In this episode of SurgOnc Today®, Sonia Orcutt, MD and Michail Mavros, MD, from the University of Arkansas for Medical Sciences are joined by Callisia N. Clarke, MD, MS, FACS, FSSO, Chief of the Division of Surgical Oncology at the Medical College of Wisconsin, and Alexandra Gangi, MD, FSSO, Director of the Gastrointestinal Tumor Program at Cedars Sinai Medical Center. The optimal treatment of high-grade well-differentiated neuroendocrine tumors has not been well-described, as they have only in recent years been identified as distinct from neuroendocrine carcinomas. The panelists discuss the most up-to-date information on diagnosis and management of gastroenteropancreatic high-grade well differentiated neuroendocrine tumors.