My Longevity Experiment

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC (https://shorturl.ac/7b75r)

Links:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395819/

https://clinicaltrials.gov/ct2/show/NCT04510194

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30033-7/fulltext

https://www.cidrap.umn.edu/news-perspective/2020/12/diabetes-drug-linked-lower-covid-19-death-rate-women

https://www.medscape.com/viewarticle/935724

https://medicalxpress.com/news/2020-12-metformin-covid-death-women.html

The University of Minnesota Medical School and the United Health Group researchers found that metformin was associated with significantly reduced COVID-19 death risks in women in one of the world's largest observational studies of COVID-19 patients.

Diabetes and COVID-19

Severe COVID-19 outcomes for people with diabetes have been widely observed, including greater risk of intensive care unit admission, intubation for mechanical ventilation and death,

These outcomes could possibly be related to less effective glycemic or blood sugar control in these patients.

Metformin is an established, generic medication for managing blood sugar levels in patients with type 2 diabetes.

It also reduces inflammation proteins like TNF-alpha that appear to make COVID-19 worse.

The Study

The team analyzed 6,256 individuals with type 2 diabetes or obesity who were hospitalized with COVID-19 and assessed whether or not the use of metformin was associated with decreased mortality

The investigators identified 2,333 adults who had filled 90-day metformin prescriptions within 12 months of their COVID-19 diagnosis (with a mean age 73), and 3,923 non-users of Metformin (with a median age of 76)

They then assessed the associations between home metformin use and risk of in-hospital death from COVID-19.

The results

They found an association that women with diabetes or obesity, who were hospitalized for COVID-19 disease and who had filled a 90-day metformin prescription before hospitalization, had a 21% to 24% reduced likelihood of mortality compared to similar women not taking the medication.

There was no significant reduction in mortality among men.

Carolyn Bramante, MD, MPH, the principal investigator and assistant professor in the Department of Medicine at the University of Minnesota Medical School said "Observational studies like this cannot be conclusive, but contribute to growing bodies of evidence. Seeing a bigger association with protection in women over men may point towards inflammation reduction as a key way that metformin reduces risk from COVID-19. However, more research is needed,"

She also said:

"A large database covering different geographic areas is rarely available. We were fortunate to have the opportunity to do this research alongside UnitedHealth Group."

Deneen Vojta, MD, executive vice president of Enterprise Research and Development at UnitedHealth Group said, "While effective therapies to mitigate the harm of the SARS-CoV-2 virus are being developed, it is important that we also look to, and evaluate commonly used medications with good safety profiles for their potential to combat the virus,"

New Drug Application

Christopher Tignanelli, MD, assistant professor in the Department of Surgery at the University of Minnesota Medical School and Carolyn Bramante, together have submitted an investigational new drug application to the Food and Drug Administration for use of metformin for COVID-19 treatment and prevention.

 The FDA approved this application.

 FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

Signal to Noise by Scott Buckley https://soundcloud.com/scottbuckley

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/signal-to-noise

Music promoted by Audio Library https://youtu.be/of0Ei_T4isc

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

 Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support.

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC (https://shorturl.ac/7b75r)

Links:

https://bit.ly/3ft1f7r

https://bit.ly/3kQ4S8l

https://prn.to/36PRa0l

https://bit.ly/2UWW0U5

The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center, Tel Aviv University announced that according to a new study, for the first time in humans, two key biological hallmarks of aging, telomere length shortening, and the accumulation of senescent cells have been reversed.

Hallmarks of Aging

The biological deterioration of aging is cited as a major risk factor for cancer, cardiovascular diseases, diabetes, dementia and Alzheimer's.

At the cellular level, two key hallmarks of the aging process are:

The shortening of telomere length, of approximately 20-40 bases per year, which is associated with a variety of serious life-threatening illnesses, and

The accumulation of senescent cells, the so-called "old malfunctioning cells," which inhibit cell proliferation. The accumulation of senescence contributes to many age-associated conditions and illnesses, while elimination of those cells can reverse them, as shown in previous animal studies.

The Study Team

The clinical trial was conducted by Prof. Efrati, MD, from the Faculty of Medicine and Sagol School of Neuroscience at Tel Aviv University, and Dr. Amir Hadanny, MD, Chief Medical Research Officer of The Sagol Center for Hyperbaric Medicine and Research and co-author of the study.

It is the first study to evaluate whether HBOT can affect telomere length and senescence using their specific Hyperbaric Oxygen Therapy HBOT protocol.

The Study

The scientific included 35 healthy adults aged 64 and older who did not undergo any lifestyle, diet or medication adjustments.

Each patient was placed in a hyperbaric chamber for 90 minutes a day, for five days a week, over three months while breathing 100% oxygen through a mask.

The pressurized chamber allows more oxygen to be dissolved into the tissues and mimics a state of hypoxia, or oxygen shortage, which is known to have regenerating effects.

Whole blood samples were collected prior to treatment, at the 30th and 60th session, and one to two weeks following the last HBOT session, to assess peripheral blood mono-nuclear cells telomere length and senescence.

Statement

In a statement Prof. Shai Efrati said, "After dedicating our research to exploring its impact on the areas of brain functionality and age-related cognitive decline, we have now uncovered for the first time in humans, Hyperbaric Oxygen Therapy's biological effects at the cellular level in healthy aging adults."

Since telomere shortening is considered the 'Holy Grail' of the biology of aging, many pharmacological and environmental interventions are being extensively explored in the hopes of enabling telomere elongation.

The significant improvement of telomere length shown during and after these unique Hyperbaric Oxygen Therapy protocols provides the scientific community with a new foundation of understanding that aging can, indeed, be targeted and reversed at the basic cellular-biological level.

Results

Results found that the telomere length of T helper, natural killer and B cells increased significantly, by over 20% following HBOT.

 The most significant change was in B cells, which increased at the 30th session, 60th session and post HBOT by 25.68%, 29.39% and 37.63% respectively.

In addition, there was a significant decrease in the number of senescent T helpers by -37.30%, www.Eurekalert.com website summarized the results as a lengthening of up to 38% of the telomeres, as well as a decrease of up to 37% in the presence of senescent cells.

Statement

Dr. Hadanny stated that "Until now, interventions such as lifestyle modifications and intense exercise were shown to have some inhibition effect on the expected telomere length shortening. However, what is remarkable…is that in just three months of HBOT, we were able to achieve such significant telomere elongation; rates far beyond any of the current available interventions or lifestyle modifications.

With this pioneering study, we have opened a door for further research on the prolonged cellular impact of HBOT to reverse the aging process."

DISCLAIMER: The Video Content has been made available for informational and educational purposes only. The video creator does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of the Video Content. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The video creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Video Content, which is provided as is, and without warranties.

FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

Signal to Noise by Scott Buckley https://soundcloud.com/scottbuckley

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/signal-to-noise

Music promoted by Audio Library https://youtu.be/of0Ei_T4isc

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC

Links:

https://pubmed.ncbi.nlm.nih.gov/28620474/

https://pubmed.ncbi.nlm.nih.gov/25272572/

https://pubmed.ncbi.nlm.nih.gov/18417116/

https://pubmed.ncbi.nlm.nih.gov/23675073/

https://pubmed.ncbi.nlm.nih.gov/18827577/

https://pubmed.ncbi.nlm.nih.gov/23044824/

https://pubmed.ncbi.nlm.nih.gov/20943792/

https://pubmed.ncbi.nlm.nih.gov/27294919/

https://pubmed.ncbi.nlm.nih.gov/27710596/

https://pubmed.ncbi.nlm.nih.gov/27187333/

https://pubmed.ncbi.nlm.nih.gov/18187018/

https://pubmed.ncbi.nlm.nih.gov/21625024/

https://pubmed.ncbi.nlm.nih.gov/20548131/

https://pubmed.ncbi.nlm.nih.gov/19149749/

https://www.spandidos-publications.com/or/33/6/2659

https://pubmed.ncbi.nlm.nih.gov/28677813/

https://pubmed.ncbi.nlm.nih.gov/28264020/

https://pubmed.ncbi.nlm.nih.gov/24223637/

https://pubmed.ncbi.nlm.nih.gov/27186419/

https://pubmed.ncbi.nlm.nih.gov/26904161/

https://pubmed.ncbi.nlm.nih.gov/29736217/

https://pubmed.ncbi.nlm.nih.gov/27479153/

https://pubmed.ncbi.nlm.nih.gov/27405810/

https://pubmed.ncbi.nlm.nih.gov/20517329/

https://pubmed.ncbi.nlm.nih.gov/21443986/

https://pubmed.ncbi.nlm.nih.gov/28377278/

http://www.foodandnutritionjournal.org/vol04nospl-issue-conf-october-2016/bioavailability-of-quercetin/

https://www.healthline.com/nutrition/quercetin#1

https://selfhacked.com/blog/quercetin-23-scientifically-proven-benefits-quercetin/

The antioxidant quercetin is sometimes called the “Head or Master Flavonoid.” People have said it is one of the best natural antihistamines on the market. It can, allegedly, stabilize mast cells and reduce inflammation.

A Mast cell serves the same general functions in the body and central nervous system; things such as effecting or regulating allergic responses, innate and adapted immunity, autoimmunity and inflammation.

What is Quercetin?

Quercetin is a plant flavanol from the flavonoid group of polyphenols.

It’s one of the most abundant antioxidants in the diet and plays an important role in helping your body combat the free radical damage that has been linked to some chronic diseases.

Antioxidants

Antioxidants are compounds that can bind to and neutralize free radicals. Free radicals are unstable molecules that may cause cellular damage when their levels become too high

Damage caused by free radicals has been linked to numerous chronic conditions, including cancer, heart disease and diabetes

 In addition, its antioxidant properties may help reduce:

o  inflammation

o  allergy symptoms

o  blood pressure

Food Sources

Foods that commonly contain quercetin include:

o  Onions

o  Apples

o  Grapes

o  Berries

o  Broccoli

o  Citrus fruits

o  Cherries

o  Green tea, and for me thankfully coffee and red wine

Inflammation

Free radicals may do more than simply damage your cells.

Research shows that high levels of free radicals may help activate genes that promote inflammation, ergo high levels of free radicals may lead to an increased inflammatory response.

While a little inflammation is necessary to help your body heal and fight infections, persistent inflammation is linked to health problems, including certain cancers, as well as heart and kidney disease.

Studies show that quercetin may help reduce inflammation.

In test-tube studies, quercetin reduced markers of inflammation in human cells, including the molecules ‘tumor necrosis factor alpha (TNFα)’ and interleukin-6, both of these are a pro-inflammatory cytokines.

Scientific Study

An 8-week study of 50 women with rheumatoid arthritis observed that participants who took 500 mg of quercetin a day experienced a significant reduction in:

o  Early morning stiffness

o  Morning pain

o  And after-activity pain

 They also had reduced markers of inflammation, such as TNFα, compared to those who received a placebo.

While these findings are promising, more human research is needed to fully understand the compound’s potential anti-inflammatory properties.

Allergies

Quercetin’s potential anti-inflammatory properties may also provide allergy symptom relief.

Test-tube and animal studies found that it may block enzymes involved in inflammation and suppress inflammation-promoting chemicals, such as histamine.

For example, one study showed that taking quercetin supplements suppressed peanut-related anaphylactic reactions in mice.

Still, it’s unclear whether the compound has the same effect on allergies in humans, so more research is needed before it can be recommended as an alternative treatment.

Cancer

Quercetin may have anti-cancer effects because it has certain antioxidant properties.

In a review of test-tube and animal studies, quercetin was found to suppress cell growth and induce cell death in prostate cancer cells.

Other test-tube and animal studies observed that the compound had similar effects in liver, lung, breast, bladder, blood, colon, ovarian, lymphoid and adrenal cancer cells.

 Though these findings are promising, many more human studies are needed before quercetin can be recommended as an alternative treatment for cancer.

Brain Disorders

Quercetin may lower your risk of chronic brain disorders. Research suggests that quercetin’s antioxidant properties may help protect against degenerative brain disorders, such as Alzheimer’s and dementia.

In one study, mice with Alzheimer’s disease received quercetin injections every 2 days for 3 months. By the end of the study, the injections had reversed several markers of Alzheimer’s, and the mice performed much better during learning tests.

In another study, a quercetin-rich diet reduced the markers of Alzheimer’s disease and improved brain function in mice at the early to middle stage of the condition. However, the diet had little to no effect on animals with middle to late stage Alzheimer’s.

Coffee is a popular beverage that has been linked to a lower risk of Alzheimer’s disease. Again, research shows that quercetin, not caffeine, is the primary compound in coffee that’s responsible for its potential protective effects against this illness.

Though these findings are promising, more research in humans is needed.

Blood Pressure

 Quercetin may also reduce blood pressure, high blood pressure affects 1 in 3 American adults. It raises your risk of heart disease and is the leading cause of death in the United States.

 When mice with high blood pressure were given quercetin daily for 5 weeks, their systolic and diastolic blood pressure values decreased by an average of 18% and 23%, respectively.

 A review of 9 human studies in 580 people found that taking more than 500 mg of quercetin a day in supplement form, reduced systolic and diastolic blood pressure by an average of 5.8 and 2.6, respectively.

 Although these findings are promising, more human studies are needed to determine whether the compound could be an alternative therapy for treating high blood pressure

Quercetin Supplements

You can purchase quercetin as a dietary supplement, indeed DoNotAge.org now carry it in capsules form.

Typical dosages range from 500 to 1,000 mg per day.

 Additionally, some research indicates that quercetin has a synergistic effect when quercetin is combined with other flavonoid supplements, such as resveratrol or Genistein.

Side effects

Quercetin is found naturally in many fruits and vegetables and so is safe to consume and a supplement, it appears to be generally safe with little to no side effects.

In some instances, taking more than 1,000 mg of quercetin per day may cause mild symptoms like headaches, stomach aches and/or or tingling sensations.

When consumed in food, quercetin is safe for pregnant and woman who are breastfeeding.

However, studies on the safety of quercetin as a supplement are few, so you should avoid taking quercetin supplements if you’re pregnant or nursing.

 As with any supplement, consult your healthcare provider before taking quercetin, as it can interact with some medications, including antibiotics and blood pressure medications.

FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

Signal to Noise by Scott Buckley https://soundcloud.com/scottbuckley

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/signal-to-noise

Music promoted by Audio Library https://youtu.be/of0Ei_T4isc

Lonely Soul by Rexlambo https://soundcloud.com/rexlambo​

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/-lonely-soul​

Music promoted by Audio Library https://youtu.be/_ozYQF0iA6k

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support.

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC (https://shorturl.ac/7b75r)

Links:

https://pubmed.ncbi.nlm.nih.gov/18358827/

https://pubmed.ncbi.nlm.nih.gov/17609490/

https://pubmed.ncbi.nlm.nih.gov/22301923/

https://pubmed.ncbi.nlm.nih.gov/17420419/

https://pubmed.ncbi.nlm.nih.gov/14654748/

https://pubmed.ncbi.nlm.nih.gov/20823377/

https://pubmed.ncbi.nlm.nih.gov/17513403/

https://pubmed.ncbi.nlm.nih.gov/11684527/

https://pubmed.ncbi.nlm.nih.gov/10917931/

https://pubmed.ncbi.nlm.nih.gov/11235000/

https://pubmed.ncbi.nlm.nih.gov/18716168/

https://pubmed.ncbi.nlm.nih.gov/18716168/

https://pubmed.ncbi.nlm.nih.gov/16027246/

https://pubmed.ncbi.nlm.nih.gov/16505260/

https://pubmed.ncbi.nlm.nih.gov/16505260/

https://pubmed.ncbi.nlm.nih.gov/20858571/

https://pubmed.ncbi.nlm.nih.gov/16702322/

https://pubmed.ncbi.nlm.nih.gov/19735513/

https://pubmed.ncbi.nlm.nih.gov/16794461/

https://pubmed.ncbi.nlm.nih.gov/22892813/

https://pubmed.ncbi.nlm.nih.gov/15549276/

https://bmcchem.biomedcentral.com/articles/10.1186/1752-153X-5-5

https://nutritiondata.self.com/facts/sweets/10638/2

https://www.healthline.com/nutrition/7-health-benefits-dark-chocolate#TOC_TITLE_HDR_1

https://www.medicalnewstoday.com/articles/dark-chocolate

https://www.everydayhealth.com/diet-and-nutrition-pictures/delicious-reasons-to-eat-dark-chocolate.aspx

https://www.ecowatch.com/health-benefits-eating-dark-chocolate-2309128070.html

It’s a known fact that Dark chocolate is loaded with nutrients that can positively affect your health.

Made from the seed of the cocoa tree, it is one of the best sources of antioxidants on the planet.

Studies show that dark chocolate (not milk chocolate) can improve your health and lower the risk of heart disease.

Nutrition

Dark chocolate with a high cocoa content is actually very nutritious.

A 100-gram bar of dark chocolate with 70–85% cocoa contains:

o  11 grams of fiber

o  67% of the RDI for iron

o  58% of the RDI for magnesium

o  89% of the RDI for copper

o  98% of the RDI for manganese

It also has plenty of potassium, phosphorus, zinc and selenium.

Of course, 100 grams (3.5 ounces) is a fairly large amount and all these nutrients also come with 600 calories, for this reason, dark chocolate is best consumed in moderation.

 The fatty acid profile of cocoa and dark chocolate is also excellent. The fats are mostly saturated and monounsaturated, with small amounts of polyunsaturated fat.

 It also contains stimulants like caffeine, but is unlikely to keep you awake at night as the amount of caffeine is very small compared to coffee.

Antioxidants

Powerful Source of Antioxidants

ORAC stands for “oxygen radical absorbance capacity.” It is a measure of the antioxidant activity of foods. This is where researchers set a group of free radicals (bad) against a sample of a food and see how well the antioxidants in the food can “disarm” the radicals.

 The biological relevance of ORAC values is questioned, because it’s measured in a test tube and may not have the same effect in the body. However, it is worth mentioning that raw, unprocessed cocoa beans are among the highest-scoring foods that have been tested.

Dark chocolate is loaded with organic compounds that are biologically active and function as antioxidants. These include polyphenols and among others.

One study showed that cocoa and dark chocolate had more antioxidant activity, polyphenols and flavanols than any other fruits tested, which included blueberries and acai berries.

Blood Flow & Pressure

May Improve Blood Flow and Lower Blood Pressure

The flavanols in dark chocolate can stimulate the endothelium, the lining of arteries, to produce nitric oxide, one of the functions of nitric oxide is to send signals to our arteries to relax, which lowers the resistance to blood flow and therefore reduces blood pressure.

Many controlled studies show that cocoa and dark chocolate can improve blood flow and lower blood pressure, though the effects are usually mild.

 HDL & LDL

Consuming dark chocolate can improve several important risk factors for heart disease.

In a controlled study, cocoa powder was found to significantly decrease oxidized LDL cholesterol in men. It also increased HDL and lowered total LDL for those with high cholesterol.

 Oxidized LDL means that the LDL had reacted with free radicals; this makes the LDL particle itself reactive and capable of damaging other tissues, such as the lining of the arteries in your heart.

 It makes sense that cocoa lowers oxidized LDL as it contains an abundance of powerful antioxidants that do make it into the bloodstream and protect lipo-proteins against oxidative damage.

Dark chocolate can also reduce insulin resistance, which is another common risk factor for many diseases like heart disease and diabetes.

Heart Disease

May Reduce Heart Disease Risk

In a study of 470 elderly men, cocoa was found to reduce the risk of death from heart disease by 50% over a 15-year period.

Another study revealed that eating chocolate two or more times per week lowered the risk of having calcified plaque in the arteries by 32%.

 Another study showed that eating dark chocolate more than 5 times per week lowered the risk of heart disease by 57%

 Sun Damage

May Protect Your Skin from the Sun.

The bioactive compounds in dark chocolate may also be great for your skin. The flavanols can protect against sun damage, improve blood flow to the skin and increase skin density and hydration.

 The minimal erythemal dose (or MED) is the minimum amount of UVB rays required to cause redness in the skin 24 hours after exposure. In one study of 30 people, the MED more than doubled after consuming dark chocolate high in flavanols for 12 weeks.

 So, maybe consider loading up on dark chocolate prior to your beach vacation.

Brain Function

More good news, dark chocolate may also improve the function of your brain.

One study of healthy volunteers showed that eating high-flavanol cocoa for five days improved blood flow to the brain.

 Cocoa may also significantly improve cognitive function in elderly people with mental impairment. It may improve verbal fluency and several risk factors for disease.

Additionally, cocoa contains stimulant substances like caffeine, which may be a key reason why it can improve brain function in the short term.

There is considerable evidence that cocoa can provide powerful health benefits, being especially protective against heart disease.

Of course, this doesn’t mean you should go all out and consume lots of chocolate every day. It is still loaded with calories and easy to overeat.

 Also be aware that a lot of the chocolate on the market is not healthy, but good quality dark chocolate with 70% or higher cocoa content.

 Dark chocolates does contain some sugar, but the amounts are usually small and the darker the chocolate, the less sugar it will contain

 DISCLAIMER: The Video Content has been made available for informational and educational purposes only. The video creator does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of the Video Content. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The video creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Video Content, which is provided as is, and without warranties.

 FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

Lonely Soul by Rexlambo https://soundcloud.com/rexlambo​

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/-lonely-soul​

Music promoted by Audio Library https://youtu.be/_ozYQF0iA6k

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC 

A study by the Boston University has shown that having sufficient levels of Vitamin D can prevent the conditions of Covid-19 patients’ from deteriorating and it can even reduce their need for oxygen.

The researchers at the Boston University stated that only 9.7% of patients who were older than 40 years of age and who were vitamin D sufficient succumbed to the infection. Compared to 20% of people who had a circulating level of <30 nanograms per milliliter of 25-hydroxy-vitamin D; a measure of Vitamin D in the body.

CRP or C reactive protein is commonly analyzed to check the inflammation levels caused by an infection. The higher the inflammation, usually the greater the infection

A significant reduction in serum CRP, an inflammatory marker, suggests that vitamin D sufficiency also may help modulate the immune response, possibly by reducing risk of a cytokine storm in response to this viral infection.

Boston University School of Medicine

During the study, the Vitamin D levels of 235 hospitalized COVID-19 patients were measured.

“This study provides direct evidence that vitamin D sufficiency can reduce the complications, including the cytokine storm and ultimately death from COVID-19.”

A cytokine is a small protein important in the cell signaling process.

A cytokine storm is where too many proteins are released into the blood too quickly, which can be deadly.

Vitamin D and the immune response

Patients who were Vitamin D sufficient had significantly lower blood levels of the inflammatory marker CRP and had a higher total blood lymphocyte count; this suggests that Vitamin D sufficiency had improved their immune function.

The researchers concluded that the beneficial effect on the immune system may also reduce the risk of acquiring this potentially life-threatening viral infection in the first place.

Only 32.8% of participants in the study had sufficient Vitamin D levels.

The severity of clinical outcomes from COVID-19 and mortality were reduced in patients who were vitamin D sufficient.

Clinical features were also significantly different in patients who were Vitamin D sufficient, they had a lower risk of becoming unconscious and becoming hypoxic.

Signal to Noise by Scott Buckley https://soundcloud.com/scottbuckley

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/signal-to-noise

Music promoted by Audio Library https://youtu.be/of0Ei_T4isc

Lonely Soul by Rexlambo https://soundcloud.com/rexlambo​

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/-lonely-soul​

Music promoted by Audio Library https://youtu.be/_ozYQF0iA6k

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support.

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC

Links: 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257679/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/#:~:text=Vitamin%20D%20can%20modulate%20the,an%20increased%20susceptibility%20to%20infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579593/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952478/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425186/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231123/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305922/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035876/

https://www.health.harvard.edu/blog/vitamin-d-whats-right-level-2016121910893

https://www.hsph.harvard.edu/nutritionsource/vitamin-d/

https://www.oatext.com/after-vital-study-is-vitamin-d-supplementation-necessary.php#gsc.tab=0

https://medlineplus.gov/vitaminddeficiency.html#:~:text=Vitamin%20D%20deficiency%20can%20lead,to%20become%20soft%20and%20bend.

https://academic.oup.com/ajcn/article/89/5/1321/4596773

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/calcium-plus-vitamin-d-supplementation-and-fat-mass-loss-in-female-very-lowcalcium-consumers-potential-link-with-a-calciumspecific-appetite-control/623D71E0A965E910C48903089FA7B56C

https://jamanetwork.com/journals/jama/fullarticle/204651

https://www.healthline.com/health/food-nutrition/benefits-vitamin-d#how-much-you-need

https://www.kazidomi.com/en/blog/vitamin-d3-benefits-n380

https://www.sciencedaily.com/releases/2018/02/180226122548.htm#:~:text=Magnesium%20status%20is%20low%20in,D%20supplements%2C%22%20says%20Razzaque.

Vitamin D is really not a vitamin. Vitamins are special nutrients that the body needs but cannot make, so they must be obtained from what we eat or by supplements. Because our bodies can make Vitamin D in our skin when it is exposed to sunlight, Vitamin D is considered a hormone.

Vitamin D2 and Vitamin D3

Vitamin D is actually available in two forms: vitamin D2 and vitamin D3; the main difference really is just the source.

·     D2 is manufactured from plants and fungi (and often the type that’s included in fortified milk, bread, and cereal)

·     D3 is created from animal products and is the closest to that which is naturally made by the body through sunlight exposure.

Because of this familiarity, most doctors and nutritionists recommending supplementing with vitamin D3.

 The Benefits of Vitamin D3

Vitamin D3 can have an impact on as many as 2,000 different genes within the body, and has a direct role on far more aspects of health than many might realize.

·     Vitamin D receptors are found in nearly every cell, and as soon as Vitamin D binds to a receptor, it turns genes on or off, prompting changes at the cellular level

·     Studies completed over the last two decades have proven that this process turns off cancer-causing genes, turns on immune-protective genes, and even tells cells which vitamins and minerals to absorb.

This all has a great effect on many important body processes, let’s look at a few:

Food Sources of Vitamin D

Very few foods actually contain vitamin D naturally.

Because of this, some foods are fortified, which means vitamin D is added during the production process.

Foods that do contain vitamin D include:

·      salmon

·      sardines

·      egg yolk

·      shrimp

·      milk (fortified)

·      yogurt (fortified)

It can be hard to get enough vitamin D each day through sun exposure and food alone, so taking vitamin D supplements can help

Bone Health

Correct Vitamin D3 levels result in strong bones and teeth, because it helps regulate and control the body’s ability to absorb phosphorus and calcium.

·     Phosphorus and calcium provide density and strength to both the skeletal system and teeth.

·     Vitamin D deficiency can lead to a loss of bone density, which can contribute to osteoporosis and fractures (broken bones).

·     Severe vitamin D deficiency can also lead to other diseases. In children, it can cause rickets.

Rickets is a rare disease that causes the bones to become soft and bend.

Autoimmune system:

Vitamin D modulates our innate and our adaptive immune responses.

·     Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection.

·     One study showed evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

·     The link between Vitamin D deficiency and autoimmune disease is well documented, which means if you are deficient in Vitamin D you are more likely to contract an autoimmune disease

Cancer Prevention

·     Some evidence supports the idea that increased vitamin D3 can help slow the progression of prostate tumors, while other reports show promise that combining the nutrient with more fiber can reduce the risk of developing polyps that could lead to colon cancer

·     Another helpful combo is vitamin D and calcium: A four-year trial found that when post-menopausal women supplemented with both, their likelihood of developing cancer dropped by 60%

·     Vitamin D has also been frequently studied for its apparent relationship to breast cancer: In a study of 166 women undergoing treatment, nearly 70 percent had low levels of vitamin D, which led many scientists to theorize that there could be a link.

Weight loss

Consider adding vitamin D supplements to your diet if you’re trying to lose weight.

·     In one study, people taking a daily calcium and vitamin D supplement were able to lose more weight than subjects taking a placebo supplement. The scientists said the extra calcium and vitamin D had an appetite-suppressing effect.

How much do you need?

There has been some controversy over the amount of vitamin D needed for healthy functioning. Recent research indicates that you need more vitamin D than was once thought.

·     Normal blood serum levels range from 20, but some organisations say 50, to 100 micrograms per deciliter. But, depending on your blood level, you may need more vitamin D.

The Institute of Food and Agricultural Sciences recommended daily IU intake for vitamin D are:

·     children and teens: 600 IU

·     adults up to age 70: 600 IU

·     adults over age 70: 800 IU

·     pregnant or breastfeeding women: 600 IU

Personally I had a blood test to see what my levels were and then started to supplement with Vitamin D3 and K2. I take 5,000 IU of Vitamin D3 a day.

I recommend that before you start to supplement you have a blood test and then consult a doctor to see what level of supplementation would be favorable.

You may not need to take a supplement if your levels are high enough.

Low Magnesium

A review published in The Journal of the American Osteopathic Association found Vitamin D can't be metabolized without sufficient magnesium levels, meaning Vitamin D remains stored and inactive for as many as 50 percent of Americans.

·     Patients with optimum magnesium levels require less Vitamin D supplementation to achieve sufficient Vitamin D levels.

·     Deficiency in either of these nutrients is reported to be associated with various disorders, including skeletal deformities, cardiovascular diseases and metabolic syndrome

·     Research shows that magnesium consumption from natural foods has decreased in the past few decades, owing to industrialized agriculture and changes in dietary habits

·     The Magnesium status is low in populations who consume processed foods that are high in refined grains, bad fats, phosphate and sugar

DISCLAIMER: The Video Content has been made available for informational and educational purposes only. The video creator does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of the Video Content. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The video creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Video Content, which is provided as is, and without warranties.

FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

#VitaminD #livelonger #DavidSinclair #VitaminK2 #VitaminK

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC

DISCLAIMER: The Video Content has been made available for informational and educational purposes only. The video creator does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of the Video Content. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The video creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Video Content, which is provided as is, and without warranties.

https://pubmed.ncbi.nlm.nih.gov/17158229/

https://pubmed.ncbi.nlm.nih.gov/3530901/

https://pubmed.ncbi.nlm.nih.gov/22516724/

https://pubmed.ncbi.nlm.nih.gov/14654717/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494092/

https://pubmed.ncbi.nlm.nih.gov/23529983/

https://pubmed.ncbi.nlm.nih.gov/18367736/

https://pubmed.ncbi.nlm.nih.gov/14976978/

https://pubmed.ncbi.nlm.nih.gov/22516724/

https://pubmed.ncbi.nlm.nih.gov/15514282/

https://pubmed.ncbi.nlm.nih.gov/15514282/

https://pubmed.ncbi.nlm.nih.gov/19179058/

https://pubmed.ncbi.nlm.nih.gov/22516726/

https://pubmed.ncbi.nlm.nih.gov/23410565/

https://pubmed.ncbi.nlm.nih.gov/16801507/

https://pubmed.ncbi.nlm.nih.gov/18830045/

https://pubmed.ncbi.nlm.nih.gov/9076586/

https://pubmed.ncbi.nlm.nih.gov/16295569/

https://pubmed.ncbi.nlm.nih.gov/17055908/

https://pubmed.ncbi.nlm.nih.gov/8466530/

https://pubmed.ncbi.nlm.nih.gov/16400650/

https://pubmed.ncbi.nlm.nih.gov/23225445/

https://pubmed.ncbi.nlm.nih.gov/18400723/

https://pubmed.ncbi.nlm.nih.gov/1492156/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321250/

https://pubmed.ncbi.nlm.nih.gov/21155624/

https://link.springer.com/article/10.1007/s00198-013-2325-6

https://link.springer.com/chapter/10.1007/978-1-4899-1789-8_19

https://www.healthline.com/nutrition/vitamin-k2

Silver Bullet

As you may know I started NMN experiment to see how NMN worked, but within weeks of getting into it I realized that taking NMN as a daily supplement was not going to be a silver bullet, there are many other things that are key to extending our Health-span

So, as well as NMN supplementation I will also continue to make videos, like this, on other subjects that track my other longevity ‘hacks’ if you like,

Most people have never heard of vitamin K2.

Vitamin K2 is rare in the Western diet and hasn't received much mainstream attention; however this powerful nutrient plays an essential role in many aspects of our health.

What Is Vitamin K?

Vitamin K was discovered in 1929 as an essential nutrient for blood clotting.

·     The initial discovery was reported in a German scientific journal, where it was called “Koagulations-vitamin” — which is where the "K" comes from

·     It was also discovered by the dentist Weston Price, who travelled the world in the early 20th Century studying the relationship between diet and disease in different populations

·     He found that the non-industrial diets were high in some hitherto un-identified nutrient, which seemed to provide protection against tooth decay and chronic diseases

Vitamin K1 & K2

There are two main forms of vitamin K:

·      Vitamin K1, which is found in plant foods like leafy greens

·      Vitamin K2, which is found in some animal and fermented foods

Vitamin K2 can be further divided into several different subtypes, the most important ones being MK-4 and MK-7

How Do Vitamins K1 and K2 Work?

Vitamin K activates proteins that play an important role in blood clotting, calcium metabolism and our heart health

·     One of its most important functions is to regulate calcium deposition. In other words, it promotes the calcification of bones and prevents the calcification of our soft tissues such as blood vessels and kidneys

·     Some scientists have suggested that the roles of vitamins K1 and K2 are very different, and many feel that they should be classified as two separate nutrients, this idea is supported by an animal study showing that vitamin K2 (MK-4) reduced blood vessel calcification whereas vitamin K1 did not.

·     Controlled studies in people also observe that vitamin K2 supplements generally improve bone and heart health, while vitamin K1 shows no significant benefits

However, more human studies are needed before the functional differences between vitamins K1 and K2 can be fully understood

 Heart Disease

·     In one study spanning 10 years, people with the highest intake of vitamin K2 were 52% less likely to develop artery calcification and had a 57% lower risk of dying from heart disease

·     Another study in 16,057 women found that participants with the highest intake of vitamin K2 had a much lower risk of heart disease - for every 10 micrograms of K2 they consumed per day, the risk of heart disease was reduced by 9%

It is generally agreed that more long-term controlled trials on vitamin K2 and heart disease are needed.

Bone Health

Vitamin K2 may Help Improve Bone Health and Lower Your Risk of Osteoporosis

·     Osteoporosis, which translates as “porous bones”, is a common problem in many Western countries. It is prevalent among older women and strongly raises the risk of fractures.

As I mentioned before vitamin K2 plays a central role in the metabolism of calcium; calcium being the most abundant mineral found in our bones and teeth

·     Vitamin K2 activates the calcium-binding actions of two proteins; the matrix GLA protein and osteocalcin, which help to build and maintain bone cells

·     A 3-year study in 244 post-menopausal women found that those taking vitamin K2 supplements had a much slower decrease in age-related bone mineral density

Japanese studies

·     Long-term studies in Japanese women have observed similar benefits, although very high doses were used in these cases. Out of 13 studies, only one failed to show significant improvement.

·     Seven of these trials, which took fractures into consideration, found that vitamin K2 reduced spinal fractures by 60%, hip fractures by 77% and all non-spinal fractures by 81%

·     In line with these findings, vitamin K supplements are officially recommended for preventing and treating osteoporosis in Japan

Dental health

Researchers have speculated that vitamin K2 may also affect dental health; however no human studies to date have tested this directly.

·     Based on animal studies and the role vitamin K2 plays in bone metabolism, it’s reasonable to assume that this nutrient impacts dental health as well

·     One of the main regulating proteins in dental health is osteocalcin, this is the same protein that is critical to bone metabolism and is activated by vitamin K2

·     Osteocalcin triggers a mechanism that stimulates the growth of new dentin, which is the calcified tissue underneath the enamel of your teeth

Cancer

Unfortunately, as we all know cancer is a common cause of death worldwide.

·     Even though modern medicine has found many ways to treat it, new cancer cases are still on the rise. Therefore, finding effective prevention strategies is vital

·     Two clinical studies suggest that vitamin K2 reduces recurrence of liver cancer and increases survival times

·     Additionally, an observational study in 11,000 men found that a high vitamin K2 intake was linked to a 63% lower risk of advanced prostate cancer, whereas vitamin K1 had no effect

That said, it is widely acknowledged that more high-quality studies are needed before any definitive claims can be made.

How to get it

Several widely available foods are rich sources of vitamin K1, but vitamin K2 is less common.

·     Your body can partly convert vitamin K1 into K2. This is useful, as the amount of vitamin K1 in a typical diet is ten times that of vitamin K2.

However, current evidence indicates that the conversion process is inefficient. And as a result, you may benefit much more from supplementing with vitamin K2

·     Vitamin K2 is also produced by gut bacteria in your large intestine. Some evidence suggests that broad-spectrum antibiotics can contribute to K2 deficiency

·     Vitamin K2 is mainly found in fermented foods, which unfortunately most people don't eat

·     Rich animal sources include high-fat dairy products from grass-fed cows, egg yolks, as well as liver and other organ meats, which again most people don't eat

·     The benefits of supplementing with K2 may be enhanced even further when combined with a vitamin D3 supplement, as these two vitamins have strong synergistic effects

FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

#VitaminK #VitaminK2

#RenueByScience #DoNotAge #ProHealthLongevity #YouthandEarth #ProHealth #Youth&Earth

#livelonger #livelong #Aging #Lifespan #healthspan #weightloss #nutrition #fat #drdavidsinclair #immortal #aging #antiaging #NAD #wellness #healthylifestyle #healthyliving #healthy #antiaging #biohacking #healthylife #intermittentfasting #paleo #healing #selfcare #mindset #organic #wellbeing #epigenetics #guthealth #holistic #detox #functionalmedicine #healthyfood #weightloss #plantbased #HealthyHabits

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

 Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

 Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support.

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

Links:

https://clinicaltrials.gov/ct2/show/NCT03675724

https://clinicaltrials.gov/ct2/show/NCT03430037

https://clinicaltrials.gov/ct2/show/NCT03325322

https://pubmed.ncbi.nlm.nih.gov/23517912/

https://pubmed.ncbi.nlm.nih.gov/21738623/

https://pubmed.ncbi.nlm.nih.gov/26741654/

https://pubmed.ncbi.nlm.nih.gov/26759702/

https://selfhacked.com/blog/15-science-based-health-benefits-fisetin-1-favorite/

https://www.lifespan.io/news/fisetin-in-human-clinical-trials/

What is Fisetin?

·     Fisetin is a flavonol, a yellow plant pigment that belongs to the flavonoid group of polyphenols. It gives color to many different fruits and vegetables.

·     Scientists are currently exploring its ability to slow the aging process and extend lifespan, so basically its senolytic effects, which means can Fisetin selectively induce the death of senescent cells and improve health in humans

What’s more, fisetin has powerful anti-inflammatory, antioxidant, and immune-supporting properties

Despite promising animal and cell-based findings, research is still in its early stages. Only three clinical trials to date with humans

Food Sources

Many different fruits and vegetables contain fisetin.

Food sources with the highest concentration of fisetin include:

·     Strawberries (160)

·     Apples (27)

·     Persimmons (11)

·     Lotus root (6)

·     Onions (5)

·     Grapes (4)

·     Kiwi (2)

(the number in brackets relates to the micrograms value per gram of freeze-dried food)

Blocks the NF-κB Pathway

·     The NF-κB pathway is a switch that tells genes to produce inflammatory compounds

·     An overactive NF-κB response is linked to allergies, autoimmune diseases and some cancers. Plus, fisetin blocks inflammatory enzymes that degrade fatty acids.

·     It also reduces the activity of a group of enzymes that cancers require to spread and invade other tissues

 Blocks the mTOR pathway

·     mTOR’s demands for energy and growth can throw your cells into a frenzy: metabolic waste builds up – and there’s no time to clean it up.

·     An overactive mTOR response is associated with cancer, diabetes, obesity, and neurodegenerative diseases. By blocking this pathway, fisetin helps remove waste and enhance cellular metabolism

·     And here’s the most intriguing part: blocking mTOR increases longevity. In fact, blocking mTOR is the only intervention that increased lifespan in all organisms studied to-date, this is because once mTOR is blocked, autophagy is activated: a process of recycling damaged cellular components

Please bear in mind that the vast majority of fisetin health effects haven’t yet been confirmed in clinical trials.

Anti-Ageing

 The following only relate to animal and cell-based studies; they should help with future studies, but have not been proven in humans yet.

·     Aging is characterized by the buildup of senescent cells – cells that stop dividing, become damaged, and start releasing inflammatory molecules

·     As we accumulate more and more of these senescent cells, the body starts being affected. These cells start damaging healthy tissue. They contribute to many age-related diseases – from osteoporosis and cancer to heart and brain diseases, Removing senescent cells calms inflammation, improves physical function, and increases lifespan in animals

·     Certain plant compounds are able to destroy senescent cells without harming healthy cells. In a 2018 cell-based study of 10 such compounds, fisetin was the most effective one. In old mice, fisetin cleared senescent cells and increased their lifespan by over 10%

·     Fisetin also extended the lifespan of fruit flies by more than 20% and yeast by more than 50%, as a result of this a clinical trial is underway to see if fisetin is effective for reducing inflammation and improving frailty and bone health in elderly people

 Diabetes and Its Complications

In multiple animal studies, fisetin restored blood sugar levels of diabetic rats and mice to those of healthy animals. It improved their ability to control blood sugar levels by:

• Increasing insulin levels
• Increasing enzymes that turn sugar into energy
• Removing sugar from the blood to store as glycogen in the liver
• Reducing the liver’s ability to make sugar from lactate and amino acids

·     Fisetin slowed the progression of cataracts and protected the kidneys of diabetic mice by blocking inflammation and oxidative stress. It also protected the liver of diabetic rats from high blood sugar levels by increasing antioxidant levels

·     Another complication of diabetes is the hardening of the arteries and heart disease. In a cell study, fisetin prevented high sugar levels from causing inflammation in blood vessels

 Anticancer Potential

The findings discussed below stem from preliminary clinical research and animal studies. Fisetin isn’t approved for cancer prevention or treatment.

·     Inflammation is linked to colon cancer growth, as well as it’s spread and resistance to chemotherapy. In a clinical study of 37 colon cancer patients undergoing chemotherapy, fisetin (100 mg/day for seven weeks) reduced markers of inflammation.

·     In rats, fisetin reduced oxidative stress and the growth of liver cancer caused by fungal toxins

·     In mice, it prevented the growth of lung cancer and boosted low antioxidant levels caused by a toxin in tobacco smoke. It reduced lung tumor growth by 67% in mice and by 92% when combined with a chemotherapy drug. It also prevented the growth of new blood vessels supplying nutrients to the cancer

·     Another study found that fisetin reduced tumor growth by 66% in mice with melanoma

·     Certain types of prostate cancers are fueled by androgens such as testosterone, fisetin slowed the growth of prostate tumors in mice by blocking the receptors for testosterone on cancer cells

·     Fisetin also protected against kidney damage from chemotherapy in rats by reducing inflammation and boosting antioxidant levels

Cognition

·     Older rats given fisetin experienced memory and learning improvements.

·     Cell studies revealed that fisetin activates pathways in the brain involved in storing memories

In another study, fisetin prevented memory loss in mice exposed to toxins

·    Fisetin can easily cross the blood-brain barrier in mice. This is important as there is an ongoing debate about whether compounds like fisetin can reach high enough levels in the brain to improve its function

Neurodegenerative Diseases

When over activated Immune cells in the brain cause Neurodegenerative diseases such as Alzheimer’s and Huntington’s.

·     This causes inflammation and damage to healthy brain cells. In cells studies, fisetin boosted brain antioxidant levels and prevented these immune cells from releasing inflammatory compounds in response to bacterial toxins

·     Alzheimer’s disease involves the buildup of amyloid plaques and tau proteins in the brain. Fisetin reduced levels of tau proteins in brain cells by activating a process that removes these harmful proteins known as autophagy

·     In mice with amyloid plaques, fisetin improved memory, reduced inflammation, and prevented the loss of brain cell function. In mice with Alzheimer’s, it reduced amyloid plaque buildup and loss of brain cells.

·     Huntington’s disease is a genetic movement disorder in which brain cells get destroyed. In mice with Huntington’s, fisetin was able to improve declining physical function and increase lifespan

Cholesterol

Fisetin reduced high total and LDL cholesterol and triglycerides in rats fed a high-fat diet.

·     In diabetic rats, it doubled HDL levels and cut LDL cholesterol levels in half. A cell study hinted that fisetin reduces cholesterol by causing more of it to be released in the bile

·     Cell studies show that fisetin prevents immune cells called macrophages from oxidizing and ingesting LDL cholesterol. When macrophages ingest oxidized LDL, they create fatty plaques that harden the arteries and cause heart disease

Bone Loss

·     Estrogens keep bones healthy. After menopause, low estrogen levels put women at risk of osteoporosis. The rise inflammation due to aging also weakens the bones

·     Fisetin improved bone density and prevented bone loss in mice with low estrogen levels and inflammation. In cells, it worked by reducing the activity of bone-degrading cells (osteoclasts)



FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

Lonely Soul by Rexlambo https://soundcloud.com/rexlambo

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/-lonely-soul

Music promoted by Audio Library https://youtu.be/_ozYQF0iA6k

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support.

My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

Links:

Dr. Vera: https://www.youtube.com/watch?v=K-QGIyfn6SI&t=112s

Dr. Vera: https://www.youtube.com/watch?v=SGzenQjZ_pU&t=20s

https://pubmed.ncbi.nlm.nih.gov/17091377/

https://pubmed.ncbi.nlm.nih.gov/26978861/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/

https://pubmed.ncbi.nlm.nih.gov/19808648/

https://pubmed.ncbi.nlm.nih.gov/25014997/

https://pubmed.ncbi.nlm.nih.gov/18959406/

https://pubmed.ncbi.nlm.nih.gov/18391466/

https://pubmed.ncbi.nlm.nih.gov/22956862/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970829/

https://pubmed.ncbi.nlm.nih.gov/22052267/

https://pubmed.ncbi.nlm.nih.gov/21896129/

https://www.healthline.com/nutrition/hyaluronic-acid-benefits

https://www.harpersbazaar.com/beauty/skin-care/a25573129/hyaluronic-acid-for-skin-benefits-uses/

https://www.webmd.com/vitamins/ai/ingredientmono-1062/hyaluronic-acid

 So Gentlemen, it’s unlikely you will have heard of this supplement, although the ladies in your life most probably will have and are probably using it too.

So, in the beauty industry Hyaluronic Acid or (HA) is used in a bid to maintain moisture levels in the skin; which I turn leads to smooth, flawless, hydrated and younger looking skin, well that’s the claim.

I won’t get into the hugely inflated cost of HA products and the minuscule amount of HA that each product contains and that it doesn’t stay on your skin long enough to make a difference, maybe I’ll leave that for a future video?

What is Hyaluronic Acid?

·     Hyaluronic acid, also known as hyaluronan, is a clear, gooey substance that is naturally produced by your body

·     The largest amounts of it can be found in your skin, connective tissue (such as bone, cartilage, fat etc.) and in your eyes

·     To keep the molecules in your skin, connective tissue and eyes well lubricated and moist its main function is to retain water,

·     In fact 1 gram of hyaluronic acid can retain up to 2 gallons (7.5 litres) of water, so it is a very powerful humectant

Applications

Hyaluronic acid or HA has a variety of uses, all of which we will cover shortly and it can be administered in a number of ways:

·    As a topical serums and in eye drops

·    As an injection

·    And a supplement

Dr. Vera, First I want to talk quickly about Dr. Vera Gorbunova and her work in the antiaging field

·     She is a Professor of Biology at the University of Rochester, she is also the co-director of the Rochester Aging Research Center and she also sits on the DoNotAge.org advisory board.

Her research is focused on understanding the mechanisms of longevity and genome stability, and on the studies of exceptionally long-lived mammals

·     She has spoken at TEDx in Cannes and at the Undoing Aging conference in Berlin; links in the description below to these talks, both extremely interesting and well worth a watch

·     The naked mole rat lives on average for 30 years; the longest lived rodent by far. The average mouse lives for only 4 years.

Dr Vera Gorbunova concludes that this may be because of their abundance of High Molecular Weight Hyaluronic Acid or HMW-HA

·     Naked mole rats very, very rarely get cancer and Vera and her team found that removing the HMW-HA from her naked mole rats makes them more prone to cancer

So, it appears that the more HMW-HA, the less likely your cancer risk.

Please note this study was done in rodents and that human trials are not yet concluded

Hyaluronic Acid Promotes Healthier and More Supple Skin

·     Hyaluronic acid supplements can help your skin look and feel suppler. Roughly half of the hyaluronic acid in your body is present in your skin, where it binds to water to help retain moisture.

·     However, the natural aging process and exposure to things such as ultraviolet radiation from the sun, tobacco smoke and pollution can decrease the amount in your skin. Taking hyaluronic acid supplements may prevent this decline by raising the depleted levels

·     Doses of 120–240 mg per day for at least one month have been shown to significantly increase skin moisture and reduce dry skin in adults

·     Hydrated skin also reduces the appearance of wrinkles, which may explain why several studies show that supplementing with it can make skin appear smoother

 Study in Japan:

·     Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet were randomly assigned 120 mg/day or a placebo

·     The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks. The skin wrinkles were evaluated by image analysis of skin wrinkle replicas, and their skin condition was evaluated using a questionnaire

·     Results: During the study period, the HA groups showed better level of the whole sulcus volume ratio, wrinkle area ratio, and wrinkle volume ratio than the placebo group

After 8 weeks of ingestion, the HA group showed significantly diminished wrinkles compared with the placebo group.

After 12 weeks skin luster and suppleness significantly improved compared with their baseline

·     Conclusion: The results suggest that the HA supplementation inhibits skin wrinkles and improves skin condition

 Hyaluronic acid Can Speed Wound Healing

Hyaluronic acid also plays a key role in wound healing.

·     It’s naturally present in the skin, but its concentrations increase when there is damage in need of repair

·     Hyaluronic acid helps wounds heal faster by regulating inflammation levels and signaling the body to build more blood vessels in the damaged area). Applying it to skin wounds has been shown to reduce the size of wounds and decrease pain faster than a placebo or no treatment at all

·     Hyaluronic acid also has antibacterial properties, so it can help reduce the risk of infection when applied directly to open wounds

·     What’s more, it’s also effective at combating gum disease, speeding up healing after tooth surgery and eliminating ulcers when used topically in the mouth

 Hyaluronic Acid can Relieve Joint Pain

·     Hyaluronic acid is also found in our joints; here it keeps the space between your bones well lubricated, when the joints are lubricated the bones are less likely to grind against each other and cause discomfort and pain

·     Hyaluronic acid supplements are very helpful for people suffering from osteoarthritis, a type of degenerative joint disease caused by wear and tear on the joints over time

·     Taking 80–200 mg daily for at least two months has been shown to significantly reduce knee pain in people with osteoarthritis, especially those between the ages of 40 and 70

Hyaluronic Acid may Soothe Acid Reflux Symptoms

·     New research shows hyaluronic acid supplements may help reduce the symptoms of acid reflux.

When acid reflux occurs, the contents of the stomach are regurgitated up into the throat, causing pain and damage to the lining of the esophagus. Hyaluronic acid may help soothe the damaged lining of the esophagus and speed up the recovery process.

·     One human study found that taking a hyaluronic acid and a kondrowatin sulfate supplement along with an acid-reducing medication decreased reflux symptoms 60% more than taking an acid-reducing medication alone.

A second study showed that the same type of supplement was five times more effective at reducing acid reflux symptoms than a placebo

Research in this area is still relatively new, and more studies are needed to replicate these results. Nevertheless, these outcomes are certainly promising

Hyaluronic Acid Relieves Dry Eye and Discomfort

·     Approximately 1 out of 7 older adults suffer from the symptoms of dry eye because of reduced tear production or tears evaporating too quickly; hyaluronic acid is excellent at retaining moisture, it’s often used to treat dry eye

·     Eye drops containing 0.2 to 0.4% hyaluronic acid have been shown to reduce dry eye symptoms and improve overall eye health

·     Contact lenses that contain slow-release hyaluronic acid are also being developed as a possible treatment for dry eye.

In addition, hyaluronic acid eye drops are frequently used during eye surgery to reduce inflammation and speed wound healing

To date, no studies have examined the effects of hyaluronic acid supplements on dry eye, but it may be a future area of research

Preserve Bone Strength

New animal research has begun to investigate the effects of hyaluronic acid supplements on bone health.

·     Two studies have found that hyaluronic acid supplements can help slow the rate of bone loss in rats with osteopenia, the initial stage of bone loss that precedes osteoporosis

·     Test-tube studies have also shown that high doses of hyaluronic acid can increase the activity of osteoblasts, the cells that are responsible for building new bone tissue

While its effects on human bone health have not yet been studied, early animal and test-tube studies are extremely promising

Could Prevent Bladder Pain

·     Approximately 3 to 6% of women suffer from a condition called inter-stish-al cy-sti-tis, or painful bladder syndrome, this disorder causes abdominal pain and tenderness, along with a strong and frequent urge to urinate

·     While the causes of this condition are unknown, hyaluronic acid has been found to help relieve the pain and urinary frequency associated with this condition when inserted directly into the bladder through a catheter

·     It's unclear why hyaluronic acid helps relieve these symptoms, but researchers hypothesize that it helps repair damage to bladder tissue, making it less sensitive to pain

Studies have not yet determined whether oral hyaluronic acid supplements can increase amounts of it in the bladder enough to have the same effects

Possible Side Effects and Precautions

Hyaluronic acid is generally very safe to use, with very few reported side effects

·     Since the body naturally produces it, allergic reactions are very rare, one study in 60 people with osteoarthritis who took 200 mg daily for one year reported no negative side effects

·     However, its effects during pregnancy or breastfeeding have not been thoroughly studied, so these groups should be cautious and avoid supplementing with it

·     There is also some evidence that cancer cells are sensitive to hyaluronic acid and taking supplements could make them grow faster, for this reason, it is generally advised that people with cancer or who have a family a history of cancer avoid supplementing with it

·     Hyaluronic acid injections into the skin or joints have a higher risk of side effects. However, negative reactions are mostly associated with the injection procedure, rather than hyaluronic acid itself

FAIR-USE COPYRIGHT DISCLAIMER

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

Signal to Noise by Scott Buckley https://soundcloud.com/scottbuckley

Creative Commons - Attribution 3.0 Unported - CC BY 3.0

Free Download/Stream: https://bit.ly/signal-to-noise

Music promoted by Audio Library https://youtu.be/of0Ei_T4isc

I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:

  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment

  * Patreon: https://bit.ly/3hhfjl5

  * SubscribeStar: https://bit.ly/3psYo23

Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)

ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/)

DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)

Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN)

Renue by Science 15% Subscription Service Discount Code: MYNMNSUB

Things I would and would not have changed:

·    See a doctor or health practitioner, I know that this will not be easy, a lots don’t know about LCHF let alone NMN, and still say things like LDL is your bad cholesterol, with no idea what VLDL is at all, so seek out one that is open to what you are doing

·    Would have gone from 0 to 1 gram quicker? Yes, but I only know this now because I did it slowly, there is no official dosage protocol, so we are all still guessing; Hindsight is a great thing and it may be different for you, so start small and work up at a pace you and more importantly your body are happy with

·    Blood tests as a baseline, get as many markers checked as you can afford (you know, this is not a bad thing to do anyway), I waited until I was increasing my dose to 1 gram a day; if I were starting again I would do it before day 1

·    Have a reliable way to check your biometric markers, if you can, buy a quality scale, my first gym almost doubling their prices overnight and the virus shutting down my second gym certainly wasn’t something I, or anyone, could have envisaged at the start of the experiment

·    If you can afford it, have a DEXA scan, possibly the most effective way to measure your bio-metric markers, although be aware you will be exposed to very minor levels of radiation during the procedure

·    Find out your biological age, use an Epi-genetic/DNA marker test, blood or saliva. Biometric scales use BMI as part of the formula to estimate the biological age, as you may know I do not hold any store in that antiquated formula

·    I would have taken TMG with NMN from the start, although not proven, methylation or depleting our methyl groups is something that we need to avoid

·    DNA now sell TMG, £15 (around $19) for 30 grams, again use my discount code ‘MYNMN’ to get 10% off

·    I would have added equal amounts of Resveratrol as I upped my dose of NMN, maybe 1 month after I was happy with no NMN side effects, something like this:

22 April: 125 mg NMN*

22 May: add 125mg of Resveratrol

22 June: up to 250mg NMN*

22 July: up to 250mg of Resveratrol, and so on.

So, essentially stagger, the increase in dosage to see if there were any side effects.

The asterisk denotes that the NMN would be taken with at least the same dose of TMG

•     A little more research may have made the journey a little less fraught; but then you don’t know what you don’t know

•     TMG, it wasn’t until I had been taking NMN for a few months that people, far more in the know than I, alerted me to methylation and the need to take TMG

•     Resveratrol v Trans-resveratrol, again it wasn’t until someone mentioned it in the comments section and then David Sinclair confirmed (during an interview) that it must be Trans and not cis-resveratrol. I took cis-resveratrol for a few months before I knew this (this will have affected my results, to what extent I will never know)

•     Berberine dose, Purely by luck I started to take one gram of Berberine in lieu of 1 gram of Metformin (as David Sinclair does), before I found out, again from a subscriber that 1 gram of Berberine is roughly equal to 1 gram of Metformin; Info from a Valter Longo video.

•     Supplier, To date I have now NMN from 4 different suppliers, the latest be DoNotAge.org – I think that some diligent research on what suppliers to choose, so you don’t run out, maybe have 2 that you trust, that:

•     Do show 3rd party test certificates (not will send on request)

•     And can ship to your country (this was a big one for me)

·    Think about recording, as I did, things that you think may be affected by NMN, actually record them - i.e. sleep, exercise, hunger size etc. Also record things such as headaches, upset stomach etc. also record if they didn’t happen; remember no data is data

·    Don't start this with another big change; you may use taking NMN as part of a big life change i.e.

o Take NMN and go carnivore or Vegan

o Take NMN and starting to exercise regularly

o Take NMN and giving up sugar

·    I am glad I was happy with my diet and exercise regime; big changes may have altered my Stat’s i.e. doing extra exercise, changing fasting regime etc. would have shown non-NMN triggered changes

·    Be aware of potential side effects, sleep issues, upset stomach, extra energy (don’t take at night) etc. Be aware that these things may happen

Pharma grade or Food Grade

·     No Grades, there is no food grade, pharmaceutical grade of veterinary grade, there is just NMN, these grade labels are all unofficial and do not meet any official standard

·     CAS Registry Number, NMN has a CAS number, go to this website and enter in this number and it will show you all the information about NMN. I was told by a reliable source that, if there were more than 1 type of NMN, it would have a separate number.

·     Purity, the % of purity is the percentage of the desired material which is actually in the sample. It is not a standard, there is no standard that allows a company to call it’s NMN Pure, ultra pure, mega pure etc. these are labels made up by supplement companies, mainly to entice you, also to mislead (but within the law).

The decision is up to you, are you happy with 95% purity or must you have 99%+ - Pharma grade, food grade, pure, super pure, ultra-pure are just labels, ignore them, just look at the percentage number, what is the difference between 99.5% and 95.5%, will the extra 4% actually make a difference at the molecular level, who knows? I’m sure the NMN companies, if asked, will certainly tell you ‘there is strong evidence to say it could or it may, it would be safer to take as pure a product as is possible; they don’t know, they don’t care, they just want your orders, they just want your money. Be sure you know what you are paying for, the purity level and not the unofficial label.

·     Cost, so basically, it is all down to cost, what can you afford? What purity do you think will have an effect?

Signal To Noise by Scott Buckley https://soundcloud.com/scottbuckley

Creative Commons — Attribution 3.0 Unported — CC BY 3.0

Free Download / Stream: https://bit.ly/signal-to-noise

Music promoted by Audio Library https://youtu.be/of0Ei_T4isc