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Join Dr. Anthony Fauci and Dr. Michael Koren as they discuss the public health events that have punctuated Dr. Fauci's life. The doctors discuss the difficulties of the HIV epidemic in the 1980's and how Dr. Fauci's early career decision to pursue this emerging threat helped inform and prepare him for the COVID-19 pandemic. Doctors Koren and Fauci wade through the myriad controversies surrounding the public health response to the COVID-19 pandemic; from its origins, the importance of vaccines, and the balance of public health and individual rights. Finally, the two speak about the difficulty of public health communication during an evolving situation and the importance of high-quality data from sources like clinical trials.

Koren's Key Takeaways:

• Scientific integrity and the credible medical information are critical to public health
• Previous healthcare crises can help inform current and future ones
• Balancing personal rights and public health mandates is a challenge

Recorded 1/17/2025


Reference:

Moreira Jr, Edson D., Nicholas Kitchin, Xia Xu, Samuel S. Dychter, Stephen Lockhart, Alejandra Gurtman, John L. Perez et al. "Safety and efficacy of a third dose of BNT162b2 Covid-19 vaccine." New England journal of medicine 386, no. 20 (2022): 1910-1921. https://www.nejm.org/doi/full/10.1056/NEJMoa2200674


COVID update: the AstraZeneca antibody vaccine was just approved overseas. Interested in the next generation of oral COVID vaccine? Contact ENCORE Research group at (904) 760-0166 or visit ENCOREdocs.com

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Recent guidelines from the Surgeon General indicate that even moderate alcohol consumption poses significant health risks, particularly increasing the likelihood of several cancers. In this episode, cardiologist Dr. Michael Koren and GI specialist Dr. Bharat Misra analyze the data on alcohol and if it aligns with the Surgeon General's recommendation to add warning labels to alcohol. 

The doctors suggest limiting the number of days per week alcohol is consumed and challenge traditional views to look at effects on cancers, heart health, and social aspects. They emphasize the need for personal assessment of drinking habits and highlights the importance of having good data and informed conversations with healthcare professionals about individual risks associated with alcohol. 

Koren's Key Takeaways:

• Alcohol use is complex and affects many body and social systems
• Talking to your doctor is the best way to determine your risk
• We could use more high-quality data on alcohol use and its effects

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On this week's Monday Morning Minute, Dr. Michael Koren and Kevin Geddings discuss the worry uncertainty brings in a changing government landscape and how this affects healthcare. They discuss the stress of not knowing what to expect with competing visions from the incoming administration and how the structure of clinical research trials provides consistency in uncertain times. The two talk about what may change with the second Trump administration, including research funding, healthcare dollars, and access to medicines like the GLP-1 inhibitors Maunjaro and Ozempic that help with diabetes, high blood pressure, and weight loss.

Koren's Three Key Takeaways:

• The new administration's health policies are unclear
• Access to GLP-1 inhibitor medications may change
• Clinical research provides consistent health monitoring

Recorded January 20, 2025

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Dr. Michael Koren sits down with Alexandria Clark and Anna Fehr of One of a Kind (1-OAK) Clinical Research to discuss their bold decision to launch a clinical research company in 2021, shortly after the disruptions caused by the COVID-19 pandemic. Dr. Koren reflects on how the pandemic reshaped the clinical research landscape, forcing the closure of many smaller sites which couldn't continue seeing patients in-person. Alexandria and Anna saw an opportunity in the vacuum to build a business specializing in high-need areas like asthma, immunology, and gastroenterology. The conversation also explores the unique hurdles of establishing a new clinical research site and the importance of adaptability, planning, community, and instruction for both patients and physicians.

Koren's Key Takeaways:

• The COVID-19 pandemic changed the clinical research landscape
• Starting a new clinical research site can be a challenge and must be done with care and tact
• Clinical research sites act as a resource for the community where they are located

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Cardiologist and research scientist with ENCORE Research Group, Dr. Michael Koren highlights the importance of monitoring your key health numbers with Kevin Geddings. The two talk about the importance of checking weight, cholesterol, and blood pressure, emphasizing consistency in measurement practices for accurate tracking. They discuss newer numbers to check for cardiovascular health, including lipoprotein(a) and hsCRP, a marker for vascular inflammation. Both of these metrics are gaining recognition for their role in long-term heart health.

Koren's 3 Key Takeaways:

• Prevention and early detection are critical to long-term health
• Consistency is the key to making sure numbers are accurate
• Clinical research is developing new methods of tracking health

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Have a question for Dr. Koren? Email him at [email protected]

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Join Dr. Koren and Dr. Ridker for part 2, as they examine the effects of silent inflammation on heart health, emphasizing the importance of understanding specific body signals and the biomarker hsCRP. They also discuss the utility of hsCRP testing as a vital marker for predicting cardiovascular risk due to silent inflammation. The doctors explain how inflammation may play a bigger part in heart disease than many patients - and even some doctors - guess.

Koren's Key Takeaways:

• Inflammation plays a critical part in chronic disease, including heart disease
• Medicine is constantly evolving, bridging the gap between research and practice
• Patients and physicians have to work together to push science forward

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Have a question for Dr. Koren? Email him at [email protected]

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Dr. Michael Koren welcomes Dr. Paul Ridker, the leading expert in inflammation and cardiovascular disease, Professor of Medicine at Harvard University, and director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital. Dr. Ridker explains how his career began with challenging traditional medical assumptions, specifically the textbook risk factors for heart attack, and how this manifested in an intense interest in inflammation. The conversation continues into Dr. Ridker's work on groundbreaking research investigating how chronic inflammation drives diseases of aging, including heart attack, stroke, and cancer.

The doctors then highlight the pivotal discoveries in inflammation management, particularly the use of statin drugs. Dr. Ridker recounts how statins reduce heart attacks and strokes in individuals with high inflammation markers, regardless of cholesterol levels. These findings revolutionized cardiovascular treatment and emphasized the need to integrate inflammation control into preventive medicine. 

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Last week the Surgeon General of the United States, Vivek Murthy, urged congress to pass a law requiring warning labels on alcohol showing the link between even light drinking and gastrointestinal cancers, but is this a good idea? Dr. Michael Korn talks with Kevin Geddings to discuss the balance between the gastrointestinal risks associated with alcohol consumption and its potential cardiovascular benefits while advocating for informed personal choices regarding health. 

Koren's Top Takeaways
• Weigh the relative risks of gastrointestinal and cardiovascular disease
• Talk to your doctor about your current situation
• Dry January may be a good idea to make sure you aren't addicted to alcohol

Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at [email protected]

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This episode of MedEvidence! features a compelling discussion between cardiologist and medical researcher Dr. Michael Koren and 20th U.S. Surgeon General Dr. Jerome Adams. Dr. Adams shares his unique journey from growing up in rural Maryland to becoming the nation's top doctor, highlighting the role of personal experience in shaping his commitment to public health. The conversation delves into the challenges of navigating evidence-based medicine during crises like COVID-19, the importance of addressing social determinants of health, disease management versus health promotion, and the tension between individual patient care and public health priorities. With insights into policymaking, scientific communication, and trust-building, this episode offers a thoughtful exploration of how evidence shapes decisions in medicine and public health.

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Unlock the secrets to successful clinical trials with Dr. Michael Koren and Doug Denham in part 2 of this podcast. The doctors explore participant retention strategies that make a difference to science and to patients. From obesity studies to cholesterol conditions, Drs. Koren and Denham share their experiences  with keeping participants engaged and ensuring trial success. They discuss the importance of personal relationships with patients, maintaining a supportive environment, and the power of setting realistic expectations. 

The doctors also emphasize the necessity of clear communication, especially during Serious Adverse Events, and the importance maintaining study blindness to prevent bias. The doctors close by discussing the importance of trial volunteers and how the industry can improve communication after a trial is complete.

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