This episode profiles the murder of federal informant 29-year-old Kareem Kelly Gwest who was shot by 31-year-old Antonio Hall on September 20, 2009, in the 2400 block of Huron Court in Westport.

This episode also profiles the senseless, unsolved murder of 13-year-old Jayz Agnew who was shot on November 8, 2022, while raking leaves in the front yard of his home, in the 2100 block of Jameson Street in the Hillcrest Heights area of Temple Hills in Prince George's County.

This episode profiles the murder of 27-year-old Scott Edward Shipley, who was murdered by his wife 32-year-old Melissa Lynn Baumgardner Shipley and her boyfriend, 29-year-old Butchie Stemple Jr. on November 15, 2002, in Carroll County Maryland.

This episode also profiles the 51-year-old unsolved homicide of 25-year-old Charles Edward Crusoe, who was found murdered in a wooded area off of Bayside Beacks Road in Pasadena Maryland on February 4, 1974. Charles had been a former musician with the 70's group, The Ohio Players.

This season 12 premier episode profiles the senseless, brutal murder of 41-year-old Associate Pastor Latrina Ashburne, who was shot and killed on May 27, 2016, in the 2900 block of Rosalind Avenue. 31-year-old David Carter and 39-year-old Clifton Mosley were later found guilty of one count each of witness retaliation murder, witness tampering, and two counts of conspiracy to murder a witness.

This episode also profiles the unsolved homicide of nineteen- year-old Charles Turgot Jones, who was found murdered in a shallow grave on Maryland Route 648, near Mountain Road in Pasadena on November 10, 1978.

This episode profiles the murder of 28-year-old Timothy Caughman who was stabbed by 28-year-old James Harris Jackson with an 18-inch-long Roman sword in New York on March 19, 2017, because James wanted to start a race war.

This episode also profiles the unsolved murder of 33-year-old Janell Erlita Balogun who was found murdered lying in the woods on River Road in Oella on June 10, 2012.

This episode profiles the horrific rape and murder of 16-year-old Arnesha Bowers, who was murdered and set on fire by 20-year-old John Childs and 23-year-old Adonay Dixon, on June 7, 2015.

This episode also profiles the unsolved murder of 46-year-old Bryant Bagley who was found murdered in the street in the 200 block of Bolivar Avenue in Brooklyn on April 1, 2012.

This episode profiles the hate related murder of 23-year-old Army Lieutenant Richard Wilbur Collin lll, who was stabbed to death by 22-year old Sean Christopher Urbanski at a bus shuttle stop on the campus of the University of Maryland College Park, on May 20, 2017.

This episode also profiles the unsolved murder of 26-year-old Tamba Nyorkor who was found shot to death in his apartment in the 9700 block of Clock Tower Lane in Columbia, on October 8, 2008.

This episode profiles the murders of 14-year old Ariana Fumas Diaz and 21-year-old Daniel Alejandro Alvaredo Cuellar, who were brutally killed by members of the MS-13 gang during the Spring and Summer of 2019.

This episode also profiles the unsolved murder of 18-year-old Lamarst Alexander Porter, Jr. who was kidnapped on September 17, 2003 in the 1700 block of Severn Tree Boulevard in Severn. Lamarst's body has never been found.

This episode profiles the murder of 20-year-old Taya Ashton, who was murdered by 27-year old DeAllen Price on July 17, 2021. Taya was killed after DeAllen discovered that Taya was transgender.

This episode also profiles the unsolved homicide of 19-year-old Aaron Thomas Brice who was shot to death at a Halloween party in the 11500 block of Manor Stone Lane in Columbia on October 31, 2009.

This episode profiles the gang related murder of 20-year-old Petro Taylor, who was brutally beaten, stabbed, and burned alive by members of The Bounty Hunters and Tree Top Piru gang on December 28, 2008.

This episode also profiles the unsolved murder of 14-year-old Teneisha Nikiya Whitfield, who was found shot to death in a burning vehicle in the 9700 block of Covered Wagon Drive in North Laurel on July 6, 1996.

This episode profiles the hate related murder of 37-year-old Christopher William Jones who was stabbed to death by 25-year-old Gary William Mick at the Admiral Fell Inn on June 29, 2021.

This episode also profiles the unsolved murder of 32-year-old May Ann Atilano Siason, who was found beaten in her home in the 3800 block of Perryhurst Place in Nottingham on February 9, 2017.