Chances are that if any of us are looking to drop a bit of excess weight, the first thing we’ll attempt is to cut down the number of calories we’re consuming. For decades, we’ve been told that balancing the number of calories we put into to our bodies with the energy that we burn can help us to maintain a healthy weight. While this is true, could it be that we’re putting our attention and effort in the wrong place and that taking a bigger picture view of the factors that motivate our appetite is likely to be a much more successful strategy?

In this episode, we’re joined by Dr Jason Fung, a physician and best-selling author based in Toronto, to talk about his latest book, The Hunger Code – Resetting Your Body’s Fat Thermostat in the Age of Ultra-processed Food.

He talks us through the three key drivers that control our feelings of hunger, how our hormones are deeply connected with our appetites, and how the environments we live in have a profound effect on the food we eat.

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Around the world, more than 50 million people are living with some form of dementia – a number expected to triple by 2050 as populations age. But the thing is, dementia is often talked about as a kind of genetic lottery. You either get lucky and escape it, or unlucky and develop it. But what if that framing is wrong? What if far more of our brain health is within our control than we’ve been led to believe?

Our guest today is Dr Majid Fotuhi, a neuroscientist who has spent decades treating and studying people with cognitive impairment. His message is a bold one: dementia is largely preventable – not with a miracle pill or silver-bullet treatment, but through the way we live.

The 12-week programme he and his team have developed has helped his patients improve their memory, regain independence, and even grow new brain connections. Today, he talks us through the essentials of the programme – and what it really takes to stay sharp for life.

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Statistics show that half of us will experience a mental health condition of some kind by the time we turn forty. Could this be due to the increasing pressures and looming crises we’re currently facing in the modern world, overstimulating natural responses in our brains and bodies that have evolved over hundreds of thousands of years to protect us from threats?

In this episode, we’re joined by Dr Joanna Cheek, a psychiatrist, psychotherapist and clinical professor based at the University of British Columbia’s Faculty of Medicine, to talk about her latest book, It’s Not You, It’s the World – A Mental Health Survival Guide for Us All.

She tells us how the system of alarm signals in our brains is being increasingly triggered by the rapidly changing circumstances we find ourselves in, how this is hijacking the push and pull of our natural risk/reward systems, and why connecting more deeply with the rich tapestry of the people and cultures we share the world with can help us all bring our lives back into balance.

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Whether we’re working at a desk in an office, running a marathon or even asleep in bed, our bodies are host to thousands of chemical processes that are continually converting the food we eat into energy and repairing our bones, muscles and organs. Collectively these processes are known as the metabolism. But how are they affected by our genes, lifestyles and diet, and what can we do to make sure everything stays running smoothly?

In this episode, we’re joined by Javier Gonzalez, a professor of nutrition and metabolism based at the University of Bath.

He breaks down the links between our metabolisms and body types, tells us why our metabolisms aren’t necessarily fixed for life, and explains why it’s almost impossible to out exercise a poor diet if you’re looking to drop a few kilos.

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The human face contains more than 40 muscles, giving us an ability to visually express our thoughts and emotions that is unique in the animal kingdom. This has perhaps led to a long-held obsession to uncover the many mysteries of our faces that has persisted in everyone from artists, scientists and even anthropologists for thousands of years. But where is this trend heading? And is it doing more harm than good?

In this episode, we’re joined by Dr Fay Bound-Alberti, the founder of the Centre for Technology and the Body at King’s College London, to talk about her latest book, The Face: A Cultural History.

She tells us how the idea of the perfectly proportioned face that began in classical art continues to persist in today’s social media beauty trends, the various attempts that have been made over the years to determine a person’s good or bad qualities based on their facial characteristics, and explains the challenges we’re currently confronted by thanks to the rise of new technologies such as facial recognition.

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We often think of our planet as an isolated island, solitary and cut off from the cosmic ocean it resides in. But the truth is, Earth is intimately connected with the Universe surrounding it. What’s more, by learning more about the Solar System around us, humanity has changed its own view of the world as well. Dr Dagomar Degroot from Georgetown University spoke to us to explore this idea in more detail.

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For the last several billion years, all life on Earth has progressed according to the rules of evolution by natural selection – a step-by-step process that has given rise to the fascinating complexity and beauty of all the living things we share our planet with. But now, due to advances in our knowledge of genetics and the rise of artificial intelligence, we’re on the brink of being able to design living organisms from scratch. This new field of research is known as generative biology.

In this episode, we’re joined by Adrian Woolfson, a researcher who specialises in synthetic genome design, to talk about his latest book On the Future of Species – Authoring Life by Means of Artificial Biological Intelligence.

He tells us how this fascinating area of research is bringing us closer to a genuine scientific revolution that could change the way we think about how life is created, the vast implications that this may have on human health and the health of our planet, and why we all need to be aware of this powerful new technology and its potential.

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The chances are that if any of us were asked to describe what it feels like to be in love we’d turn to art, poetry or music to help give us the answer. But what does science have to say about this uniquely human experience?

In this episode, we’re joined by Dr Justin Garcia, an evolutionary biologist and sex researcher based at the Kinsey Institute in the US, to talk about his book, The Intimate Animal: The Science of Love, Fidelity and Connection

He tells us how the evolutionary history of human pair bonding led to the development of our feelings of love, how and why we seek certain characteristics in our romantic partners, and how our attitude to relationships has altered due to changes in thinking, culture, and technology.

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Over the past several decades, many technologists and policy makers have sought out huge, disruptive shifts in thinking in almost every area of science, business and commerce in the hope that they’d help to drive innovation forward in giant leaps, one brilliant new idea at a time. But how successful has this been, and should we instead be focusing on a more gradual, incremental approach to innovation that’s based on the steady upgrading of the systems we already have in place?

In this episode, we’re joined by Albert Fox-Cahn, a visiting professor at The Centre of Governance and Human Rights at Pembroke College, Cambridge, to talk about his latest book Move Slow and Upgrade – The Power of Incremental Innovation.

He tells us why we tend to overemphasise the potential impact of the Next Big Thing, how this often leads to a rush to adopt unproven, and at times, unsafe new technologies, and how applying evidence-based thinking and an upgrader’s mindset can help us to be more like the tortoise than the hare, and ultimately win the race.

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If most of us are put on the spot and asked to name acts that we think would define a person as evil, it’s likely our minds would turn to murderers, rapists and war criminals, to name a few. But could it be that this commonly held conception of evil isn’t merely just an oversimplification, but rather a deeply flawed way of viewing the world based on a litany of personal biases, and one that is in dire need of readdressing?

In this episode, we’re joined by Dr Julia Shaw, a broadcaster, best-selling author and psychologist based at University College London to talk about the nature of evil.

She tells us why it’s vital that we accept that, given a certain set of circumstances, we’re all capable of committing terrible acts, explains the key differences between thought and action, and explains why so many of us are fascinated by true crime documentaries and dramas.

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