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How to Treat Diffuse Large B-Cell Lymphoma (DLBCL) in 2025
Welcome to the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain dive deep into the world of diffuse large B-cell lymphoma (DLBCL), one of the most aggressive yet potentially curable lymphomas. We are joined by Dr. John Leonard, a renowned lymphoma expert from NYU Langone Cancer Center, who shares his insights on the latest data and evolving treatment landscape for DLBCL.
Episode Highlights:
• Understanding the initial workup for DLBCL, including the role of PET-CT and bone marrow biopsies.
• The use of RCHOP and the emerging Pola-R-CHP regimen in Stage 1 and Stage 2 settings.
• Discussion on the treatment options for Stage 3 and Stage 4 disease, including the impact of polatuzumab.
• Insights into managing relapsed/refractory disease and the role of CAR-T therapy.
• The potential shift towards outpatient CAR-T treatments and the nuances between different CAR-T options.
• Exploring bispecific antibodies and their applications in treatment sequencing.
YouTube: https://youtu.be/raGkPnUs9XM
Follow us on social media:
• X/Twitter: https://twitter.com/oncbrothers
• Instagram: https://www.instagram.com/oncbrothers
• Website: https://oncbrothers.com/
Join us as we unpack the complexities of DLBCL treatment and share valuable clinical pearls for community settings. Don't forget to subscribe for more episodes on challenging cases and the latest in oncology!
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By Oncology Brothers
4.9
4242 ratings
Welcome to the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain dive deep into the world of diffuse large B-cell lymphoma (DLBCL), one of the most aggressive yet potentially curable lymphomas. We are joined by Dr. John Leonard, a renowned lymphoma expert from NYU Langone Cancer Center, who shares his insights on the latest data and evolving treatment landscape for DLBCL.
Episode Highlights:
• Understanding the initial workup for DLBCL, including the role of PET-CT and bone marrow biopsies.
• The use of RCHOP and the emerging Pola-R-CHP regimen in Stage 1 and Stage 2 settings.
• Discussion on the treatment options for Stage 3 and Stage 4 disease, including the impact of polatuzumab.
• Insights into managing relapsed/refractory disease and the role of CAR-T therapy.
• The potential shift towards outpatient CAR-T treatments and the nuances between different CAR-T options.
• Exploring bispecific antibodies and their applications in treatment sequencing.
YouTube: https://youtu.be/raGkPnUs9XM
Follow us on social media:
• X/Twitter: https://twitter.com/oncbrothers
• Instagram: https://www.instagram.com/oncbrothers
• Website: https://oncbrothers.com/
Join us as we unpack the complexities of DLBCL treatment and share valuable clinical pearls for community settings. Don't forget to subscribe for more episodes on challenging cases and the latest in oncology!
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