Joining host Chadi is the esteemed James LaBelle, MD, PhD, Associate Director of Pediatrics and Director of the Stem Cell and Cellular Therapy Program at the University of Chicago. Dr. LaBelle elucidates the complexities of sickle cell disease, unraveling the devastating impact it has on individuals. The episode delves into various treatments and approaches to combat this formidable disease, including bone marrow transplant and the groundbreaking use of CRISPR-Cas9 technology. LaBelle shares insights into the recent research breakthroughs, citing the remarkable research report published in the New England Journal of Medicine, showcasing the successful application of CRISPR-Cas9 for sickle cell disease. This episode serves as a gateway into the promising future of genetic therapies.

Read Dr. LaBelle’s publication on CRISPR-Cas9 in NEJM.

https://www.nejm.org/doi/full/10.1056/NEJMoa2215643

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In a poignant episode, USA Today investigative journalist Emily Le Coz unravels the heart-wrenching narrative of Ashleigh Anderson, a CVS pharmacist whose tragic demise serves as a cautionary tale of overwhelming stress in the workplace. Emily shares her motivations behind delving into the pervasive issue of burnout in retail pharmacy and sheds light on the very real threat it poses. She recounts the details of the Ashleigh Anderson story, where the toxic culture within retail pharmacy played a pivotal role in a life lost to the pressures of the job. Together, Chadi and Emily Le Coz navigate the profound implications of burnout, exploring its dangers and the urgent need for systemic change within the retail pharmacy landscape. This episode serves as both a tribute to Ashleigh Anderson and a rallying cry for reform in an industry grappling with the devastating consequences of unchecked workplace stress.

Read more about the Ashleigh Anderson story.

https://www.usatoday.com/story/news/investigations/2024/02/08/cvs-pharmacist-ashleigh-anderson-death-rallying-cry/72406578007/

Read another piece by Emily Le Coz.

https://www.usatoday.com/story/news/investigations/2023/10/26/pharmacy-chains-dangerous-conditions-medication-errors/71153960007/

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Joining host Chadi is a trio of esteemed guests – Drs. Andy Evans, Matt Maurer, and Susan Parsons – of the HoLISTIC (Hodgkin Lymphoma International Study for Individual Care) Consortium. In this riveting conversation, they delve into the consortium's pioneering efforts, bringing together an international team of experts to scrutinize the multifaceted dimensions of Hodgkin lymphoma, spanning prognosis, epidemiology, treatment, survivorship, and health outcomes across all age groups. The discussion circles around consensus protocols for treatment, referral pathways, and clinical trials, probing the necessity of transplants in the era of novel therapeutics and the creation of predictive models tailored to individual patient needs. Tune in to hear about the meticulous efforts invested in building the HoLISTIC portal, automating data migration, and navigating the challenges and progress in predictive modeling for treatment selection, response, and failure. This episode offers a captivating exploration of how collaboration, technology, and data analysis converge to shape the future of Hodgkin lymphoma care.

Find out more about the HoLISTIC Consortium.

https://www.hodgkinconsortium.com/

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In the latest installment of the ABIM Maintenance of Certification (MOC) saga on Healthcare Unfiltered, the fiery aftermath of Aaron Goodman's groundbreaking petition to dismantle the ABIM MOC takes center stage. Joined by recurring guests, the outspoken Drs. Wes Fisher, Vincent Rajkumar, and Aaron Goodman himself, Chadi dives deep into the shifts within the medical landscape over the past six months. The conversation unfolds with a critical analysis of medical societies' responsiveness to the petition, exploring whether genuine change is underway or if inertia prevails. Together, they passionately discuss the crucial role of hospital and institution-wide rejection in catalyzing a domino effect for change. The episode doesn't shy away from the legal battlefield either, delving into the multiple class-action anti-trust cases against ABIM MOC. Tensions rise throughout the conversation, but it concludes with a collective focus on the next steps to propel this movement forward.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In a highly-anticipated comeback, Dave Feldman, the seasoned senior software engineer and entrepreneurial mind, delves into uncharted territories of the keto diet, cholesterol dynamics, and lipids, unveiling a riveting discourse intricately intertwined with a novel cardiac study. Feldman unfolds the layers of his personal journey with the keto diet, evolving into a recognized authority on lipids. He showcases the intriguing sequence of events that propelled him to design a study involving cardiac tests and a cohort of 100 patients committed to a low-carb, keto lifestyle for over a year. Could this study revolutionize the way cardiologists and primary care providers approach cholesterol management? Will it unveil evidence challenging the conventional prescription of statins to lower LDL?

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Salma Jabbour, MD, Professor and Vice Chair of Radiation Oncology at Rutgers Cancer Institute, provides an invaluable perspective rooted in her extensive experience and passion for radiation oncology. Dr. Jabbour delves into the transformative changes witnessed in radiation oncology over the past two decades, contrasting its trajectory with precision oncology. She shares compelling insights into the PROSPECT trial's innovative approach of omitting radiation therapy entirely for rectal cancer patients, emphasizing the "impressive" results unveiled in the study. Then, the New York Times articles characterizing radiation as "brutal" for patients in this context is considered, and Dr. Jabbour navigates the complexities, challenges, and potential paradigm shifts these findings might signal for the field.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content.

www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube.

www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Highlighting the complex and contentious world of non-compete clauses within the medical field, Dr. David Lankford, a pediatric intensivist, made headlines after challenging a non-compete clause in his contract with Lutheran Medical Group in Indiana. His lawsuit not only raises questions about the legality and ethical implications of such clauses, but also tests a new state law regarding physician non-competes. Dr. David Lankford is joined by Alex Pantos, an associate attorney integral to his case. Together, they provide deep insights into the legal intricacies, broader implications for healthcare professionals, and the potential impact of this legal battle on the medical community. The nuances and debates surrounding this pivotal case may reshape the landscape of physician contracts and professional mobility.

Read more about the lawsuit.

https://www.wfyi.org/news/articles/this-doctors-lawsuit-puts-a-new-physician-noncompete-state-law-to-the-test-heres-whats-at-stake

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Making his return to the show is Dr. Robert Califf, the current FDA Commissioner, this time to break down and offer insights into the Administration’s contentious accelerated approval pathway. Dr. Califf expands on the criticisms and concerns surrounding surrogate endpoints and confirmatory trials within the accelerated approval process, shedding light on the ongoing dialogue between the Administration and manufacturers regarding these crucial trials. He navigates through the intricacies of the Food and Drug Omnibus Reform Act, offering perspectives on the global use of drugs and devices post-negative results in confirmatory trials. Dr. Califf also emphasizes the imperative need for a revamped post-market evidence generation system while exploring various avenues for achieving this critical transformation.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Drs. Hossein Borghaei and Tony Calles dissect the pivotal abstracts and cutting-edge data unveiled at ESMO 2023, spotlighting the transformative landscape of lung cancer treatment. From exploring innovative immunotherapy combinations to the promising prospects of antibody-drug conjugates, they navigate through the complexities of neoadjuvant and adjuvant sequencing, shedding light on optimal therapeutic strategies. With a keen focus on targeted therapies and an array of other compelling studies, Drs. Borghaei and Calles decode the implications of these advancements, offering invaluable insights into reshaping the future of lung cancer care.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Steve Stavs, a “pro biohacker” and “health futurist,” unveils his model to combat chronic diseases by addressing root causes, while exploring Eastern medicine's approach to preventive care and its current standing in research and empirical evidence for complementary interventions. As a pro biohacker, Stavs shares insights on optimizing whole-body performance and health, highlighting the impact of internal and external factors on chronic diseases and differentiating between "getting old" and the process of "aging." With Chadi, he delves into dietary nuances, distinguishing between organic and processed foods, sodas, and their implications for overall health, presenting a holistic view of Chinese and Eastern medicine's potential in fostering a healthier lifestyle.

Read more about Steve Stavs.

https://stevestavs.com/

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA