We are very excited to bring you our new series on Landmark Papers in Vascular Surgery! 

We are proud to start off with the IMPROVE trial, and for that we welcome Professor Janet Powell, Professor of Vascular Biology & Medicine at Imperial College, London and Chief Investigator of the IMPROVE Trial. 

Professor Powell studied medicine in the USA (after obtaining a PhD in Biophysics in London), before returning to Britain where she completed clinical training in pathology, specialising in cardiovascular risk. Initially her research interests were confined to the laboratory but soon extended from bench (vascular biology) to bedside (clinical trials). She has been integral to all of the key UK trials in abdominal aortic aneurysm management, including the UK Small Aneurysms Trial, the EVAR-1 and EVAR-2 trials and of course, the IMPROVE Trial.  In recognition of her outstanding contribution to research in vascular surgery, she was recipient of the Lifetime Achievement Award at the Vascular Society of Great Britain and Ireland Annual Scientific Meeting in 2012, and is honoured with a named lectureship at the annual European Society of Vascular Surgery conference, called the Janet Powell Lecture in Evidence-Based Vascular Surgery.  

The IMPROVE Trial is the “Immediate Management of Patients with Rupture: Open Versus Endovascular Repair,” originally published in the British Medical Journal in 2014. Below are links to the original manuscript as well as several additional related publications:

• Original Manuscript 
• One-Year Outcomes 
• Three-Year Outcomes 
• Observations Regarding Clinical Care (2014)
• Re-intervention Data (2018)

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