Some common life-saving medicines, such as insulin, are made of proteins so large and fragile that they need to be injected instead of ingested as pills. But a new generation of medicine -- made from smaller, more durable proteins known as peptides -- is on its way. In a quick, informative talk, molecular engineer and TED Fellow Christopher Bahl explains how he's using computational design to create powerful peptides that could one day neutralize the flu, protect against botulism poisoning and even stop cancer cells from growing.
Chris Bahl is a protein designer, biochemist and structural biologist. Chris pioneered the ability to computationally design synthetic miniproteins de novo. He began this work at the Institute of Protein Design in Seattle as a postdoctoral fellow, and he matured this design technology into a high-throughput platform with his team at the Institute for Protein Innovation in Boston where Chris was the Head of Protein Design. Today, Chris is the Chief Scientific Officer and Co-founder of AI Proteins, Inc. AI Proteins is leveraging the unique and powerful synthetic miniprotein modality to rapidly create novel therapeutics.
AI Proteins is a newly founded biotechnology company focused on the design and engineering of synthetic miniprotein therapeutics. We combine cutting-edge computational protein design with advanced laboratory robotics to accelerate the creation of life-changing medicines. Our common goal is to markedly improve human health and wellbeing. Our environment is rigorous, fast-paced and collaborative, bringing together passionate individuals who are making an impact. We inspire creativity and discovery by embracing an open culture that fosters innovation, initiative, teamwork and excellence.
00:00 Introduction & the purpose of these medicines and how it all started
04:55 Why are mini proteins becoming known now
07:40 Why isn’t being used during the pandemic
09:42 How do you know if mini proteins are safe
& When to expect AiProteins on the market
16”17 Which diseases will be cured first
22:10 Others working on proteins
29:40 Proteins potential for the future
32:22 why not work with the military
36:40 Career advice to go in this industry
37:25 Moving from academia to pursue business
42:00 Matching with a suitable VC
45:25 Company growth and Difference with academia
51:24 Whats the future of medicine?
54:55 A plea to entertainers to help science
58:50 Closing & Where to find AiProteins
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