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Lead: Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries
Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries
The American Journal of Psychiatry
Quantifying the contribution of environmental and genetic factors to alcohol use disorder (AUD) criterion count across different ancestries may provide insight into the biopsychosocial etiology of AUD. Although polygenic risk prediction represents an important future application, its utility may be enhanced when considered in the context of environmental predictors. The authors used large African- and European-ancestry samples to examine how genetic, psychiatric, and environmental factors predict AUD criterion count. In both African and European ancestry groups, environmental factors explained the majority of the variance in AUD criterion count, but polygenic risk was also a statistically significant predictor. These findings may help inform clinical, research, and policy efforts to mitigate AUD risk.
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By American Society of Addiction Medicine
4.9
77 ratings
Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries
The American Journal of Psychiatry
Quantifying the contribution of environmental and genetic factors to alcohol use disorder (AUD) criterion count across different ancestries may provide insight into the biopsychosocial etiology of AUD. Although polygenic risk prediction represents an important future application, its utility may be enhanced when considered in the context of environmental predictors. The authors used large African- and European-ancestry samples to examine how genetic, psychiatric, and environmental factors predict AUD criterion count. In both African and European ancestry groups, environmental factors explained the majority of the variance in AUD criterion count, but polygenic risk was also a statistically significant predictor. These findings may help inform clinical, research, and policy efforts to mitigate AUD risk.
Read this issue of the ASAM Weekly
Subscribe to the ASAM Weekly
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