This episode profiles the murder of 29-year-old Tonya Renee Lucas's six children, 12-year-old Antoine Lucas, 5-year-old Russell "Bookie" Williams, 3-year-old twins Takia Cook and Deon Cook, 2-year-old Gregory Cook, and 18-month-old Damien Cook who all died in an arson house fire in a rowhome in the 2400 block of East Eager Street, on July 7, 1992.

This episode also profiles the unsolved murder of 24-year-old Michael Lee Wise, who was shot and killed while trick or treating and pushing his young daughter in a stroller, on Halloween, October 31, 2019, in the 400 block of Gatewood Court in Glen Burnie.

This episode profiles the murder of 32-year-old Michael Pryor, who was stabbed to death on May 15, 2010, because he was due to testify in court about witnessing the murder of his friend, Nelson Gause.

This episode also profiles the unsolved murder of 32-year-old Joanne "Jody" Elizabeth LeCornu, who was shot to death in her vehicle in the parking lot of the Drum Castle Shopping Center in the 6400 block of York Road on March 2, 1996.

This episode profiles the senseless murder of my high school friend, 17-year-old Tiffany Chisolm, who was shot and killed on August 30, 1990, at her home in Reisterstown Maryland. Tiffany's mother was also shot but survived the shooting.

This episode also profiles the unsolved homicide of 19-year-old Roger Hearne Kelso, who was reported missing by his family in 1963. Roger's remains were later found by construction crews in a metal dumpster on April 23, 1985, on the construction site of Marley Station Mall in Glen Burnie, but Roger was not positively identified until 2019.

This episode profiles the murder of federal informant 29-year-old Kareem Kelly Gwest who was shot by 31-year-old Antonio Hall on September 20, 2009, in the 2400 block of Huron Court in Westport.

This episode also profiles the senseless, unsolved murder of 13-year-old Jayz Agnew who was shot on November 8, 2022, while raking leaves in the front yard of his home, in the 2100 block of Jameson Street in the Hillcrest Heights area of Temple Hills in Prince George's County.

This episode profiles the murder of 27-year-old Scott Edward Shipley, who was murdered by his wife 32-year-old Melissa Lynn Baumgardner Shipley and her boyfriend, 29-year-old Butchie Stemple Jr. on November 15, 2002, in Carroll County Maryland.

This episode also profiles the 51-year-old unsolved homicide of 25-year-old Charles Edward Crusoe, who was found murdered in a wooded area off of Bayside Beacks Road in Pasadena Maryland on February 4, 1974. Charles had been a former musician with the 70's group, The Ohio Players.

This season 12 premier episode profiles the senseless, brutal murder of 41-year-old Associate Pastor Latrina Ashburne, who was shot and killed on May 27, 2016, in the 2900 block of Rosalind Avenue. 31-year-old David Carter and 39-year-old Clifton Mosley were later found guilty of one count each of witness retaliation murder, witness tampering, and two counts of conspiracy to murder a witness.

This episode also profiles the unsolved homicide of nineteen- year-old Charles Turgot Jones, who was found murdered in a shallow grave on Maryland Route 648, near Mountain Road in Pasadena on November 10, 1978.

This episode profiles the murder of 28-year-old Timothy Caughman who was stabbed by 28-year-old James Harris Jackson with an 18-inch-long Roman sword in New York on March 19, 2017, because James wanted to start a race war.

This episode also profiles the unsolved murder of 33-year-old Janell Erlita Balogun who was found murdered lying in the woods on River Road in Oella on June 10, 2012.

This episode profiles the horrific rape and murder of 16-year-old Arnesha Bowers, who was murdered and set on fire by 20-year-old John Childs and 23-year-old Adonay Dixon, on June 7, 2015.

This episode also profiles the unsolved murder of 46-year-old Bryant Bagley who was found murdered in the street in the 200 block of Bolivar Avenue in Brooklyn on April 1, 2012.

This episode profiles the hate related murder of 23-year-old Army Lieutenant Richard Wilbur Collin lll, who was stabbed to death by 22-year old Sean Christopher Urbanski at a bus shuttle stop on the campus of the University of Maryland College Park, on May 20, 2017.

This episode also profiles the unsolved murder of 26-year-old Tamba Nyorkor who was found shot to death in his apartment in the 9700 block of Clock Tower Lane in Columbia, on October 8, 2008.

This episode profiles the murders of 14-year old Ariana Fumas Diaz and 21-year-old Daniel Alejandro Alvaredo Cuellar, who were brutally killed by members of the MS-13 gang during the Spring and Summer of 2019.

This episode also profiles the unsolved murder of 18-year-old Lamarst Alexander Porter, Jr. who was kidnapped on September 17, 2003 in the 1700 block of Severn Tree Boulevard in Severn. Lamarst's body has never been found.