Harlan outlines his new study tracking excess mortality over the course of the pandemic in the highly vaccinated state of Massachusetts; Howie discusses how the Inflation Reduction Act will tackle drug prices. They're joined by Dr. Esther Choo to talk about life as a doctor on social media and the crisis facing emergency departments.

Links:

Esther Choo: "Covid-19 is pushing doctors to the brink. Medicine needs to recognize they're human and need help."

"Uncoupling of all-cause excess mortality from COVID-19 cases in a highly vaccinated state"

"New York Governor Lifts Mask Mandate for NYC Subways"

White House Fact Sheet: The Inflation Reduction Act Supports Workers and Families

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Monkeypox, polio, and COVID-19 have all received the World Health Organization's rarely used global health emergency designation. Howie and Harlan offer a needed sense of proportion alongside health information, updates on research, and policy developments for the grim trio of diseases.

Howie and Harlan talk with Dr. James Hamblin, a journalist and a lecturer at the Yale School of Public Health. They discuss his approach to communicating about public health, his prescient February 2020 article on COVID-19, and why he's quit taking showers.

Links:

James Hamblin: The Body

"You're Likely to Get the Coronavirus"

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Howie and Harlan are joined by Teresa Chahine, the Sheila and Ron '92 B.A. Marcelo Senior Lecturer in Social Entrepreneurship at Yale SOM. They discuss how social entrepreneurs use an interdisciplinary, iterative, community-centric approach to innovation to create self-sustaining solutions to problems in public health and other areas.

Links:

"Tirzepatide Once Weekly for the Treatment of Obesity"

Teresa Chahine: "Toward an Understanding of Public Health Entrepreneurship and Intrapreneurship"

Teresa Chahine: Social Entrepreneurship: Building Impact Step by Step, 2nd Edition (December 2022)

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Howie and Harlan discuss Harlan's large new study tracking the trajectory of patient safety in hospitals, and consider how individuals should respond to the latest COVID-19 variants. They're joined by Jennifer Miller, a Yale bioethicist and the director of the Good Pharma Scorecard, which evaluates the performance of pharmaceutical companies on measures like the transparency of clinical trials and the accessibility of medicines.

Links:

"New Federal Study Evaluates the Safety of US Hospitals and the Answer Is…"

"Trends in Adverse Event Rates in Hospitalized Patients, 2010-2019"

Good Pharma Scorecard

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Howie and Harlan discuss a concerning new COVID-19 variant, the discovery casting doubt on a major fish-oil study, and the need for new models of funding research.

Links:

"New Omicron subvariant Centaurus could be the most immune-evasive yet, expert warns"

"Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia"

"Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy"

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Harlan reviews the latest COVID-19 research, and Howie reflects on the vast ramifications of the Dobbs decision overturning Roe v. Wade. They're joined by Dr. Rebekah Gee, an ob-gyn and the CEO of Nest Health, which aims to deliver care to vulnerable children and their parents at home. She also describes her experience as a pro-choice physician serving as secretary of the Louisiana Department of Health.

Links:

Rebekah Gee discusses letters from her late mother on This American Life.

About Nest Health

"The War On Abortion Could Turn The US Into A Police State"

"The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment"

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Howie and Harlan are joined by Yale epidemiologist and MacArthur 'genius' Gregg Gonsalves to discuss his non-traditional route to improving responses to global public health challenges.

Links:

Eric Topol on COVID reinfections

Harlan's Twitter thread on insurance debt

"Health Savings Accounts No Longer Promote Consumer Cost-Consciousness" Sherry Glied in Health Affairs

The Best Little Boy in the World

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Harlan interviews Howie about his life as a doctor and teacher, including how a radiologist without a PhD got to teach economics at Yale, why he engages in the daily battles that come with speaking out on Twitter, and the extraordinary return on investment from time spent mentoring young people.

Links:

Arnold Schwarzenegger on deaths attributable to pollution

"Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit"

"Climate Change, Fossil-Fuel Pollution, and Children's Health"

Merriam-Webster on the origin of the word "doctor"

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Howie and Harlan are joined by Dr. Seth Trueger of Northwestern University, who was diagnosed with a rare autoimmune disorder in 2020. They discuss his experience navigating the healthcare system as a patient and what he's learned about the challenges facing people with complex medical issues.

Links:

2022 Medicare Trustees Report

"A Cancer Trial's Unexpected Result: Remission in Every Patient"

"PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer"

Seth Trueger: "The Best Bad News"

"Public Finance Balance of Smoking in the Czech Republic"

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