EAB’s Meacie Fairfax and Ed Venit explore pandemic ripple effects that will continue to impact student persistence at colleges and universities for the foreseeable future. They cite studies showing that student feelings of isolation, disengagement, depression, and other mental health challenges—a growing concern for years—have all worsened during the pandemic. They also point to learning challenges that have plagued K-12 students during the pandemic, as well as the recent plunge in community college enrollments as additional headwinds that four-year institutions will be dealing with for years to come. On the positive side, Meacie and Ed highlight the opportunity facing higher ed leaders who have little choice but to modernize their approach to student retention and success.