Dr. Vivek Subbiah returns for another edition of Vivek's Takes, sharing his insights on key updates from ESMO Congress 2024, including breakthroughs in neuroendocrine tumors, gastric cancer, and non-small cell lung cancer. He also delves into the highlights of his AACR debate on integrating early cancer detection with AI, arguing for the transformative potential of humans with AI versus the readiness of AI today. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi welcomes Dr. Andrea Apolo, an internationally recognized leader in bladder cancer research from the National Cancer Institute. Dr. Apolo shares her expertise on recent advancements in urothelial cancer therapy, including key breakthroughs in checkpoint inhibition that have marked a significant turning point in treatment. The conversation delves into optimal sequencing and combination strategies for checkpoint inhibitors, contrasts in treatment approaches between early-stage and late-stage disease, and the evolving landscape of bladder-sparing options. Dr. Apolo also provides an in-depth look at the comprehensive process of designing, executing, and publishing impactful clinical research, highlighted by her latest publication in The New England Journal of Medicine.Read more about her NEJM trial.https://www.nejm.org/doi/abs/10.1056/NEJMoa2401726 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Joe Mikhael, Chief Medical Officer of the International Myeloma Foundation (IMF) and Professor at TGen, takes us beyond his medical career to explore the personal experiences that have shaped his journey in oncology. Dr. Mikhael discusses the IMF’s targeted strategies for reducing health disparities among diverse ethnic and racial groups affected by myeloma, shedding light on specific initiatives aimed at improving access and outcomes. He also dives into his role in medical education, where he mentors the next generation of oncologists through innovative fellowship programs, advancing research, and fostering a more inclusive approach to cancer care.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Tom Beer, Chief Medical Officer of the Multi-Cancer Early Detection (MCED) program at Exact Sciences, delves into the groundbreaking science behind MCED tests, which use advanced biomarkers for early detection of multiple cancer types. He explains who may be eligible for these tests, how to interpret results to avoid unnecessary intervention from over-detection, and the varying sensitivity levels of MCED tests across different cancers. Additionally, Tom shares insights into the Falcon trial – a major real-world study assessing a MCED test clinical performance and potential impact on early cancer detection and patient outcomes.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this special episode, Chadi gives up the microphone to guest host Kelly Ryerson, who takes over the show asking questions about Chadi's new book "The Cancer Journey."What inspired the book writing? What methods are used? Who is the target audience? What did the author learn? And what did he aim to achieve?Written for everyone who wants to learn more about cancer, this discussion highlights behind-the-scenes information on Chadi's latest achievement.View more and order “The Cancer Journey.”chadinabhan.com/the-cancer-journey/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Jon Chait never thought he would get cancer, but one day he found he had it. As he navigates his journey alongside his caregiver and wife Heather, he shares with Chadi the good and the bad, the ups and downs, and what he encounters in a broken, complex healthcare system.A fitting episode as Chadi launches his book "The Cancer Journey." It is a must listen to anyone navigating the system. Is it truly patient-centric as advertised?You be the judge.View more and order “The Cancer Journey.”https://chadinabhan.com/the-cancer-journey/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Kathy Giusti, founder of the Multiple Myeloma Research Foundation (MMRF) and a two-time cancer survivor, opens up about her first diagnosis and the life-changing conversation with her primary care doctor. She reflects on the overwhelming "age of information," which often leads patients to more questions than answers, and shares her strategies for dealing with the loss of control that comes with a cancer diagnosis. Kathy also talks about the importance of identifying what truly matters, placing personal priorities in plain sight as daily reminders. She delves into the potential next breakthrough in multiple myeloma research, her success in engaging patients in MMRF’s direction, and offers heartfelt advice for families on when and how to tell children about a cancer diagnosis, as well as other important points through the cancer journey, drawing from her own deeply personal experiences.Read more about the Kathy Giusti story.https://www.statnews.com/2024/09/03/multiple-myeloma-kathy-guisti-fatal-to-fearless-patient-advocate-research-fundraiser/Find out more about Kathy’s book “Fatal to Fearless.”https://www.kathygiusti.com/bookCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Joe Lennerz, Chief Scientific Officer of BostonGene and a pathologist by training, joins Chadi to break down next-generation sequencing (NGS) in simple terms, discussing why some patients undergo NGS while others do not, along with its advantages and limitations. He also explores the impact of NGS on treatment pathways, the practicality of minimal residual disease (MRD) detection, liquid biopsy, and circulating tumor DNA (ctDNA), and whether immediate action should be taken after MRD detection. Additionally, Dr. Lennerz examines multi-cancer early detection technologies, who should be tested, and the future need for regulatory oversight in this rapidly advancing field.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Sanjay Patel of Weill Cornell and Dr. Greg Goldgof of Memorial Sloan Kettering dive into the transformative role of AI in modern pathology. They discuss how large language models are enhancing diagnostic workflows, expediting report synthesis, and shaping the future of patient care. The conversation also touches on the complex training required to ready AI systems for clinical use, the areas of pathology most impacted by AI today, and how this technology is being integrated into the education of future pathologists.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

David Canes, CEO of WellPrept and a Boston-based urologist, joins the show to share the story behind his innovative platform designed to reduce physician burnout. He explains how WellPrept empowers doctors to streamline patient education by organizing and delivering tailored materials before the first visit, allowing for more personalized and efficient consultations. David also touches on his entrepreneurial journey, the platform's future expansion beyond urology, and the broader impact WellPrept could have across all medical specialties.Find out more about WellPrept.https://wellprept.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA