It's a meandering world of comedy when Joel McHale joins Rob Lowe. On today's episode you'll find out about the evolution of Talk Soup, the obstacles Joel has faced with his Dyslexia, how The White House correspondents dinner rewired his nerves, and the joke that hurt Robert De Niro's feelings! Got a question for Rob? Call our voicemail at (323) 570-4551. Yours could get featured on the show!

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