In this episode, Martin is jouned by Dr Luke Moore (@dr_luke_moore), Consultant in Infectious Diseases, Clinical Microbiology and Virology at Chelsea and Westminster NHS Foundation Trust in the UK and Honorary Clinical Senior Lecturer at Imperial College London. We discuss the recent paper from his group (https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06159-8), the findings of which were quite surprising. Why did bacteraemia from Enterobacterales go down, Staph. aureus and Strep. pneumoniae stay the same and Coag neg staphylococci increase? Absolutely more questions are raised by this interesting paper, many of which if answered could provide benefits for antimicrobial stewardship and infection prevention activities.