Live Longer World

Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.  In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more.   

If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you. 

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium  

Support on Patreon: https://www.patreon.com/livelongerworld 

One-Time support: https://www.paypal.com/paypalme/livelongerworld  

ETHAN WEISS LINKS: 

Website: https://profiles.ucsf.edu/ethan.weiss 

Twitter: https://twitter.com/ethanjweiss  

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/ 

Twitter: https://twitter.com/livelongerworld 

Newsletter: https://livelongerworld.substack.com/ 

Instagram: https://www.instagram.com/longevityfuture/ 

Patreon: https://www.patreon.com/livelongerworld 

YouTube: https://www.youtube.com/c/LiveLongerWorld 

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS: 

0:00 Welcome to Live Longer World 

0:44 Misconceptions of heart disease / young people with heart disease 

4:01 Predictors of heart disease 

6:59 LDL vs HDL; Triglycerides 

12:51 Small-dense LDL vs. Large fluffy LDL 

16:09 Dietary Carbohydrates & heart disease risk 

25:50 Inflammation & Cardiovascular risk 

26:43 Lipoproteins, ApoB, Lp(a) 

31:31 Statins, PCSK9 inhibitors 

32:45 ApoB as gold standard risk marker 

36:50 Triglycerides & Insulin resistance 

40:00 Saturated Fat 

42:42 Variation in Cholesterol measurement 

46:03 Body composition as marker for heart disease risk 

51:23 Ketogenic diets & heart health 

56:43 Keyto breath sensor 

1:01:46 Stress & heart disease 

1:04:44 Growth hormone & heart disease 

1:07:46 On the shortness of life 

1:10:52 Support & Connect with 

Live Longer World  Episode Show Notes: https://livelongerworld.substack.com/p/eweiss

 Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. 

Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.

Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology.  

His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging.  

Michael Levin’s work is fascinating and will surely leave you thinking. I hope you enjoy the conversation!   

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

MICHAEL LEVIN LINKS: 

Website: https://ase.tufts.edu/biology/labs/levin/

Twitter: https://twitter.com/drmichaellevin 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/

Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium 

TIMESTAMPS: 

0:40 How do cells decide what to build? 

10:05 DNA is insufficient for dictating collective intelligence of cells 

19:00 Anatomical Complier (End game) 

22:24 History of Cellular Collective Intelligence & Ala Turing 

26:30 Regenerative Medicine & Morphoceuticals 

38:05 Cells forming new anatomies 

44:53 Cancer as a morphogenetic problem 

55:16 David Sinclair, Bioelectrics to reverse aging 

57:44 Synthetic Wombs & Artificial Life 

59:41 Support Live Longer World!

Episode Show Notes: https://livelongerworld.substack.com/p/mlevin 

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts. 

And if you are further inclined to show love and support, you can donate on Patreon: patreon.com/livelongerworld

Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.  

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.  

In today’s episode, you will learn: 

- The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin 

- 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril 

- Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin 

- Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more 

- Richard’s thoughts on lifespan vs. healthspan  

All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

RICHARD MILLER LINKS: 

Website: http://www.richmillerlab.com/

Photography: https://richardmiller.zenfolio.com/

Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS: 

0:55 Richard Miller Intro 

1:51 Richard Miller Wildlife photography 

3:30 ITP - the gold standard for testing longevity drugs & winning drugs 

10:51 Rapamycin, Rapamycin + Acarbose 

18:48 Rapamycin + Acarbose Dosing Schedule 

20:15 Combination of drugs, Rapamycin + Metformin 

21:56 17-Alpha Estradiol 

25:45 Canagaflozin 

31:34 Does Richard take the 4 winning drugs? 

32:46 3 Drugs that have small lifespan effects & promising 

36:30 GPLD-1 & shared mechanisms in longevity drugs 

44:04 Resveratrol in ITP 

46:27 NR, NMN 

52:34 Curcumin, Green Tea Extract, MCT Oil 

54:54 Fisetin & Senolytics 

56:12 Why most published research findings are false 

1:00:03 Healthspan biomarkers at the ITP 

1:02:38 Can you have healthspan without lifespan? 

1:07:37 Fish Oil, Spermidine, Sulforophane 

1:12:13 Unpublished data Richard is excited about 

1:17:47 Flying Pigs & Aubrey De Grey 

1:20:00 Exponential rise in aging research

Episode Show Notes: https://livelongerworld.substack.com/p/rmiller

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

Aging is universal. Let's unite in this fight.

Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.   

Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today’s episode!  

As a last point to Yuri’s introduction, because I’d be remiss if I didn’t mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth.  

In today’s episode, you will learn: 

- The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair’s theory The Weak Epigenetic Theory of Aging) 

- Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state  

- What is it and what are the open questions in the field 

- What are the cancer risks associated with it 

- Why Yuri believes in Cryonics 

- Why Yuri got interested in uncovering the COVID-19 Lab Leak theory  

- Pharma in Russia

If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin  

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium  

Support on Patreon: https://www.patreon.com/livelongerworld 

One-Time support: https://www.paypal.com/paypalme/livelongerworld

YURI DEIGIN LINKS: 

Twitter: https://twitter.com/ydeigin

LinkedIn: https://www.linkedin.com/in/yurideigin/

Medium: https://yurideigin.medium.com/

YouthBio Therapeutics: https://youthbiotx.com/ 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS: 

00:00 "We're not crazy" 

0:37 100% life extension & translation to humans 

4:28 Aging is potentially an engineering problem 

12:45 Strong Epigenetic Theory of Aging 

19:26 Epigenetic Reprogramming 

29:00 Risk of Cancer with Epigenetic reprogramming 

33:00 Rejuvenation without cancer risk? 

38:30 Why Cryonics Makes Sense 

48:00 COVID Lab Leak Theory 

53:45 Pharma in Russia 

58:40 Optimism in Longevity 

1:00:50 Aging is Universal. Let's Unite in this Fight

Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.

Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation.

If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast

Sign up for Premium Subscriber

Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium

Support on Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld

PETER ADAMS LINKS:

Lab Website & Bio: http://www.padamslab.org/pages/members.html

Peter Adams Twitter: https://twitter.com/AdamsBioAging

Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd

LIVE LONGER WORLD LINKS:

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams 

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease. 

In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinson’s. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company.   

Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

ANDY LEE / VINCERE BIO LINKS: 

Vincere Website: https://vincerebio.com/

Andy Lee Twitter: https://twitter.com/andy_d_lee

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon page: https://www.patreon.com/livelongerworld

Podcast All Platforms: https://anchor.fm/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Apple Podcasts: https://apple.co/3eZAoAp

Spotify: https://spoti.fi/3eZB6O5

Google Podcasts: https://bit.ly/3HN0keG

Premium Subscriber Benefits: https://www.livelongerworld.com/premium

TIMESTAMPS: 

0:00 Live Longer World Intro 

0:34 Andy Lee & Vincere Bio Intro 

1:55 Vincere & the connection between mitochondria & Parkinson's 

7:39 Mitophagy & Parkinson’s disease 

16:29 Role of USP30 in Mitochondria & Parkinson’s 

22:26 Vincere small molecules testing 

25:18 Other pathways affected during Parkinson's 

30:53 Computation Biology Platform used by Vincere 

36:50 Urolithin A & Coq10 to help with Parkinson’s 

39:45 Biomarkers for Mitophagy 

42:46 Too much mitophagy? 

44:50 Challenges running a biotech company 

48:19 Path forward for Vincere 

49:36 Support, share and follow Live Longer World!

Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science!   

Key points summarized in the show notes for premium subscribers include: 

1. The connection between Mitochondrial quality control & Parkinson’s disease 

2. Mitophagy and the science behind targeting the mitochondria 

3. Overview of the Biological Simulation Platform used by Vincere Bio 

4. Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinson’s 

5. Challenges with running a Biotech Co.

Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium

Ep. Show notes: https://livelongerworld.substack.com/p/alee

My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA damage. 

A lot of us have heard about the link between DNA damage and aging and this conversation really dives into it.  

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bschumacher 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

DR. BJORN SCHUMACHER LINKS: 

Lab Website: https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher

Twitter: https://twitter.com/schumacherbj

Author of the book: The Mysteries of Human Aging: Surprising Insights from a Science That's Still Young: https://amzn.to/3LyR3JU

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon page: https://www.patreon.com/livelongerworld

Podcast All Platforms: https://anchor.fm/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Apple Podcasts: https://apple.co/3eZAoAp

Spotify: https://spoti.fi/3eZB6O5

Google Podcasts: https://bit.ly/3HN0keG

Premium Subscriber Benefits: https://www.livelongerworld.com/premium

TIMESTAMPS: 

0:00 Live Longer World Intro 

0:30 Bjorn Schumacher Intro 

1:22 DNA Damage as Central to the Aging process 

3:37 DNA repair with age 

8:39 Premature aging; 2 distinct forms of DNA damage 

14:15 How does an aging human survive with DNA damage & tamp down cancer? 

18:20 Stress to reproductive cells builds up immunity in the body 

24:41 Female reproduction, Menopause & DNA repair 

27:46 p53 and it’s role in DNA repair 

35:13 BiT Clock: New Biological Age Clock 

43:59 Skin Aging and DNA damage 

48:06 Stress in the intestine / gut can alter the chromosome 

53:00 Germ cells are immortal

For links to DR. Bjorn Schumacher research discussed: https://livelongerworld.substack.com/p/bschumacher

Want Summarized Notes on Key Points Discussed in the Podcast? 

Gain access by signing up as a premium subscriber. Your contribution supports my work the advancement of longevity science!

Key points summarized in the show notes for premium subscribers include:

Learn more: https://www.livelongerworld.com/premium

My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the cause of aging, but the programmatic theory of aging shows that that might not be the case. We also discussed his critique of the hallmarks of aging and how there should be a better paradigm for the aging field. Lastly, we also discussed how research from his lab on C. Elegans might explain some of the conflict around whether sirtuins affect lifespan and how C. Elegans also show versions of this programmatic theory of aging, which can give us a better understanding of how to study aging.

Note: There is a point in the conversation (40:41) where David pulls up some slides to better explain the Multifactorial Model of Aging. So if you are listening to the audio version, you might want to refer to YouTube or the show notes.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/dgems 

Support on Patreon: https://www.patreon.com/livelongerworld  

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

DR. DAVID GEMS LINKS: 

Lab Website: https://www.ucl.ac.uk/~ucbtdag/DGHistory.html 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon page: https://www.patreon.com/livelongerworld

Podcast All Platforms: https://anchor.fm/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Apple Podcasts: https://apple.co/3eZAoAp

Spotify: https://spoti.fi/3eZB6O5

Google Podcasts: https://bit.ly/3HN0keG

Premium Subscriber Benefits: https://www.livelongerworld.com/premium

TIMESTAMPS: 

00:00 Live Longer World 

00:25 David Gems Intro 

1:47 History of the theories of aging 

12:23 Hyperfunction / Programmatic Theory of Aging 

24:57 Programmatic Theory of Aging in C. Elegans 

36:59 Hyperfunction theory of Aging in Humans 

40:41 Multifactorial Model of Aging 50:32 Mutation in C. Elegans affecting Sirtuin research? 

59:57 Sirtuin research in humans & conflicting sirtuin research 

1:04:44 Metformin affects the gut microbiome 

1:07:41 Critique of the Hallmarks of Aging 

1:16:12 Disruption in Early Life could lead to Aging related diseases 

1:24:23 Support, share, and follow Live Longer World

To find links to David Gems research discussed, please refer to the show notes: https://livelongerworld.substack.com/p/dgems 

Thanks for listening & if you enjoy the episode, please leave a review on Apple podcasts, support on Patreon, subscribe & share!  

Stay in good health - Aastha.

My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas!   

Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage.   

Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8).  

I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people.   

This is a shorter episode and I hope you learn more about the importance of micronutrients!  

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames  

RELATED WRITING: 

My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames 

My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods  

Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Find me on Twitter: https://twitter.com/livelongerworld

Support on Patreon: https://www.patreon.com/livelongerworld 

DR. BRUCE AMES LINKS: 

Website: http://www.bruceames.org/ 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon page: https://www.patreon.com/livelongerworld

Podcast All Platforms: https://anchor.fm/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Apple Podcasts: https://apple.co/3eZAoAp

Spotify: https://spoti.fi/3eZB6O5

Google Podcasts: https://bit.ly/3HN0keG

Premium Subscriber Benefits: https://www.livelongerworld.com/premium 

TIMESTAMPS: 

00:00 Live Longer World 

00:36 Bruce Ames Intro 

1:50 Micronutrient triage theory 

5:40 Micronutrient deficiencies & age acceleration 

9:10 Vitamin D for healthy aging 

12:26 CHORI Bar 

14:46 Measuring micronutrients (blood finger-prick) 

16:55 Bruce Ames diet 

18:19 Asthma caused by obesity / bad diet improved by CHORI bar 

21:21 Dr. Ames lifestyle over the years 

22:47 Importance of zinc 

24:15 Nutrition is complicated 

24:44 Dr. Ames last words & advice for young scientists

Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.

My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research.  Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity. 

In today's discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.  

All platforms / Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/bkennedy 

Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Support on Patreon: https://www.patreon.com/livelongerworld 

DR. BRIAN KENNEDY LINKS: 

Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/

Twitter: https://twitter.com/BKennedy_aging 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

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DR. BRIAN KENNEDY RESEARCH DISCUSSED: 

2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/ 

2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/ 

2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/ 

2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/ 

2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/ 

2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081

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