Initially recognized as a poison in blood sausage by a German country doctor in the 19th century CE, botulinum toxin was isolated and purified during world war II by the American military. It was ophthalmogist Dr. Alan Scott who recognized the clinical utility of the toxin, which now has over 150 different applications!

In this episode, we will trace the history of attempts at transplanting cells, tissues, and organs from animals into humans. From world-famous surgeons to medical charlatans, all manner of people have tried, and all inevitably failed. However, with the rise of genetic editing, there is new hope that xenotransplantation will turn from a dream into reality!

In this episode, we return to a previous series, looking at the history of different organs in the body. The history of our understanding of the spleen, including its function, will be covered, as well as the development of surgery on the spleen. And in another instalment of Suture Tales, we'll meet Quincy Gardner Colton, a medical school dropout, showman, and integral figure in the history of nitrous oxide as an anesthetic.

In this bonus suture tale episode, we cover the life and works of the famous Italian surgeon and anatomist Antonio Scarpa. While many are familiar with him from the eponymously named fascia, his contributions to the science of medicine extend well beyond this. Known as a tyrant in life, a number of anatomical structures were removed after his death, including his head, which can still be seen today! And as an extra bonus, the life of his mentor, Giovanni Morgagni is also explored.

In this episode, we cover the legendary figure of Hua T'o, the best known (and one of the few) surgeons from Ancient China, as well as the state of surgical treatments at the time. The tale of his most famous operation, on the General Guan Yu, is also examined. Finally, the role of culture and religion on the development of anatomical and surgical knowledge in Ancient China is explored.

In this episode, we'll take a look at some of the contributions he made in surgery and anatomy, as well as some of the errors of his that were repeated for centuries before being disproven. We'll also have a look at the history of the first known surgery, trephination (or drilling a hole in the head), the origins of the word 'cancer', and lots more! As well, Suture Tales takes a look at a giant in the history of ENT surgery, Dr. John Conley. And if you stay to the end, there's even some poetry!

In the 100th episode of Legends of Surgery, we will explore the life of one of medicine and surgery's greatest influences: the Greek physician from Ancient Rome, Claudius Galen. The events of his life will be covered, as well as some of the amazing feats he performed. In the second part of this mini-series, Galen's lasting impact on anatomy and surgery will we outlined.

This episode also features a Suture Tale, this time on the surgeon and anatomist Carl Toldt, who described the important surgical landmark we now know as the white line of Toldt!

In this episode, we'll cover the history of transgender medicine, with a focus on the development of the main surgical procedures in gender reassignment surgery, including vaginoplasty, phalloplasty, and metoidioplasty. A number of trailblazing surgeons and patients will be covered, and there is even a suture tale about a strange Victorian practice of clitoridectomy. Listener beware: this episode contains some graphic descriptions of genital surgery.

In this episode, we're going to do something a bit different. I've taken a number of shorter but very interesting topics, either that I've come across on my own or have been suggested by listeners, and turned 5 of them into this episode. There's a medication, a maneuver, a procedure, a person, and a device! And if you have an idea for a topic, please let me know, maybe it will be on the next suture tales!