This interview is part of my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity.

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Dr. Alfonso Martinez Arias is a development biologist and the author of the book The Master Builder: How the New Science of the Cell Is Rewriting the Story of Life. He also co-authored the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize.

Towards the end, we also talk about Alfonso's fascinating work on gastruloids which are a model to unravel the mysteries of embryonic development, and understand how humans are formed.

Episode Show Notes: https://livelongerworld.com/p/aarias

The following is a fascinating interview with Dr. Charley Lineweaver, who worked with Paul Davies on his work on cancer which we discuss. Episode Show Notes: https://livelongerworld.com/p/clineweaver

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- Targeting cancer's weaknesses, not its strengths: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282648/

This is the third in my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity.

0:38 Ken’s background - From physics to bioelectricity

6:10 Bioelectricity in the era of the “genetic code”

10:27 Ken’s first experiments in ion movement using light

23:25 Proton pump and its significance

26:07 Neurons respond to electrical signals

36:26 Working in Lionel Jaffe’s lab

47:39 Mike Levin as an undergrad

48:49 Membrane potential left-right asymmetry in cells

52:59 Epithelia is powerfully electrogenic

57:49 Advances for bioelectricity

59:27 Underrated people in the field

This is the second of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Min Zhao's work is focused on the role of ion currents and applied electric fields in cell migration and wound repair.

Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more.

This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity.

Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer.

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Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin.

Episode Show Notes: https://livelongerworld.com/p/msekeres

Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314

Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.

Episode Show Notes: https://livelongerworld.com/p/jgarrison

TIMESTAMPS:

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.

Aging is universal. Let's unite in this fight.

Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity.

Episode Show Notes: https://livelongerworld.substack.com/p/gwest

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DR. GEOFFREY WEST LINKS:

Newsletter: https://livelongerworld.substack.com/

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TIMESTAMPS:

32:33 Upper limit to human age?

39:08 Quantifying Caloric restriction

41:52 Metabolism & Body temperature

49:05 Scaling laws in age-related damage

56:35 Scaling body sizes across species

1:01:38 Scaling laws in drug dosage (LSD & Elephants)

1:11:06 Drug dosage in children (Tylenol & babies)

1:13:44 Vaccine dosage scaling laws

1:17:51 Sleep & Aging in different organisms

1:31:22 Early stimulation for child development

1:36:35 Fasting, meal frequency & digestive time

1:39:10 Sleep demands with work & physical activity

1:43:40: Scaling laws in cities, companies & universities

2:02:00 Outro

POPULAR EPSIODES:

Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.