LessWrong (30+ Karma)

“Lurking in the Noise” by J Bostock


Listen Later

The Dead Biologist

Suppose you're a biologist working with a bacterium. It's a nasty little bug, so you want to make sure your disinfecting protocol is effective. You have a rather good model of how the bacterium works, and it goes like this:

  • The bacterium contains DNA, which is like a master copy of the instructions as to how it works
  • This DNA is transcribed to RNA, which are little working copies of parts of the instructions and are disseminated throughout the bacterium
  • This RNA is translated into proteins, which actually do the stuff that makes the bacterium function

Yes, there are a few special cases where RNA actually does something, and your model seems to be missing some things---for one, the amount of protein produced from each RNA molecule seems to vary, and you can only account for about 90% of this variance; the other 10% appears [...]

---

Outline:

(00:09) The Dead Biologist

(01:33) The Thing in the Noise

(03:29) Heavy Pressure

(04:30) Almost-All is not All

(05:42) The Most Forbidden Technique

(06:40) Beyond Imperfect Models

(07:41) Coda

The original text contained 3 footnotes which were omitted from this narration.

---

First published:

June 25th, 2025

Source:

https://www.lesswrong.com/posts/gk3wj6mNWMACQDdZQ/lurking-in-the-noise

---

Narrated by TYPE III AUDIO.

...more
View all episodesView all episodes
Download on the App Store

LessWrong (30+ Karma)By LessWrong


More shows like LessWrong (30+ Karma)

View all
Making Sense with Sam Harris by Sam Harris

Making Sense with Sam Harris

26,469 Listeners

Conversations with Tyler by Mercatus Center at George Mason University

Conversations with Tyler

2,395 Listeners

The Peter Attia Drive by Peter Attia, MD

The Peter Attia Drive

7,953 Listeners

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas by Sean Carroll | Wondery

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

4,142 Listeners

ManifoldOne by Steve Hsu

ManifoldOne

89 Listeners

Your Undivided Attention by Tristan Harris and Aza Raskin, The Center for Humane Technology

Your Undivided Attention

1,472 Listeners

All-In with Chamath, Jason, Sacks & Friedberg by All-In Podcast, LLC

All-In with Chamath, Jason, Sacks & Friedberg

9,207 Listeners

Machine Learning Street Talk (MLST) by Machine Learning Street Talk (MLST)

Machine Learning Street Talk (MLST)

88 Listeners

Dwarkesh Podcast by Dwarkesh Patel

Dwarkesh Podcast

417 Listeners

Hard Fork by The New York Times

Hard Fork

5,461 Listeners

The Ezra Klein Show by New York Times Opinion

The Ezra Klein Show

15,321 Listeners

Moonshots with Peter Diamandis by PHD Ventures

Moonshots with Peter Diamandis

482 Listeners

No Priors: Artificial Intelligence | Technology | Startups by Conviction

No Priors: Artificial Intelligence | Technology | Startups

121 Listeners

Latent Space: The AI Engineer Podcast by swyx + Alessio

Latent Space: The AI Engineer Podcast

75 Listeners

BG2Pod with Brad Gerstner and Bill Gurley by BG2Pod

BG2Pod with Brad Gerstner and Bill Gurley

461 Listeners