In this episode of Curbside Consults, we examine the 2022 revision of the clinical practice guideline on the management of hyperbilirubinemia in the newborn infant by the American Academy of Pediatrics (AAP). We are joined by two authors of the revised guideline: Dr. Alex R. Kemper, the Division Chief of Primary Care Pediatrics at Nationwide Children’s Hospital and Professor of Pediatrics at The Ohio State University College of Medicine; and Dr. Thomas Newman, Professor Emeritus of Epidemiology & Biostatistics and Pediatrics at UCSF.