This week, Christina and Jamie are joined by Edie Falco, who starred on "The Sopranos" with Jamie. They share their perceptions of each other while working on the show, and discuss parenting, cancer, the importance of being vulnerable, and more.

Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

On the first episode of MeSsy, Christina and Jamie share how they became friends and what they've learned from each other. They also discuss the importance of setting boundaries, how they've learned to handle doubt, and much more.

Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

Jamie-Lynn Sigler is a paid spokesperson for Novartis. This podcast is independent from Jamie-Lynn Sigler’s collaboration with Novartis.

Christina Applegate and Jamie-Lynn Sigler are getting vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life. New episodes available beginning March 19th!

This show is executive produced by Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick