Health care professionals tend to be traditional and conservative when it comes to practice, so incorporating new technologies and innovations into the hospital and the operating room can be a challenge. Four cardiothoracic surgery change drivers—Shanda H. Blackmon, MD, MPH, James D. Luketich, MD, T. Sloan Guy, MD, MBA, and Linda W. Martin, MD, MPH—provide advice on how to get buy-in from hospital administrators, as well as team members.