Oncology Today with Dr Neil Love

Featuring an interview with Dr L Elizabeth Budde, including the following topics:

• Considerations for selecting between bispecific antibodies (BsAbs); monotherapy versus combination therapy (0:00)
• Management of BsAb-induced cytokine release syndrome and other toxicities (7:35)
• Use of BsAbs in the front-line treatment of diffuse large B-cell lymphoma (DLBCL); key findings from the Phase II MorningSun study (17:30)
• Case: A man in his mid 50s with relapsed/refractory (R/R) DLBCL receives mosunetuzumab and polatuzumab vedotin in the second-line setting (23:18)
• Case: A woman in her early 70s with R/R DLBCL receives glofitamab monotherapy in the third-line setting (32:52)
• Case: A man in his early 80s with R/R DLBCL experiences disease progression after lisocabtagene maraleucel therapy, which was bridged with epcoritamab and gemcitabine/oxaliplatin (37:35)

CME information and select publications

Featuring perspectives from Dr Stephen V Liu and Dr Stephen "Fred" Divers, moderated by Dr Divers, including the following topics:

• Introduction (0:00)
• EGFR Mutations (2:23)
• HER2 Alterations (22:40)
• Available and Investigational Immunotherapies (32:14)
• Small Cell Lung Cancer (40:48)

CME information and select publications

Featuring an interview with Dr Neeraj Agarwal, including the following topics:

• Impact of PTEN deficiency on PI3K/AKT/mTOR pathway; optimal approaches to testing (0:00)
• Approaches to monitoring for disease progression in patients who are PTEN deficient; prognostic significance and implications for testing (7:13)
• Potential usage of capivasertib as second-line therapy for metastatic androgen pathway modulation-naïve/-sensitive (APMN/S) prostate cancer (15:15)
• Managing treatment-related adverse events from capivasertib (20:08)
• Case: A man in his late 50s diagnosed with metastatic APMS prostate cancer and a PTEN deficiency who receives capivasertib (29:17)
• Case: A man in his late 70s diagnosed with high-volume metastatic APMN prostate cancer and a PTEN deficiency who experiences disease progression on androgen deprivation therapy and enzalutamide (40:39)

CME information and select publications

Featuring perspectives from Dr Joyce F Liu, Dr David M O'Malley and Dr Brian M Slomovitz, moderated by Dr O'Malley, including the following topics:

• Case: A woman in her mid 60s with metastatic serous endometrial carcinoma that is HER2 IHC 3+ who received first-line carboplatin/paclitaxel/trastuzumab and second-line trastuzumab deruxtecan — Ursula Matulonis, MD (0:00)
• Commentary: Role of HER2-directed therapy in the maintenance setting for patients with HER2-positive disease — Professor Jonathan A Ledermann (12:29)

CME information and select publications

Featuring perspectives from Dr Ann LaCasce and Dr Stephen "Fred" Divers, moderated by Dr Divers, including the following topics:

• Introduction (0:00)
• First-Line Treatment (1:33)
• Bispecific Antibodies and Chimeric Antigen Receptor T-Cell Therapy (20:36)

CME information and select publications

Featuring perspectives from Dr Shannon N Westin and Dr Stephen "Fred" Divers, moderated by Dr Divers, including the following topics:

• Introduction (0:00)
• Ovarian Cancer (2:22)
• Endometrial Cancer (37:48)

CME information and select publications

Featuring an interview with Dr Alexander E Drilon, including the following topics:

• Overview of targetable biomarkers in lung cancer (0:00)
• Biomarker testing for genomic alterations in lung cancer (5:24)
• Overview of ROS1 alterations in lung cancer (13:44)
• Efficacy data with ROS1 inhibitors for lung cancer (17:02)
• Safety data with ROS1 inhibitors for lung cancer (21:15)
• Case: A woman in her early 50s with a history of non-small cell lung cancer (NSCLC) undergoes biomarker testing to reveal a ROS1 fusion (28:56)
• Case: A man in his late teens diagnosed with de novo advanced NSCLC with a ROS1 alteration achieves a dramatic response to therapy (46:16)
• Case: A woman in her early 60s with a history of ROS1-altered NSCLC receives several ROS1 inhibitors (50:52)

NCPD information and select publications

Featuring an interview with Professor Nicoletta Colombo, including the following topics:

• Mechanistic effects and rationale underlying the use of relacorilant/nab paclitaxel (0:00)
• Rationale underlying the study design of the Phase II BELLA trial and avenues for future exploration (8:31)
• Definition of platinum ineligibility; importance of platinum-containing chemotherapy for patients with ovarian cancer (14:02)
• Findings from a Phase II trial and the subsequent confirmatory Phase III ROSELLA study (20:25)
• Phase III ROSELLA study: Subgroup analyses, patient-reported outcomes, insights into overall survival data and common adverse events (29:43)
• Considerations for therapeutic selection and sequencing of novel therapies; ongoing and future investigations (38:46)

CME information and select publications

Featuring perspectives from Dr Samuel J Klempner and Dr Stephen "Fred" Divers, moderated by Dr Divers, including the following topics:

• Introduction (0:00)
• First-Line Treatment of Metastatic Gastroesophageal Cancer (1:48)
• Management of HER2-Positive Gastroesophageal Cancer (25:11)
• Neoadjuvant Therapy for Gastroesophageal Cancer (45:13)

Note to listeners: Subsequent to the recording of this symposium, the FDA approved zanidatamab in combination with chemotherapy with and without tislelizumab for HER2-positive gastric, gastroesophageal junction, or esophageal adenocarcinoma based on results from the Phase III HERIZON-GEA-01 trial.

CME information and select publications

Featuring perspectives from Dr Farrukh T Awan and Dr Stephen "Fred" Divers, moderated by Dr Divers, including the following topics:

• Introduction (0:00)
• First-Line Therapy (2:48)
• Relapsed/Refractory Disease (39:30)

CME information and select publications