Nannie Doss, dubbed the "Giggling Granny," confessed to a decades-long killing spree, claiming the lives of eleven family members, including five husbands. Her crimes, spanning from 1927 to 1954, involved various methods of poisoning, leading to suspicion and investigation after the death of her last husband. Doss's initial death sentence was overturned due to a declaration of insanity, and she subsequently died of leukemia in prison. The case, initially sensationalized in the media, recently gained renewed attention on social media. Her story highlights the chilling contrast between her outwardly charming demeanor and her brutal actions.