By Aastha Jain
The podcast currently has 37 episodes available.
Denis Noble and Michael Levin - two great minds in biology come together on Live Longer World.
The gene-centric view has failed us in advancing progress on many diseases, and we need to now take a systems based approach focused on functional networks within biological systems.
Michael Levin is an American developmental and synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. His research is focused on bioelectricity and he is my co-host for this podcast.
0:10 Denis’s journey to systems biology; cell voltage is a global property of the cell
3:45 Advice to young researchers pursuing systems biology
7:00 “Absolutely everything is wrong with Neo-Darwinism”
14:10 Epigenetic inheritance
19:12 Genetic vs. other information used by organisms
23:48 Biology textbooks have to expand beyond DNA in 50 years
25:03 Epigenetic processes are ubiquitous
28:58 If not DNA, what is the blueprint of life
36:15 Rewriting biology textbooks is fundamental
39:57 “A lot of time has been wasted” (in biology)
46:52 Darwin on the “Origin of Species”
55:38 “Unfortunate that Philosophy and science have diverged”
1:00:31 Importance of Functional networks; DNA does not predict disease
This interview is part of my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity.
Instagram: https://www.instagram.com/aasthajs/
Dr. Alfonso Martinez Arias is a development biologist and the author of the book The Master Builder: How the New Science of the Cell Is Rewriting the Story of Life. He also co-authored the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize.
Towards the end, we also talk about Alfonso's fascinating work on gastruloids which are a model to unravel the mysteries of embryonic development, and understand how humans are formed.
Episode Show Notes: https://livelongerworld.com/p/aarias
The following is a fascinating interview with Dr. Charley Lineweaver, who worked with Paul Davies on his work on cancer which we discuss. Episode Show Notes: https://livelongerworld.com/p/clineweaver
Instagram: https://www.instagram.com/aasthajs/
- Targeting cancer's weaknesses, not its strengths: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282648/
This is the third in my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity.
0:38 Ken’s background - From physics to bioelectricity
6:10 Bioelectricity in the era of the “genetic code”
10:27 Ken’s first experiments in ion movement using light
23:25 Proton pump and its significance
26:07 Neurons respond to electrical signals
36:26 Working in Lionel Jaffe’s lab
47:39 Mike Levin as an undergrad
48:49 Membrane potential left-right asymmetry in cells
52:59 Epithelia is powerfully electrogenic
57:49 Advances for bioelectricity
59:27 Underrated people in the field
This is the second of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Min Zhao's work is focused on the role of ion currents and applied electric fields in cell migration and wound repair.
Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more.
This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity.
Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer.
Find me: https://twitter.com/aasthajs
Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin.
Episode Show Notes: https://livelongerworld.com/p/msekeres
Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314
Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.
Episode Show Notes: https://livelongerworld.com/p/jgarrison
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The podcast currently has 37 episodes available.