Full article: https://www.ajronline.org/doi/abs/10.2214/AJR.20.23935 

Architectural distortion is a subtle but suspicious finding increasingly detected using digital breast tomosynthesis. Alicia Chen, MD discusses a timely meta-analysis by Dr. Choudhery and colleagues that found the pooled positive predictive value for AD without a known cause on DBT is 35%, the great majority of which represents invasive disease. This finding warrants tissue sampling.