The Effective Statistician - in association with PSI

Introduction to Dealing with Non-proportional Hazards


Listen Later

Interview with Kaspar Rufibach
Key points:
  • Non-Proportional Hazards: Understanding when and why the proportional hazards assumption fails.
  • Hazard Functions: Differences between survival functions and hazard functions; interpreting dynamics over time.
  • Data Visualization: Importance of visualizing hazard functions alongside Kaplan-Meier curves.
  • Clinical Context: Collaborating with clinicians to understand treatment effects and disease dynamics.
  • Effect Quantification: Exploring alternatives to hazard ratios when proportionality doesn’t hold.
  • Trial Design: Challenges in designing studies with non-proportional hazards and strategies to address them.
  • Simplification Risks: Avoiding oversimplifications like responder analysis or arbitrary sample size increases.
  • Stakeholder Communication: Explaining complex survival data effectively to non-statisticians.
  • Regulatory Considerations: Balancing valid hypothesis testing with meaningful effect quantification.
  • Actionable Insights: Practical steps for statisticians to improve survival analysis and trial design.
  • Dealing with non-proportional hazards is a complex but critical aspect of survival analysis, and understanding it can make a significant difference in your work. In this episode, Kaspar and I covered everything from hazard functions and survival curves to practical strategies for trial design and effect quantification. If you found these insights valuable, don’t keep them to yourself!

    Share this episode with your friends and colleagues who work with survival analysis or clinical trials. And if you haven’t already, make sure to subscribe so you never miss an episode of The Effective Statistician. Let’s work together to elevate the impact of statistics in healthcare!

    ...more
    View all episodesView all episodes
    Download on the App Store

    The Effective Statistician - in association with PSIBy Alexander Schacht and Benjamin Piske, biometricians, statisticians and leaders in the pharma industry

    • 4.4
    • 4.4
    • 4.4
    • 4.4
    • 4.4

    4.4

    9 ratings


    More shows like The Effective Statistician - in association with PSI

    View all
    Stuff You Should Know by iHeartPodcasts

    Stuff You Should Know

    78,338 Listeners

    Freakonomics Radio by Freakonomics Radio + Stitcher

    Freakonomics Radio

    32,082 Listeners

    Planet Money by NPR

    Planet Money

    30,647 Listeners

    Hidden Brain by Hidden Brain, Shankar Vedantam

    Hidden Brain

    43,572 Listeners

    Pivot by New York Magazine

    Pivot

    9,483 Listeners

    JAMA Clinical Reviews by JAMA Network

    JAMA Clinical Reviews

    497 Listeners

    HBR IdeaCast by Harvard Business Review

    HBR IdeaCast

    162 Listeners

    Page 94: The Private Eye Podcast by Page 94: The Private Eye Podcast

    Page 94: The Private Eye Podcast

    343 Listeners

    The Peter Attia Drive by Peter Attia, MD

    The Peter Attia Drive

    8,623 Listeners

    The Journal. by The Wall Street Journal & Spotify Studios

    The Journal.

    6,060 Listeners

    Huberman Lab by Scicomm Media

    Huberman Lab

    29,124 Listeners

    Biotech Hangout by Daphne Zohar, Josh Schimmer, Brad Loncar, Tim Opler & more

    Biotech Hangout

    19 Listeners

    The Rest Is Politics by Goalhanger

    The Rest Is Politics

    3,096 Listeners

    DER TRUMP EFFEKT  –  ZDF auslandsjournal – Der Podcast by ZDF

    DER TRUMP EFFEKT – ZDF auslandsjournal – Der Podcast

    10 Listeners

    Die Peter Thiel Story by Deutschlandfunk

    Die Peter Thiel Story

    27 Listeners