This episode profiles the murder suicide of Christopher Alan Wood who killed his wife Francis Billotti-Wood, his 5-year-old son Chandler Wood, his 4-year-old son, Gavin Wood, and his 2-year-old daughter, Fiona Wood. He then shot and killed himself with a shotgun. This episode also examines the unsolved shooting homicide of 22 year old LaRelle Amos, who was shot during Labor Day Weekend in 2012, in Baltimore City, while cleaning up after a party.

This season finale episode of Season Three Relationship Murders profiles the stabbing murder of Jacqueline Smith by the hands of her husband, Keith Smith, who blamed his wife's murder on panhandlers in the neighborhood. This episode also profiles the murder of transgender Mia Henderson who was brutally stabbed in the 3400 block Piedmont Avenue in West Baltimore. Mia, was the older sister of NBA player, Reggie Bullock.

This episode profiles the murder of 32-year-old Tracey Leigh Gardner Tetso who was reported missing by her husband, Dennis Tetso, when she failed to show up at a planned Montley Crue concert in March of 2005. Dennis maintains he knows nothing about Tracey's "disappearance" and her body or remains have never been found. This episode also profiles the unsolved shooting murder of 29-year-old transgender Kelly Young who was shot in the 2200 block of Barclay Street in East Baltimore.

This episode profiles the shooting murder of Pfc. Karlyn Ramirez Kearney by her husband Army Sgt. Maliek Kearney and the unsolved stabbing murder of 25-year-old transgender Johanna Metzger.

This episode profiles the shooting murder of William Ray Porter that was orchestrated by his wife, Karla Porter. This case became the first time a battered wife syndrome defense was used in a murder for hire homicide. This episode examines the unsolved shooting murder of 27-year-old transgender Ashanti Carmon in Fairmount Heights.

This episode profiles the murder of 38-year-old Nancy Lee Riggins, who was murdered by her husband 39-year-old Paul Stephen Riggins, who was having an affair with their 15-year-old babysitter. This episode also profiles the unsolved shooting murder of 37-year-old transgender Tydi Danbury who was shot several times in the 1900 block of Lanvale Street in Baltimore.

This episode profiles Maryland fugitive Bhadresh Kumar Chetanbhai Patel who brutally beat and stabbed his wife, 22 year old Palek Patel, in a Dunkin Donuts in Hanover Maryland. Bhadresh is listed on the FBI's Ten Most Wanted Fugitives List and there is a $100,000 reward for his capture. This episode also profiles the unsolved shooting death of 17 year old transgender Bailey Reeves who was shot multiple times in northeast Baltimore.

This episode profiles the female serial killer Josephine Gray, who murdered two husbands and a boyfriend, who was also her cousin. This episode's unsolved homicide is the strangulation murder of Anthony "Tyra" Trent who was found in a vacant rowhome in northwest Baltimore.

This episode profiles the beating murder of 22 year old University of Virginia Lacrosse player, Yeardley Love by the hands of her ex-boyfriend, 22 year old University of Virginia Lacrosse player, George Wesley Huguely. This episode's unsolved homicide examines the shooting murder of transgender, 32 year old Crystal Edmonds in northwest Baltimore.

This episode profiles the double murderer, 24 year old David Lee Miller, who shot his 24 year old, 7 month pregnant ex-girlfriend Elizabeth Walters, and the attempted murder of her friend in the Parkway Crossing Shopping Center in northeast Baltimore on the morning of June 11, 2007. David became the first person in Maryland's legal history to be charged under it's newly enacted Maryland's Fetal Law. This episode's unsolved homicide profiles the shooting death of transgender Alphonza Watson who was fatally shot in the 2400 block of Guilford Road near Charles Village on March 22, 2017.