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In this episode of the Red Journal podcast, Anthony Zietman, MD, Editor in Chief interviews members of the HyTEC steering committee: Jimm Grimm, PhD, Larry Marks, MD, Ellen Yorke, PhD, and Andrew Jackson, PhD. The panelists discuss the origins of HyTEC, the approach used to develop their reports, how the team integrated models and clinical data, and what projects following HyTEC might look like. The HyTEC special issue of the Red Journal is available now online at redjournal.org.