:10.1016/j.chest.2025.06.026.

Press Release

Steinberg AW, et al. Ann Am Thorac Soc. 2025;doi:10.1513/AnnalsATS.202504-419OC.

Xu H, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.19630.

Zhao J, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.19274.

In this edition, opioid deaths with GI issues tripled in the past decade, prophylactic vancomycin may reduce risk for recurrent C. difficile and more.

Read the full coverage here:

'Deeply alarming': Opioid deaths with GI issues tripled in the past decade

Prophylactic vancomycin may reduce risk for recurrent C. difficile

CRC disparities in Black communities stem from access, not biology, experts say

Mediterranean, plant-based diets linked to lower risk for chronic constipation

Psychiatric disorders 'common' among patients with inflammatory bowel disease

References:

Appiah JK, et al. Cureus. 2025;doi:10.7759/cureus.86489.

Cadogan K, et al. Crohns Colitis 360. 2025;doi:10.1093/crocol/otaf035.

Keating JA, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.17834.

May FP, et al. Nat Rev Gastroenterol Hepatol. 2025;doi: 10.1038/s41575-025-01087-3.

Wang Y, et al. Gastroenterology. 2025;doi:10.1053/j.gastro.2025.06.020.

In this edition, we look at how state opioid cap laws impact total joint replacements, how nutrition affects orthopedic surgery and more.

Read the full coverage here:

State opioid cap laws may reduce opioid fills after total joint replacement

Nutrition may be key to muscle, bone health after surgery

Should malnutrition screening occur before orthopedic surgery?

Pyrocarbon hemiarthroplasty with glenoid reaming may improve outcomes for young patients

Physicians under pressure in name, image and likeness era

References:

Expert Submission

Healio Interviews

Healio Interviews

Ranieri R, et al. J Shoulder Elbow Surg. 2025;doi:10.1016/j.jse.2024.06.028.

Thirukumaran CP, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.4448.