Live Longer World

Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more.

This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity.

Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer.

Find me: https://twitter.com/aasthajs

Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin.

Episode Show Notes: https://livelongerworld.com/p/msekeres

Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314

Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.

Episode Show Notes: https://livelongerworld.com/p/jgarrison

TIMESTAMPS:

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.

Aging is universal. Let's unite in this fight.

Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity.

Episode Show Notes: https://livelongerworld.substack.com/p/gwest

Find me (Aastha) on Twitter: https://twitter.com/aasthajs

DR. GEOFFREY WEST LINKS:

Newsletter: https://livelongerworld.substack.com/

Twitter: ⁠https://twitter.com/aasthajs

Instagram: https://www.instagram.com/aasthajs/

Airchat: https://www.getairchat.com/aasthajs

TIMESTAMPS:

32:33 Upper limit to human age?

39:08 Quantifying Caloric restriction

41:52 Metabolism & Body temperature

49:05 Scaling laws in age-related damage

56:35 Scaling body sizes across species

1:01:38 Scaling laws in drug dosage (LSD & Elephants)

1:11:06 Drug dosage in children (Tylenol & babies)

1:13:44 Vaccine dosage scaling laws

1:17:51 Sleep & Aging in different organisms

1:31:22 Early stimulation for child development

1:36:35 Fasting, meal frequency & digestive time

1:39:10 Sleep demands with work & physical activity

1:43:40: Scaling laws in cities, companies & universities

2:02:00 Outro

POPULAR EPSIODES:

Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.

All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad 

Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!   

There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.   

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ 

Find me (Aastha) on Twitter: https://twitter.com/aasthajz 

DR. STEVEN AUSTAD LINKS: 

Website: https://www.stevenaustad.com/

Twitter: https://twitter.com/StevenAustad

Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad 

CONNECT WITH AASTHA, LIVE LONGER WORLD: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/aasthajz

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/aasthajz/ 

TIMESTAMPS: 

0:00 Training lions 

7:15 Learning from Long-lived species 

9:55 Bowhead whales live 200 years 

12:55 House sparrows & longevity 

14:40 Study "successful" animals 

18:10 Naked Mole Rats 

20:45 What do bowhead whales die from? 

26:05 Why do ocean animals live longest? 

31:05 Beyond Caloric Restriction 

36:00 Intermittent Fasting & Circadian Rhythm 

42:40 Caloric Restriction for Healthy people? 

46:24 Will coffee shorten your life? 

49:43 The Blue Zone Myth 

55:50 Young Blood, I can't get you of out my Mind 

1:00:26 Hormones & Health (Growth Hormones for longevity?) 

1:05:18 Sex differences in longevity 

Episode Show Notes: https://livelongerworld.substack.com/p/saustad 

POPULAR EPSIODES: 

- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo 

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  Aging is universal. Let's unite in this fight. Stay in good health - Aastha.  

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2

Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.  

This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode!

Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

Find me (Aastha) on Twitter: https://twitter.com/aasthajz

SUPPORT LIVE LONGER WORLD:

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld

DOM D'AGOSTINO LINKS:

KetoNutrition: https://ketonutrition.org/

Website: https://linktr.ee/Domdagostino

Twitter: https://twitter.com/DominicDAgosti2

CONNECT WITH AASTHA, LIVE LONGER WORLD:

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/aasthajz

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/aasthajz/

TIMESTAMPS:

0:00 Ketogenic diet for muscle performance 

0:50 Dom’s supplements & modified keto diet 

3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom 

9:30 LDL, Triglycerides, Fatty Foods & Keto diet 

14:15 Dom’s routine & supplements 

18:09 Melatonin benefits for anti-cancer & antioxidant 

22:37 Ketogenic diet for women 

30:55 Ketogenic diet for children 

32:48 Genetic aspect to keto diet? 

38:32 Metformin for suppressing cancer 

46:30 Ketogenic diet & Alzheimer’s  

54:40 Exercise for mental health 

55:53 Keto for exercise performance & bodybuilding 

59:32 Endogenous metabolite & psychedelics 

1:09:05 Connect with me (Aastha)

Episode Show Notes: https://livelongerworld.substack.com/p/dom2

Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts.

Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 

Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. 

This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode!  

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ 

Find me (Aastha) on Twitter: https://twitter.com/livelongerworld 

SUPPORT LIVE LONGER WORLD: 

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

DOM D'AGOSTINO LINKS: 

KetoNutrition: https://ketonutrition.org/

Website: https://linktr.ee/Domdagostino

Twitter: https://twitter.com/DominicDAgosti2

CONNECT WITH AASTHA, LIVE LONGER WORLD: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

TIMESTAMPS: 

0:00 Ketogenic diet is not optimal for everyone 

0:56 Dom D’Agostino Intro 

1:29 Plant-based ketogenic diet 

3:20 Ketogenic diet & brain protection against seizures 

16:40 Ketone Esters & Salts 

19:29 Does the brain need glucose? 

21:37 Intermittent Ketosis & Fasting Mimicking Diet 

25:17 Cyclic Ketogenic diet for longevity 

28:40 Devices for tracking ketosis 

30:30 Ketogenic diet for longevity vs. Caloric restriction 

37:50 Keto diet for cancer prevention 

41:57 Keto diet, Insulin pathway, and glucose 

46:50 Time restricted eating benefits 

50:17 Dom vs. Layne Norton on Joe Rogan podcast 

51:40 Muscle for longevity (especially for women) 

56:10 Support Live Longer World

Episode Show Notes: https://livelongerworld.substack.com/p/dom1

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  

Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple

Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. 

Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.

It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!  

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

Find me (Aastha) on Twitter: https://twitter.com/livelongerworld 

SUPPORT LIVE LONGER WORLD: 

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

SAM APPLE LINKS: 

Ravenous book: https://amzn.to/3yT9qpd

Website: http://www.samapple.com/

Twitter: https://twitter.com/Sam_Apple1

CONNECT WITH AASTHA, LIVE LONGER WORLD: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

TIMESTAMPS: 

0:00 Cancer as a disease of modern societies 

1:27 Otto Warburg & the Cancer-Metabolic Connection 

2:27 Warburg’s research on respiration 

4:02 Why was cancer skyrocketing in Western societies? 

9:17 Warburg Effect: Warburg’s research on cancer cells 

15:00 Why do cancer cells take up so much glucose? 

17:44 Cancer-Diet Connection 

21:44 Cancer, Ketogenic diets & Fasting 

23:43 Hibernation of the metabolic story of cancer 

27:20 Hitler’s connection with cancer 

30:07 Warburg’s arrogance 

31:51 Why does cancer need glucose? 

38:46 Warburg’s stigma: connecting with Nazi’s 

40:51 Is insulin responsible for cancer? 

48:00 Science is not immune from politics 

50:24 Prostate cancer & obesity 

52:13 Pendulum swing in cancer research 

54:40 Mitochondria & Cancer Connection 

57:07 Nazi’s fixation on cancer

Episode Show Notes: https://livelongerworld.substack.com/p/sapple 

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. 

You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.

Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab.  We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.   

Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.  

It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!  

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld

Find me on Twitter: https://twitter.com/livelongerworld 

VADIM GLADYSHEV LINKS: 

Website: https://gladyshevlab.bwh.harvard.edu/2022 

Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium 

TIMESTAMPS: 

0:00 Vadim Gladyshev Intro 

1:28 Live Longer World 

2:17 Selenium’s dual role in aging (the good, the bad, the ugly) 

11:27 Antagonistic Pleiotropy 

13:53 Selenium & Cancer 

15:58 Selenium Dosage (don’t get too much!) 

18:30 Reactive Oxygen Species, Antioxidants & Aging 

22:30 Fundamental basis of Aging 

24:09 Aging is damage 

29:20 Single cell Epigenetic Clocks 

34:22 Aging in the Womb 

42:16 Parent’s lifestyle for aging in embryo 

44:14 Rapamycin during development 

49:06 Other compounds 

51:53 Slowing Aging vs. Rejuvenation 

56:08 New projects being worked on 

57:17 Confidence level in extending lifespan within 30 years 

59:17 Support Live Longer World  

Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.

Aging is universal. Let's unite in this fight. Stay in good health - Aastha.